Plasma cell diseases or monoclonal gammopathies are group of disorders whichoccur as a result of uncontrolled proliferation of plasma cells and over productionof immunglobulins. One of the important problems encountered in plasma celldisorders is renal diseases. Herein, we present two different cases ofglomerulonephritis which are associated with monoclonal gammopathy.study.Both the scale and the data collection sheet was applied to the students in classessor in a study environment. First case was a 51 year-old-man with anemia, acute renal failure (ARF) andisolated microscopic hematuria whom were referred to nephrology outpatientclinic. He had no history of hypertension (HT), diabetes mellitus (DM), renaldisease and nephrotoxic drug usage. Renal biopsy was done and diagnosed asC3 glomerulonephritis (C3GN).Second case was a 69 year-old-man whom had a history of chronic renal failure(CRF), HT, DM and chronic ischemic heart disease. He had a progressivelyincreased proteinuria for a one year during the nephrology outpatient clinicfollow-up. He had nephrotic proteinuria and no hematuria. Atypicalproteinuria was considered. Renal biopsy was done and diagnosed asmembranoproliferative glomerulonephritis (MPGN).Both of the cases were investigated for monoclonal gammopathy during theinpatient clinic follow-up. A sharp band was detected in protein electrophoresisand IgG-Kappa monoclonal gammopathy was observed in immunfixation inboth of the cases. Bone marrow aspiration and biopsy were done and diagnosedas multiple myeloma.The circulating paraproteins cause a diversity of kidney diseases and they canaffect the glomeruli especially. If patient is diagnosed as MPGN or C3GN,secondary reasons including the monoclonal gammopathies must be absolutelyinvestigated.