Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer

AYDIN, FUNDA; BUDAK, Evrim Sürer; ÇEVİKOL, Can; ŞİMŞEK, Tayup; ÖNER, Ali Ozan; Toptas, Tayfun

Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer

Evrim Sürer BUDAK, (Antalya Training and Research Hospital, Clinic of Nuclear Medicine, Antalya, Turkey)

Tayfun TOPTAŞ, (Akdeniz University Faculty of Medicine, Department of Gynecologic Oncological Surgery, Antalya, Turkey)

Funda AYDIN, (Akdeniz University Faculty of Medicine, Department of Nuclear Medicine, Antalya, Turkey)

Ali Ozan ÖNER, (Afyon Kocatepe University Faculty of Medicine, Department of Nuclear Medicine, Afyonkarahisar, Turkey)

Can ÇEVİKOL, (Akdeniz University Faculty of Medicine, Department of Radiology, Antalya, Turkey)

Tayup ŞİMŞEK (Akdeniz University Faculty of Medicine, Department of Gynecologic Oncological Surgery, Antalya, Turkey)

Molecular Imaging and Radionuclide Therapy

4 3

Yıl: 2017 Cilt: 26 Sayı: 1 Sayfa Aralığı: 24 - 32 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer

Öz:

Amaç: Endometrium kanserinde (EK) primer tümörün maksimum standardize tutulum değeri (SUVmaks) ve minimum görünen difüzyon katsayısının (ADCmin) klinikopatolojik özellikler ile olan ilişkisini araştırmak ve bunların öngörü gücünü belirlemektir.Yöntem: 18F-fluorodeoksiglukoz (FDG) pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) ve difüzyon ağırlıklımanyetik rezonans görüntüleme (DA-MRG) ile preoperatif değerlendirmeyi takiben evreleme cerrahisi yapılan toplamda 45 hasta, planlı veri toplama yapılan prospektif bir olgu serisine dahil edildiler. Çalışma verileri arasındaki ilişkiler çoklu doğrusal regresyon analizi ile araştırıldı.Bulgular: Ortalama ADCmin ve SUVmaks sırasıyla 0,72±0,22 ve 16,54±8,73 olarak bulundu. Tek değişkenli analizde yaş, myometriyal invazyon (Mİ) ve lenfovasküler alan tutulumu (LVAT) ADCmin ile ilişkili potansiyel faktörler olarak bulunurken, yaş, evre, tümör büyüklüğü, LVAT ve metastatik lenf düğümlerinin sayısı SUVmaks ile ilişkili potansiyel değişkenler olarak tespit edildiler. Diğer taraftan, çok değişkenli analizde Mİ, ADCmin (p=0,007) ve SUVmaks (p=0,024) ile ilişkili tek anlamlı değişkendi. Derin Mİ en iyi, <=0,77'lik [%93,7 duyarlılık, %48,2 özgüllük ve %93,0 negatif öngörü değeri (NPD)] bir ADCmin kesim değeri ve >20,5'lik (%62,5 duyarlılık, %86,2 özgüllük ve %81,0 NPD) bir SUVmaks kesim değeri ile öngörülebiliyordu. Ne var ki, her iki tanısal test birbirlerinden anlamlı şekilde farklı değildi (p=0,266).Sonuç: Klinikopatolojik özelliklerden yalnızca Mİ bağımsız ve anlamlı şekilde SUVmaks ve ADCmin ile ilişkiliydi. Ne var ki, her iki parametrenin ideal olmayan öngörü performansları nedeniyle 18F-FDG PET/BT veya DA-MRG'nin rutin kullanımı şu noktada önerilemez.

Anahtar Kelime:

Konular: Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme

Endometrium Kanserinde Primer Tümöre Ait Minimum Görünen Difüzyon Katsayısı ve Maksimum Standardize Tutulum Değerleri ile Klinikopatolojik Özelliklerin İlişkisi

Öz:

Objective: To explore the correlation of the primary tumor's maximum standardized uptake value (SUVmax) and minimum apparent diffusion coefficient (ADCmin) with clinicopathologic features, and to determine their predictive power in endometrial cancer (EC). Methods: A total of 45 patients who had undergone staging surgery after a preoperative evaluation with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) were included in a prospective case-series study with planned data collection. Multiple linear regression analysis was used to determine the correlations between the study variables.Results: The mean ADCmin and SUVmax values were determined as 0.72±0.22 and 16.54±8.73, respectively. A univariate analysis identified age, myometrial invasion (MI) and lymphovascular space involvement (LVSI) as the potential factors associated with ADCmin while it identified age, stage, tumor size, MI, LVSI and number of metastatic lymph nodes as the potential variables correlated to SUVmax. In multivariate analysis, on the other hand, MI was the only significant variable that correlated with ADCmin (p=0.007) and SUVmax (p=0.024). Deep MI was best predicted by an ADCmin cutoff value of <=0.77 [93.7% sensitivity, 48.2% specificity, and 93.0% negative predictive value (NPV)] and SUVmax cutoff value of >20.5 (62.5% sensitivity, 86.2% specificity, and 81.0% NPV); however, the two diagnostic tests were not significantly different (p=0.266).Conclusion: Among clinicopathologic features, only MI was independently correlated with SUVmax and ADCmin. However, the routine use of 18F-FDG PET/CT or DW-MRI cannot be recommended at the moment due to less than ideal predictive performances of both parameters.

Anahtar Kelime:

Konular: Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BUDAK E, Toptas T, AYDIN F, ÖNER A, ÇEVİKOL C, ŞİMŞEK T (2017). Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. , 24 - 32.
Chicago	BUDAK Evrim Sürer,Toptas Tayfun,AYDIN FUNDA,ÖNER Ali Ozan,ÇEVİKOL Can,ŞİMŞEK Tayup Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. (2017): 24 - 32.
MLA	BUDAK Evrim Sürer,Toptas Tayfun,AYDIN FUNDA,ÖNER Ali Ozan,ÇEVİKOL Can,ŞİMŞEK Tayup Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. , 2017, ss.24 - 32.
AMA	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. . 2017; 24 - 32.
Vancouver	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. . 2017; 24 - 32.
IEEE	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T "Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer." , ss.24 - 32, 2017.
ISNAD	BUDAK, Evrim Sürer vd. "Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer". (2017), 24-32.

APA	BUDAK E, Toptas T, AYDIN F, ÖNER A, ÇEVİKOL C, ŞİMŞEK T (2017). Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Molecular Imaging and Radionuclide Therapy, 26(1), 24 - 32.
Chicago	BUDAK Evrim Sürer,Toptas Tayfun,AYDIN FUNDA,ÖNER Ali Ozan,ÇEVİKOL Can,ŞİMŞEK Tayup Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Molecular Imaging and Radionuclide Therapy 26, no.1 (2017): 24 - 32.
MLA	BUDAK Evrim Sürer,Toptas Tayfun,AYDIN FUNDA,ÖNER Ali Ozan,ÇEVİKOL Can,ŞİMŞEK Tayup Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Molecular Imaging and Radionuclide Therapy, vol.26, no.1, 2017, ss.24 - 32.
AMA	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Molecular Imaging and Radionuclide Therapy. 2017; 26(1): 24 - 32.
Vancouver	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Molecular Imaging and Radionuclide Therapy. 2017; 26(1): 24 - 32.
IEEE	BUDAK E,Toptas T,AYDIN F,ÖNER A,ÇEVİKOL C,ŞİMŞEK T "Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer." Molecular Imaging and Radionuclide Therapy, 26, ss.24 - 32, 2017.
ISNAD	BUDAK, Evrim Sürer vd. "Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer". Molecular Imaging and Radionuclide Therapy 26/1 (2017), 24-32.