Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı

DURSUN, HATİCE GÜL; ÇETİNKAYA, Sümeyra

Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı

Sümeyra ÇETİNKAYA, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Biyoloji AD, Konya, Türkiye)

Hatice Gül DURSUN (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Biyoloji AD, Konya, Türkiye)

Sakarya Tıp Dergisi

29 5

Yıl: 2016 Cilt: 6 Sayı: 2 Sayfa Aralığı: 56 - 63 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı

Öz:

Endoplazmik Retikulum (ER) 'un fonksiyonları protein ve lipid biyosentezi, protein katlanması ve trafiği, kalsiyum homeostazı ve çeşitli diğer yaşamsal süreçlerdir. ER 'de yanlış katlanmış ya da katlanmamış proteinlerin birikimi ER homeostazında değişikliklere yol açar. ER fonksiyonlarını hasara uğratan hücresel durumlar olduğunda, ER stresi meydana gelir ve sonuç olarak katlanmamış protein yanıtı (UPR) olarak isimlendirilen bir yolak aktive olur. UPR sinyal yolağı ER şaperonlarının miktarını artırır ve protein translasyonunu düzenler. UPR iki zıt fonksiyona sahiptir: ilki ER homeostazını yeniden sağlamak ve ikincisi apoptozisin ya da otofajinin uyarılmasını içeren adaptif mekanizmalar geliştirmek. UPR stres koşullarının üstesinden gelemezse, üçüncü bir yol olarak hücrenin sağkalımı ve büyümesine de izin verebilir. Sonuç olarak, metabolik hastalıklar, nörodejeneratif hastalıklar, inflamatuar hastalıklar ve kanser meydana gelebilir

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Cell Life and Death Decision in Endoplasmic Reticulum Stress

Öz:

Functions of the endoplasmic reticulum (ER) are protein and lipid biosynthesis, protein folding and trafficking, calcium homeostasis, and several other vital processes. Accumulation of misfolded or unfolded proteins in the ER lead to alterations in ER homeostasis. When celular states damage ER functions, ER stress take place and subsequent activates a pathway named as the unfolded protein response (UPR). UPR signalling pathways increase level of ER chaperones, regulate protein translation. UPR has two opposite function: first reestablish ER homeostasis and second improve adaptive mechanisms involving the stimulation apoptosis or autophagy. UPR is not overcome of stress conditions, as the third phenomenon can allow survival and growth of cell. Consequently, various pathological conditions including metabolic diseases, neurodegenerative diseases, inflammatory diseases, and cancer can occur. ( Sakarya Med J 2016, 6(2):73-80 )

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	ÇETİNKAYA S, DURSUN H (2016). Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. , 56 - 63.
Chicago	ÇETİNKAYA Sümeyra,DURSUN HATİCE GÜL Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. (2016): 56 - 63.
MLA	ÇETİNKAYA Sümeyra,DURSUN HATİCE GÜL Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. , 2016, ss.56 - 63.
AMA	ÇETİNKAYA S,DURSUN H Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. . 2016; 56 - 63.
Vancouver	ÇETİNKAYA S,DURSUN H Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. . 2016; 56 - 63.
IEEE	ÇETİNKAYA S,DURSUN H "Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı." , ss.56 - 63, 2016.
ISNAD	ÇETİNKAYA, Sümeyra - DURSUN, HATİCE GÜL. "Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı". (2016), 56-63.

APA	ÇETİNKAYA S, DURSUN H (2016). Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. Sakarya Tıp Dergisi, 6(2), 56 - 63.
Chicago	ÇETİNKAYA Sümeyra,DURSUN HATİCE GÜL Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. Sakarya Tıp Dergisi 6, no.2 (2016): 56 - 63.
MLA	ÇETİNKAYA Sümeyra,DURSUN HATİCE GÜL Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. Sakarya Tıp Dergisi, vol.6, no.2, 2016, ss.56 - 63.
AMA	ÇETİNKAYA S,DURSUN H Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. Sakarya Tıp Dergisi. 2016; 6(2): 56 - 63.
Vancouver	ÇETİNKAYA S,DURSUN H Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı. Sakarya Tıp Dergisi. 2016; 6(2): 56 - 63.
IEEE	ÇETİNKAYA S,DURSUN H "Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı." Sakarya Tıp Dergisi, 6, ss.56 - 63, 2016.
ISNAD	ÇETİNKAYA, Sümeyra - DURSUN, HATİCE GÜL. "Endoplazmik Retikulum Stresinde Hücre Sağkalım ve Ölüm Kararı". Sakarya Tıp Dergisi 6/2 (2016), 56-63.