Narghile has been used commonly by the elderly in the last 400 years and also by younger populationsince 1980’s. Carbon monoxide poisoning in narghile smokers is very rare. In this presentation, twofemale patients aged 20 and 21 years old and who have exhibited carbon monoxide poisoning afternarghile smoking were evaluated. They were presented to the emergency department due to syncopeand their carboxyhemoglobin levels were measured as 26.5 and 21.4, respectively. Narghile smoking hasbecome very popular especially in the young population in recent years. Carbon monoxide poisoningrates with nonspecific symptoms like lassitude, fatigue and fainting has also increased together with thisincrease. Narghile use/exposure should be questioned carefully especially in young patients admitted tothe emergency department with nonspecific symptoms.