Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma

ERDEN, GÜL AYŞE; ÇOLAKOĞLU ER, HALE

Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma

Hale ÇOLAKOĞLU ER, (Gaziantep Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Gaziantep, Türkiye)

GÜL AYŞE ERDEN (Ankara Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2017 Cilt: 47 Sayı: 5 Sayfa Aralığı: 1520 - 1525 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma

Öz:

Background/aim: This study aimed to differentiate rectal mucinous carcinoma (MC) from nonmucinous rectal adenocarcinoma (AC) using mean apparent diffusion coefficient (mADC) values obtained with diffusion-weighted imaging. Materials and methods: Sixty-two pathologically confirmed rectal AC (n = 44) and MC (n = 18) patients were included in this study. The two groups underwent pelvic MRI to determine the local staging baseline for rectal tumors. Once the region of interest (ROI) was determined, a border was drawn around each hyperintense tumor (b = 1000 s/mm2images). Following a repeat of this procedure for each patient, the ROIs were recorded to apparent diffusion coefficient (ADC) maps, and mADC values were measured. The mADC was determined per slice, followed by a calculation of whole tumor volume ADC mean using the individual mADC values. The MannWhitney test was performed to compare mADCs for the two groups. A receiver operating characteristic (ROC) curve was generated to determine the differentiating capacity of ADCs from MC to AC. Results: The mADC was higher in MC (1.631 ± 0.375 × 10 3 mm2 /s) (range: 0.95 2.36 × 10 3 mm2 /s) than in AC (0.921 ± 0.157 × 10 3 mm2 /s) (range: 0.6 1.48 × 10 3 mm2 /s) (P < 0.001). mADCs were effective in distinguishing MC from AC (area under the ROC curve, 0.972 (95% CI : 0.928 1.00)). A threshold of 1.27 × 10 3 mm2 /s was set that corresponded with high sensitivity (94.4%) and specificity (97.7%). Twelve MCs (67%) were predominantly hypointense, and 6 MCs (33%) were seen as mixed signal intensity lesions. Forty ACs (91%) were observed as hyperintense lesions, and 4 ACs (9%) had mixed signal intensity. There was a significant difference in the signal intensities between MC and AC (c2= 54.7, P < 0.001). Conclusion: MCs and ACs show different diffusion characteristics, which can be distinguished with high sensitivity and specificity and can help to improve prognostic treatment options.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇOLAKOĞLU ER H, ERDEN G (2017). Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. , 1520 - 1525.
Chicago	ÇOLAKOĞLU ER HALE,ERDEN GÜL AYŞE Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. (2017): 1520 - 1525.
MLA	ÇOLAKOĞLU ER HALE,ERDEN GÜL AYŞE Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. , 2017, ss.1520 - 1525.
AMA	ÇOLAKOĞLU ER H,ERDEN G Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. . 2017; 1520 - 1525.
Vancouver	ÇOLAKOĞLU ER H,ERDEN G Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. . 2017; 1520 - 1525.
IEEE	ÇOLAKOĞLU ER H,ERDEN G "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma." , ss.1520 - 1525, 2017.
ISNAD	ÇOLAKOĞLU ER, HALE - ERDEN, GÜL AYŞE. "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma". (2017), 1520-1525.

APA	ÇOLAKOĞLU ER H, ERDEN G (2017). Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences, 47(5), 1520 - 1525.
Chicago	ÇOLAKOĞLU ER HALE,ERDEN GÜL AYŞE Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences 47, no.5 (2017): 1520 - 1525.
MLA	ÇOLAKOĞLU ER HALE,ERDEN GÜL AYŞE Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences, vol.47, no.5, 2017, ss.1520 - 1525.
AMA	ÇOLAKOĞLU ER H,ERDEN G Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1520 - 1525.
Vancouver	ÇOLAKOĞLU ER H,ERDEN G Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1520 - 1525.
IEEE	ÇOLAKOĞLU ER H,ERDEN G "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma." Turkish Journal of Medical Sciences, 47, ss.1520 - 1525, 2017.
ISNAD	ÇOLAKOĞLU ER, HALE - ERDEN, GÜL AYŞE. "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma". Turkish Journal of Medical Sciences 47/5 (2017), 1520-1525.