Yıl: 2017 Cilt: 63 Sayı: 3 Sayfa Aralığı: 249 - 252 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis

Öz:
Objectives: In this study, we aimed to evaluate the relationship of serum magnesium (Mg) with the radiological severity and inflammation in the patients with knee osteoarthritis (OA).Patients and methods: A total of 75 patients (61 females, 14 males; mean age 67.5±9.9 years; range 44 to 92 years) with the Kellgren-Lawrence Grade 1-4 knee OA were included in the study. Serum Mg levels (mg/dL) and inflammatory markers including erythrocyte sedimentation rate (ESR; mm/h) and C-reactive protein (CRP; mg/dL) were recorded. Serum Mg levels of the patients with mild OA and severe OA were compared. The correlation between Mg and both inflammatory markers was analyzed.Results: Severe OA group had significantly lower Mg levels than the mild OA group (p=0.044). Serum Mg level was not found to be correlated with either inflammatory biomarkers.Conclusion: Although serum Mg is associated with the radiological severity of knee OA, it is not associated with inflammatory biomarkers including ESR and CRP
Anahtar Kelime:

Konular: Rehabilitasyon
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, et al. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr 2005;45:145-64.
  • 2. Nielsen FH. Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 2010;68:333-40.
  • 3. Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003;24:39-52.
  • 4. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med 2003;24:107-36.
  • 5. Abbott RD, Ando F, Masaki KH, Tung KH, Rodriguez BL, Petrovitch H, et al. Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol 2003;92:665-9.
  • 6. Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, et al. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 2007;86:743-51.
  • 7. Leone N, Courbon D, Ducimetiere P, Zureik M. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 2006;17:308-14.
  • 8. Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, et al. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One 2015;10: 127666.
  • 9. Zeng C, Wei J, Li H, Yang T, Zhang FJ, Pan D, et al. Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis. J Rheumatol 2015;42:1231-6.
  • 10. Qin B, Shi X, Samai PS, Renner JB, Jordan JM, He K. Association of dietary magnesium intake with radiographic knee osteoarthritis: results from a population-based study. Arthritis Care Res (Hoboken) 2012;64:1306-11.
  • 11. Hunter DJ, Hart D, Snieder H, Bettica P, Swaminathan R, Spector TD. Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins. Rheumatology (Oxford) 2003;42:1311-6.
  • 12. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.
  • 13. Baker JF, Byrne DP, Walsh PM, Mulhall KJ. Human chondrocyte viability after treatment with local anesthetic and/or magnesium: results from an in vitro study. Arthroscopy 2011;27:213-7.
  • 14. Feyerabend F, Witte F, Kammal M, Willumeit R. Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation. Tissue Eng 2006;12:3545-56.
  • 15. Vormann J, Förster C, Zippel U, Lozo E, Günther T, Merker H, et al. Effects of magnesium deficiency on magnesium and calcium content in bone and cartilage in developing rats in correlation to chondrotoxicity. Calcif Tissue Int 1997;61:230-8.
APA BENLİDAYI İ, Gokcen N, SARPEL T (2017). Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. , 249 - 252.
Chicago BENLİDAYI İlke Çoşkun,Gokcen Neslihan,SARPEL TUNAY Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. (2017): 249 - 252.
MLA BENLİDAYI İlke Çoşkun,Gokcen Neslihan,SARPEL TUNAY Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. , 2017, ss.249 - 252.
AMA BENLİDAYI İ,Gokcen N,SARPEL T Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. . 2017; 249 - 252.
Vancouver BENLİDAYI İ,Gokcen N,SARPEL T Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. . 2017; 249 - 252.
IEEE BENLİDAYI İ,Gokcen N,SARPEL T "Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis." , ss.249 - 252, 2017.
ISNAD BENLİDAYI, İlke Çoşkun vd. "Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis". (2017), 249-252.
APA BENLİDAYI İ, Gokcen N, SARPEL T (2017). Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 63(3), 249 - 252.
Chicago BENLİDAYI İlke Çoşkun,Gokcen Neslihan,SARPEL TUNAY Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 63, no.3 (2017): 249 - 252.
MLA BENLİDAYI İlke Çoşkun,Gokcen Neslihan,SARPEL TUNAY Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.63, no.3, 2017, ss.249 - 252.
AMA BENLİDAYI İ,Gokcen N,SARPEL T Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2017; 63(3): 249 - 252.
Vancouver BENLİDAYI İ,Gokcen N,SARPEL T Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2017; 63(3): 249 - 252.
IEEE BENLİDAYI İ,Gokcen N,SARPEL T "Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 63, ss.249 - 252, 2017.
ISNAD BENLİDAYI, İlke Çoşkun vd. "Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 63/3 (2017), 249-252.