Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis

BİÇER GÖMCELİ, Yasemin; Yüksel, Burcu; Yaman, Aylin; KUTLU, GÜLNİHAL; genç, fatma

Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis

Fatma GENÇ, (University of Health Sciences Antalya Training and Research Hospital, Department of Neurology,Antalya, Turkey)

Aylin YAMAN, (University of Health Sciences Antalya Training and Research Hospital, Department of Neurology,Antalya, Turkey)

Burcu YÜKSEL, (University of Health Sciences Antalya Training and Research Hospital, Department of Neurology,Antalya, Turkey)

Yasemin BİÇER GÖMCELİ, (University of Health Sciences Antalya Training and Research Hospital, Department of Neurology,Antalya, Turkey)

Gülnihal KUTLU (Muğla Sıtkı Koçman University Faculty of Medicine, Department of Neurology and Clinical Neurophysiology, Muğla, Turkey)

Journal of Neurological Sciences (Turkish)

3 1

Yıl: 2017 Cilt: 34 Sayı: 2 Sayfa Aralığı: 136 - 142 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis

Öz:

Amaç: Myastenia Gravis (MG) otoimmün bir hastalıktır. Solunum güçsüzlüğü ve bulber güçsüzlük potansiyel olarak geri dönüşümlü en önemli komplikasyonlar olup erken tespit edilmesi tedavide yol göstericidir. Bu çalışmada MG hastalarında gelişebilecek respiratuar yetmezliğin tespitinde uzun torasik sinir repetetif stimulasyonunun (RNS) solunum fonksiyon testi ile korelasyonu ve güvenilirliğini araştırmayı amaçladık. Metod: Yirmibir MG hastası ve 21 sağlıklı kontrol grubu çalışmaya dahil edildi. Fasiyal, ulnar, uzun torasik sinirlerde repetetif sinir uyarımı (3 Hz) yapıldı. Birinci ve dördüncü birleşik kas aksiyon potansiyel (BKAP) amplitüdleri arasındaki fark kaydedildi. Solunum fonksiyonları, zorlu vital kapasite (FVC) ve birinci saniyedeki zorlu ekspirasyon hacminin (FEV1), FVC'ye oranı ölçülerek değerlendirildi. Bulgular: Hasta grubunda 15 erkek ve 6 kadın vardı. Uzun torasik sinirin fasiyal sinire göre duyarlılık ve özgüllüğü, 0.86 ve 0.66 idi. Hasta ve kontrol grubu arasında serratus anterior kasından (SA) kaydedilen dekrement yanıtlar arasında anlamlı fark saptandı. SA kasından kaydedilen dekrement yanıtların yüzdesi ile FEV1/FVC oranı arasında güçlü bir korelasyon gözlendi. Sonuç: Uzun torasik sinirin repetetif uyarımı; solunum fonksiyon testi ile kıyaslandığında iyi tolere edilebilen ve MG'e bağlı solunum disfonksiyonunun erken teşhisinde basit bir yöntemdir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Myastenia Graviste Repetetif Uzun Torasik Sinir Uyarımının Klinik ve Solunum Fonksiyon Testleri ile Korelasyonu

Öz:

Objective: Myasthenia gravis (MG) is an autoimmune disease. Respiratory weakness and bulbar involvement are the major complications and early diagnosis of these complications is very important for the planning of treatment. Method and Patients: Twenty-one patients with myasthenia gravis and 21 healthy controls were included in this study. Repetitive nerve stimulation (3Hz) tests were performed on facial, ulnar and long thoracic nerves. The difference between the first and fourth compound muscle action potential (CMAP) amplitudes was recorded. Respiratory functions were evaluated using forced vital capacity (FVC) and the ratio of forced expiratory volume in 1s (FEV1) to FVC. Results: 15 male and 6 female patients were included in the patient group. The sensitivity and specificity of long thoracic nerve compared to facial nerve were 0.86 and 0.66, respectively. There was a significant difference between the decrements recorded from serratus anterior (SA). A strong correlation was observed between the percentage of the decrement recorded from SA and FEV1/FVC ratio. Conclusions: The use of repetitive stimulation of long thoracic nerve compared to respiratory function tests might be a well-tolerated and simple way for the early diagnosis of pulmonary dysfunction in MG. Significance: This well-tolerated method should be recommended in routine electromyography protocols.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	genç f, Yaman A, Yüksel B, BİÇER GÖMCELİ Y, KUTLU G (2017). Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. , 136 - 142.
Chicago	genç fatma,Yaman Aylin,Yüksel Burcu,BİÇER GÖMCELİ Yasemin,KUTLU GÜLNİHAL Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. (2017): 136 - 142.
MLA	genç fatma,Yaman Aylin,Yüksel Burcu,BİÇER GÖMCELİ Yasemin,KUTLU GÜLNİHAL Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. , 2017, ss.136 - 142.
AMA	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. . 2017; 136 - 142.
Vancouver	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. . 2017; 136 - 142.
IEEE	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G "Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis." , ss.136 - 142, 2017.
ISNAD	genç, fatma vd. "Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis". (2017), 136-142.

APA	genç f, Yaman A, Yüksel B, BİÇER GÖMCELİ Y, KUTLU G (2017). Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. Journal of Neurological Sciences (Turkish), 34(2), 136 - 142.
Chicago	genç fatma,Yaman Aylin,Yüksel Burcu,BİÇER GÖMCELİ Yasemin,KUTLU GÜLNİHAL Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. Journal of Neurological Sciences (Turkish) 34, no.2 (2017): 136 - 142.
MLA	genç fatma,Yaman Aylin,Yüksel Burcu,BİÇER GÖMCELİ Yasemin,KUTLU GÜLNİHAL Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. Journal of Neurological Sciences (Turkish), vol.34, no.2, 2017, ss.136 - 142.
AMA	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. Journal of Neurological Sciences (Turkish). 2017; 34(2): 136 - 142.
Vancouver	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis. Journal of Neurological Sciences (Turkish). 2017; 34(2): 136 - 142.
IEEE	genç f,Yaman A,Yüksel B,BİÇER GÖMCELİ Y,KUTLU G "Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis." Journal of Neurological Sciences (Turkish), 34, ss.136 - 142, 2017.
ISNAD	genç, fatma vd. "Correlation of Respiratory Function Tests With Repetitive Stimulation of Long Thoracic Nerve in Myasthenia Gravis". Journal of Neurological Sciences (Turkish) 34/2 (2017), 136-142.