Yıl: 2017 Cilt: 47 Sayı: 6 Sayfa Aralığı: 1708 - 1714 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate

Öz:
Background/aim: Bleeding in patients undergoing coronary artery bypass grafting (CABG) while using dual antiplatelet therapy (DAPT) is a cause of significant morbidity and mortality. The aim of this study is to examine the perioperative hemostatic effects of tranexamic acid (TnX-A) and desmopressin acetate (Des) in these patients. Materials and methods: This clinical study was planned in a prospective and randomized manner. Fifty-four patients were enrolled and classified into 4 different groups. They were compared in terms of various bleeding and transfusion parameters. Results: No significant differences were observed between the groups in pre/intraoperative data apart from closure times. Plasmin/α-2 antiplasmin complex values in the TnX-A and control groups were significantly higher than those in the Des and TnX-A+Des groups at the end of postoperative drug infusion. Mean duration of closure times, first 3-h and total postoperative amounts of drainage, administered volumes of erythrocyte suspension/fresh frozen plasma, cost of blood products, length of intubation, length of stay in the intensive care unit, and time to discharge were also significantly higher in the Des and control groups. Conclusion: Des had no significant effect on bleeding control and even delayed the hemostatic efficacy of TnX-A. Use of TnX-A infusion alone in these patient groups had a positive effect on hemostasis-related data
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ALTUN G, Hemşinli D, Pulathan Z, CİVELEK A (2017). Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. , 1708 - 1714.
Chicago ALTUN Gökalp,Hemşinli Doğuş,Pulathan Zerrin,CİVELEK Ali Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. (2017): 1708 - 1714.
MLA ALTUN Gökalp,Hemşinli Doğuş,Pulathan Zerrin,CİVELEK Ali Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. , 2017, ss.1708 - 1714.
AMA ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. . 2017; 1708 - 1714.
Vancouver ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. . 2017; 1708 - 1714.
IEEE ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A "Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate." , ss.1708 - 1714, 2017.
ISNAD ALTUN, Gökalp vd. "Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate". (2017), 1708-1714.
APA ALTUN G, Hemşinli D, Pulathan Z, CİVELEK A (2017). Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. Turkish Journal of Medical Sciences, 47(6), 1708 - 1714.
Chicago ALTUN Gökalp,Hemşinli Doğuş,Pulathan Zerrin,CİVELEK Ali Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. Turkish Journal of Medical Sciences 47, no.6 (2017): 1708 - 1714.
MLA ALTUN Gökalp,Hemşinli Doğuş,Pulathan Zerrin,CİVELEK Ali Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. Turkish Journal of Medical Sciences, vol.47, no.6, 2017, ss.1708 - 1714.
AMA ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. Turkish Journal of Medical Sciences. 2017; 47(6): 1708 - 1714.
Vancouver ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate. Turkish Journal of Medical Sciences. 2017; 47(6): 1708 - 1714.
IEEE ALTUN G,Hemşinli D,Pulathan Z,CİVELEK A "Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate." Turkish Journal of Medical Sciences, 47, ss.1708 - 1714, 2017.
ISNAD ALTUN, Gökalp vd. "Emergency coronary bypass surgery in patients under the influence of dualantiplatelet therapy: effects of tranexamic acid and desmopressin acetate". Turkish Journal of Medical Sciences 47/6 (2017), 1708-1714.