Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

Yalcin, Basak; DOĞAN GÜNAYDIN, SİBEL; Yorulmaz, Ahu; Artüz, Refika Ferda; ATAKAN, ZEHRA NİLGÜN

Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

SİBEL DOĞAN GÜNAYDIN, (Hacettepe University)

Başak YALÇIN, (Yıldırım Beyazıt University)

ZEHRA NİLGÜN ATAKAN, (Hacettepe University)

Ahu YORULMAZ, (Clinic of Dermatology and Venereology, Ankara Numune Training and Research Hospital, Ankara, Turkey)

Ferda ARTÜZ (Clinic of Dermatology and Venereology, Ankara Numune Training and Research Hospital, Ankara, Turkey)

Journal of Experimental and Clinical Medicine

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Yıl: 2017 Cilt: 34 Sayı: 2 Sayfa Aralığı: 83 - 87 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

Öz:

Behçet’s disease (BD) is a severe inflammatory vasculitis which is very common among Turkish population. Recently, IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be associated with several inflammatory diseases. In this study, we investigated the association of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms with BD and their probable implications on clinical manifestations of BD in a Turkish patient cohort. 116 patients and 150 healthy controls genomic DNA were studied. Allele-specific primers were used for genotyping. No significant difference was found between patient and controls according to genotypic distribution and allelic frequencies of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) (p>0.05). No statistically significant difference was found in genotypic or allellic distribution of the same polymorphisms according to gender or clinical characteristics between patients and controls (p>0.05). Our study is to our knowledge the first report from Turkey regarding BD and IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms. IRGM gene polymorphisms seems to cause predilection for autoimmunity in certain ethnic groups but not in Turkish BD patients. CARD8 gene polymorphisms and other inflammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DOĞAN GÜNAYDIN S, Yalcin B, ATAKAN Z, Yorulmaz A, Artüz R (2017). Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. , 83 - 87.
Chicago	DOĞAN GÜNAYDIN SİBEL,Yalcin Basak,ATAKAN ZEHRA NİLGÜN,Yorulmaz Ahu,Artüz Refika Ferda Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. (2017): 83 - 87.
MLA	DOĞAN GÜNAYDIN SİBEL,Yalcin Basak,ATAKAN ZEHRA NİLGÜN,Yorulmaz Ahu,Artüz Refika Ferda Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. , 2017, ss.83 - 87.
AMA	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. . 2017; 83 - 87.
Vancouver	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. . 2017; 83 - 87.
IEEE	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R "Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey." , ss.83 - 87, 2017.
ISNAD	DOĞAN GÜNAYDIN, SİBEL vd. "Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey". (2017), 83-87.

APA	DOĞAN GÜNAYDIN S, Yalcin B, ATAKAN Z, Yorulmaz A, Artüz R (2017). Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine, 34(2), 83 - 87.
Chicago	DOĞAN GÜNAYDIN SİBEL,Yalcin Basak,ATAKAN ZEHRA NİLGÜN,Yorulmaz Ahu,Artüz Refika Ferda Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine 34, no.2 (2017): 83 - 87.
MLA	DOĞAN GÜNAYDIN SİBEL,Yalcin Basak,ATAKAN ZEHRA NİLGÜN,Yorulmaz Ahu,Artüz Refika Ferda Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine, vol.34, no.2, 2017, ss.83 - 87.
AMA	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine. 2017; 34(2): 83 - 87.
Vancouver	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine. 2017; 34(2): 83 - 87.
IEEE	DOĞAN GÜNAYDIN S,Yalcin B,ATAKAN Z,Yorulmaz A,Artüz R "Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey." Journal of Experimental and Clinical Medicine, 34, ss.83 - 87, 2017.
ISNAD	DOĞAN GÜNAYDIN, SİBEL vd. "Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey". Journal of Experimental and Clinical Medicine 34/2 (2017), 83-87.