PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY

Atasoy, Pınar; YUVANÇ, ERCAN; Kisa, Ucler; BAL, FATİH; Tuğlu, Devrim; YILMAZ, ERDAL; Batislam, Ertan

PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY

Devrim TUĞLU, (Kırıkkale University Faculty of Medicine, Department of Urology, KIRIKKALE)

Ercan YUVANÇ, (Kırıkkale University Faculty of Medicine, Department of Urology, KIRIKKALE)

Fatih BAL, (Kırıkkale University Faculty of Medicine, Department of Urology, KIRIKKALE)

Erdal YILMAZ, (Kırıkkale University Faculty of Medicine, Department of Urology, KIRIKKALE)

Pınar ATASOY, (Kırıkkale University, Faculty of Medicine, Department of Pathology, KIRIKKALE)

Üçler KISA, (Kırıkkale University, Faculty of Medicine, Department of Medical Biochemistry, KIRIKKALE)

Ertan BATİSLAM (Kırıkkale University Faculty of Medicine, Department of Urology, KIRIKKALE)

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2017 Cilt: 19 Sayı: 1 Sayfa Aralığı: 8 - 16 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY

Öz:

Amaç: Çalışmamızda amacımız, testiste iskemi/reperfüsyon (I/R) etkisi ile oluşan oksidatif hasar üzerine pirasetamın koruyucu etkilerini araştırmaktır. Gereç ve Yöntemler: Ratlar rastgele 4 gruba ayrıldı. Grup 1= sham (kontrol), Grup 2=I/R (iskemi/reperfüsyon), Grup 3=I/R+pirasetam (250 mg/kg; i.p.) ve Grup 4=I/R+pirasetam (500 mg/kg; i.p.). Pirasetam intraperitoneal yolla testis torsiyonunu takiben 60. dakikada verilmiştir. Her 4 grupta işlemin başlangıcından 6 saat sonra ipsilateral sol testis ve kontralateral sağ testisler çıkarılmıştır. Bulgular: Pirasetam uygulaması total antioksidan kapasiteyi istatistiksel olarak anlamlı biçimde arttırırken, oksidatif stres indeks oranını da istatistiksel olarak anlamlı biçimde azaltmıştır. İpsilateral ve kontralateral testis grupları arasında Johnsen skorlama sistemine göre istatistiksel farklılık saptanmamıştır. Sonuç: Pirasetam uygulaması, testislerde iskemi reperfüzyon ile oluşan oksidatif hasarı antioksidan kapasiteyi arttırarak ve oksidatif stres skorlarını düşürerek azaltmıştır; ancak, histopatolojik incelemede ve spermatogenes skorlarında bir değişime neden olmamıştır.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Ratlarda Sistemik Pirasetam Tedavisinin Testis Torsiyon/Detorsiyon Hasarında Koruyucu Etkileri: Doz Bağımlı Çalışma

Öz:

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tuğlu D, YUVANÇ E, BAL F, YILMAZ E, Atasoy P, Kisa U, Batislam E (2017). PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. , 8 - 16.
Chicago	Tuğlu Devrim,YUVANÇ ERCAN,BAL FATİH,YILMAZ ERDAL,Atasoy Pınar,Kisa Ucler,Batislam Ertan PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. (2017): 8 - 16.
MLA	Tuğlu Devrim,YUVANÇ ERCAN,BAL FATİH,YILMAZ ERDAL,Atasoy Pınar,Kisa Ucler,Batislam Ertan PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. , 2017, ss.8 - 16.
AMA	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. . 2017; 8 - 16.
Vancouver	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. . 2017; 8 - 16.
IEEE	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E "PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY." , ss.8 - 16, 2017.
ISNAD	Tuğlu, Devrim vd. "PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY". (2017), 8-16.

APA	Tuğlu D, YUVANÇ E, BAL F, YILMAZ E, Atasoy P, Kisa U, Batislam E (2017). PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 19(1), 8 - 16.
Chicago	Tuğlu Devrim,YUVANÇ ERCAN,BAL FATİH,YILMAZ ERDAL,Atasoy Pınar,Kisa Ucler,Batislam Ertan PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 19, no.1 (2017): 8 - 16.
MLA	Tuğlu Devrim,YUVANÇ ERCAN,BAL FATİH,YILMAZ ERDAL,Atasoy Pınar,Kisa Ucler,Batislam Ertan PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, vol.19, no.1, 2017, ss.8 - 16.
AMA	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi. 2017; 19(1): 8 - 16.
Vancouver	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi. 2017; 19(1): 8 - 16.
IEEE	Tuğlu D,YUVANÇ E,BAL F,YILMAZ E,Atasoy P,Kisa U,Batislam E "PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY." Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 19, ss.8 - 16, 2017.
ISNAD	Tuğlu, Devrim vd. "PROTECTIVE EFFECTS OF SYSTEMIC PIRACETAM TREATMENT ON TESTICULAR TORSION/DETORSION DAMAGE IN RATS: A DOSE-RESPONSE STUDY". Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 19/1 (2017), 8-16.