Yıl: 2017 Cilt: 47 Sayı: 4 Sayfa Aralığı: 1078 - 1088 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors

Öz:
Background/aim: The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors. Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used. Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and in the group of patients whose diagnosis was delayed for more than 3 months. Total quality of life scores for children and their parents were 82.95 ± 14.59 vs. 83.61 ± 14.60 before, 54.69 ± 16.51 vs. 55.78 ± 16.05 during, and 83.88 ± 12.44 vs. 84.19 ± 13.22 at the end of treatment (P < 0.05). Anxiety and depression scores were significantly higher during treatment, in patients whose diagnoses were delayed for more than 3 months, and among inpatients. Conclusion: The quality of life of a majority of our patients was severely affected, and depression and anxiety were more frequently seen especially during treatment.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan-Lottick NS. A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group. Cancer 2014; 120: 1417-1425.
  • 2. Landolt MA, Vollrath M, Niggli FK, Gnehm HE, Sennhauser FH. Health-related quality of life in children with newly diagnosed cancer: a one year follow-up study. Health Qual Life Outcomes 2006; 20: 63.
  • 3. Sawyer M,  Antoniou G, Toogood I,  Rice M, Baghurst P. Childhood cancer: a 4-year prospective study of the psychological adjustment of children and parents. J Pediatr Hematol Oncol 2000; 22: 214-220.
  • 4. Huang IC,  Brinkman TM,  Kenzik K, Gurney JG, Ness KK, Lanctot J, Shenkman E, Robison LL, Hudson MM, Krull KR. Association between the prevalence of symptoms and healthrelated quality of life in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort study. J Clin Oncol 2013; 31: 4242-4251.
  • 5. van der Geest IM,  van Dorp W,  Hop WC, Neggers SJ, de Vries AC, Pieters R, Aarsen FK, van den Heuvel-Eibrink MM. Emotional distress in 652 Dutch very long-term survivors of childhood cancer, using the hospital anxiety and depression scale (HADS). J Pediatr Hematol Oncol 2013; 35: 525-529.
  • 6. Yağci-Küpeli B, Akyüz C, Küpeli S, Büyükpamukçu M. Health-related quality of life in pediatric cancer survivors: a multifactorial assessment including parental factors. J Pediatr Hematol Oncol 2012; 34: 194-199.
  • 7. Deyell RJ, Lorenzi M, Ma S, Rassekh SR,  Collet JP,  Spinelli JJ,  McBride ML. Antidepressant use among survivors of childhood, adolescent and young adult cancer: a report of the Childhood, Adolescent and Young Adult Cancer Survivor (CAYACS) Research Program. Pediatr Blood Cancer 2013; 60: 816-822.
  • 8. Gordijn MS,  van Litsenburg RR,  Gemke RJ, Huisman J, Bierings MB, Hoogerbrugge PM, Kaspers GJ. Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2013; 60: 479- 485.
  • 9. Kinahan KE, Sharp LK, Seidel K, Leisenring W,  Didwania A,  Lacouture ME,  Stovall M,  Haryani A,  Robison LL, Krull KR. Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor study. J Clin Oncol 2012; 30: 2466-2474.
  • 10. Jalmsell L, Kreicbergs U, Onelöv E, Steineck G, Henter JI. Symptoms affecting children with malignancies during the last month of life: a nationwide follow up. Pediatrics 2006; 117: 1314-1320.
  • 11. Eyigor S, Karapolat H, Yesil H, Kantar M. The quality of life and psychological status of mothers of hospitalized pediatric oncology patients. Pediatr Hematol Oncol 2011; 28: 428-438.
  • 12. Compas BE,  Desjardins L,  Vannatta K, Young-Saleme T, Rodriguez EM, Dunn M, Bemis H, Snyder S, Gerhardt CA. Children and adolescents coping with cancer: self- and parent reports of coping and anxiety/depression. Health Psychol 2014; 33: 853-861.
  • 13. Seitz DC,  Besier T,  Debatin KM, Grabow D, Dieluweit U, Hinz A, Kaatsch P, Goldbeck L. Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence. Eur J Cancer 2010; 46: 1596-1606.
  • 14. Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care 1999; 37: 126-139.
  • 16. Çakın Memik N, Ağaoğlu B, Coşkun A, Üneri ÖŞ, Karakaya I. The validity and reliability of the Turkish Pediatric Quality of Life Inventory for children 13-18 years old. Turk Psikiyatr Derg 2007; 18: 353-363.
  • 17. Kovacs M. The Children’s Depression Inventory (CDI). Psychopharmacol Bull 1981; 21: 995-998.
  • 18. Öy B. Children’s Depression Inventory: depression scale for children: study of validity and reliability. Turk Psikiyatr Derg 1991; 2: 132-137.
  • 19. Birmaher B, Khetarpal S, Brent D, Cully M,  Balach L,  Kaufman J,  Neer SM. The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry 1997; 36: 545-553.
  • 20. Maurice-Stam H, Grootenhuis MA, Brons PP, Caron HN, Last BF. Psychosocial indicators of health-related quality of life in children with cancer 2 months after end of successful treatment. J Pediatr Hematol Oncol 2007; 29: 540-550.
  • 21. Langeveld NE, Grootenhuis MA, Voûte PA, de Haan RJ, van den Bos C. Quality of life, self-esteem and worries in young adult survivors of childhood cancer. Psychooncology 2004;13: 867-881.
  • 22. Wu E,  Robison LL,  Jenney ME,  Rockwood TH, Feusner J, Friedman D, Kane RL, Bhatia S. Assessment of health related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire. Pediatr Blood Cancer 2007; 48: 678-686.
  • 23. Oeffinger KC, Nathan PC, Kremer LCM. Challenges after curative treatment for childhood cancer and long-term follow up of survivors. Pediatr Clin North Am 2008; 55: 251- 273.
  • 24. Maunsell E,  Pogany L,  Barrera M,  Shaw AK, Speechley KN. Quality of life among long-term adolescent and adult survıvors of childhood cancer. J Clin Oncol 2006; 24: 2527- 2535.
  • 25. Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P. The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module. Cancer 2002; 94: 2090-2106.
  • 26. Alessi D, Dama E, Barr R, Mossoa ML, Maule M,  Magnani C, Pastore G, Merletti F. Health-related quality of life of long term childhood cancer survivors: a population-based study from the childhood cancer registry of piedmont, Italy. Eur J Cancer 2007; 43: 2545-2552.
  • 27. Webster K, Cella D. Quality of life in patients with low-grade non-Hodgkin’s lymphoma. Oncology (Williston Park) 1998; 12: 697-714.
  • 28. Vannatta K,  Gartstein MA,  Short A, Noll RB. A controlled study of peer relationships of children surviving brain tumors: teacher, peer, and self ratings. J Pediatr Psychol 1998; 23: 279- 287.
  • 29. Armstrong GT, Liu Q, Yasui Y, Huang S, Ness KK, Leisenring W,  Hudson MM,  Donaldson SS,  King AA,  Stovall M et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the childhood cancer survivor study. J Natl Cancer Inst 2009; 101: 946-958.
  • 30. Eiser C, Vance H, Horne B, Glaser A, Galvin H. The value of the PedsQLTM in assessing quality of life in survivors of childhood cancer. Child Care Health Dev 2003; 29: 95-102.
  • 31. Meeske KA, Patel SK, Palmer SN, Nelson MB, Parow AM. Factors associated with health-related quality of life in pediatric cancer survivors. Pediatr Blood Cancer 2007; 49: 298-305.
  • 32. Chou LN, Hunter A. Factors affecting quality of life in Taiwanese survivors of childhood cancer. J Adv Nurs 2009; 65: 2131-2141.
  • 33. Magal-Vardi O, Laor N, Toren A, Strauss L, Wolmer L, Bielorai B, Rechavi G, Toren P. Psychiatric morbidity and quality of life in children with malignancies and their parents, J Nerv Ment Dis 2004; 192: 872-875.
  • 34. Yarış N, Yavuz MN, Yavuz AA, Ökten A. Assessment of quality of life in pediatric cancer patients at diagnosis and during therapy. Turkish Journal of Cancer 2001; 31: 139-149.
  • 35. Stevens B, Croxford R, McKeever P, Yamada J, Booth M, Daub S, Gafni A, Gammon J, Greenberg M. Hospital and home chemotherapy for children with leukemia: a randomized crossover study. Pediatr Blood Cancer 2006; 47: 285-292.
  • 36. Lashlee M, O’Hanlon Curry J. Pediatric home chemotherapy: infusing “quality of life”. J Pediatr Oncol Nurs 2007; 24: 294- 298.
  • 37. Close P, Burkey E, Kazak A, Danz P, Lange B. A prospective, controlled evaluation of home chemotherapy for children with cancer. Pediatrics 1995; 95: 896-900.
  • 38. Fallowfield L, Ratcliffe D, Jenkins V, Saul J. Psychiatric morbidity and its recognition by doctors in patients with cancer. Br J Cancer 2001; 84: 1011-1015.
  • 39. Garrison CZ, Waller JL, Cuffe SP, McKeown RE, Addy CL, Jackson KL. Incidence of major depressive disorder and dysthymia in young adolescents. J Am Acad Child Adolesc Psychiatry 1997; 36: 458-465.
  • 40. Kessler RC, Walters EE. Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 1998; 7: 3-14.
  • 41. Costello EJ, Angold A, Burns BJ, Erkanli A, Stangl DK, Tweed DL. The Great Smoky Mountains Study of Youth. Functional impairment and serious emotional disturbance. Arch Gen Psychiatry 1996; 53: 1137-1143.
  • 42. Schwartz L, Drotar D. Posttraumatic stress and related impairment in survivors of childhood cancer in early adulthood compared to healthy pers. J Pediatr Psychol 2006; 31: 356-366.
  • 43. Von Essen L, Enskär K, Kreuger A, Larsson B, Sjödén PO. Selfesteem, depression and anxiety among Swedish children and adolescents on and off cancer treatment. Acta Paediatr 2000; 89: 229-236.
  • 44. Noll RB, Gartstein MA, Vannatta K, Correll J, Bukowski WM, Davies WH. Social, emotional and behavioral functioning of children with cancer. Pediatrics 1999; 103: 71-78.
  • 45. Zebrack BJ, Zeltzer LK, Whitton J. Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin’s disease and non-Hodgkin’s lymphoma: a report from the childhood cancer survivor study. Pediatrics 2002; 110: 42-52.
  • 46. Boman K, Bodegard G. Long-term coping in childhood cancer survivors: influence of illness, treatment and demographic background factors. Acta Paediatrica 2000; 89: 105-111.
  • 47. Rabineau KM, Mabe A, Vega RA. Parenting stress in pediatric oncology populations. J Pediatr Hematol Oncol 2008; 30: 358- 365.
APA SARGIN YILDIRIM N, DEMİRKAYA M, Sevinir B, güler s, VURAL A, DEMİRÖZ ABAKAY C, ÇIRPAN KANTARCIOĞLU A (2017). A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. , 1078 - 1088.
Chicago SARGIN YILDIRIM Nihal,DEMİRKAYA Metin,Sevinir Betül,güler salih,VURAL AYŞE PINAR,DEMİRÖZ ABAKAY CANDAN,ÇIRPAN KANTARCIOĞLU Arzu A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. (2017): 1078 - 1088.
MLA SARGIN YILDIRIM Nihal,DEMİRKAYA Metin,Sevinir Betül,güler salih,VURAL AYŞE PINAR,DEMİRÖZ ABAKAY CANDAN,ÇIRPAN KANTARCIOĞLU Arzu A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. , 2017, ss.1078 - 1088.
AMA SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. . 2017; 1078 - 1088.
Vancouver SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. . 2017; 1078 - 1088.
IEEE SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A "A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors." , ss.1078 - 1088, 2017.
ISNAD SARGIN YILDIRIM, Nihal vd. "A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors". (2017), 1078-1088.
APA SARGIN YILDIRIM N, DEMİRKAYA M, Sevinir B, güler s, VURAL A, DEMİRÖZ ABAKAY C, ÇIRPAN KANTARCIOĞLU A (2017). A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. Turkish Journal of Medical Sciences, 47(4), 1078 - 1088.
Chicago SARGIN YILDIRIM Nihal,DEMİRKAYA Metin,Sevinir Betül,güler salih,VURAL AYŞE PINAR,DEMİRÖZ ABAKAY CANDAN,ÇIRPAN KANTARCIOĞLU Arzu A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. Turkish Journal of Medical Sciences 47, no.4 (2017): 1078 - 1088.
MLA SARGIN YILDIRIM Nihal,DEMİRKAYA Metin,Sevinir Betül,güler salih,VURAL AYŞE PINAR,DEMİRÖZ ABAKAY CANDAN,ÇIRPAN KANTARCIOĞLU Arzu A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. Turkish Journal of Medical Sciences, vol.47, no.4, 2017, ss.1078 - 1088.
AMA SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. Turkish Journal of Medical Sciences. 2017; 47(4): 1078 - 1088.
Vancouver SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors. Turkish Journal of Medical Sciences. 2017; 47(4): 1078 - 1088.
IEEE SARGIN YILDIRIM N,DEMİRKAYA M,Sevinir B,güler s,VURAL A,DEMİRÖZ ABAKAY C,ÇIRPAN KANTARCIOĞLU A "A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors." Turkish Journal of Medical Sciences, 47, ss.1078 - 1088, 2017.
ISNAD SARGIN YILDIRIM, Nihal vd. "A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors". Turkish Journal of Medical Sciences 47/4 (2017), 1078-1088.