Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis
Yıl: 2017 Cilt: 39 Sayı: 2 Sayfa Aralığı: 63 - 66 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis
Öz: Objective: Major causes of mortality in patients with valvular disease are endocarditis and valve thrombosis. Oral anticoagulant drugs are used to prevent valve thrombosis. Uses of inadequate doses of medication or absence of medication use are the main reasons for the development of valve thrombosis. In addition to medical treatment or surgical treatment of patients with infective endocarditis has a high mortality rate. In this study, MTHFR C677T, Prothrombin (Factor-II) G20210A, Factor-V Leiden G1631, PAI-1 4G/5G and TNF-α-308 G>A were determined in patients with infective endocarditis and valve thrombosis groups. Materials and Methods: 18 patients with infective endocarditis, 12 patients with valve thrombosis and 37 healthy volunteers were included in this study. Polymerase chain reactions (PCR) and restriction fragment length polymorphisms (RFLP) were used to detect the related polymorphism. Chi-square was used to compare groups. Results: There were no significant differences between the groups regarding MTHFR C677T, Prothrombin (Factor-II) G20210A, Factor-V Leiden G1631, PAI-1 4G/5G polymorphism. In contrast, a significant difference was found in TNF-α -308 G>A polymorphism between the groups. Conclusion: In our study, TNF-α-308 G>A results were higher in patients with endocarditis and valve thrombosis than control groups in chi-squares test and there were significant differences between two groups. There is not enough data in literature about the involvement of genetic factors in valve thrombosis. For this reason, larger and more comprehensive studies are needed
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | TUNÇAY A, Sener E, EMİROĞULLARI Ö (2017). Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. , 63 - 66. |
| Chicago | TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. (2017): 63 - 66. |
| MLA | TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. , 2017, ss.63 - 66. |
| AMA | TUNÇAY A,Sener E,EMİROĞULLARI Ö Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. . 2017; 63 - 66. |
| Vancouver | TUNÇAY A,Sener E,EMİROĞULLARI Ö Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. . 2017; 63 - 66. |
| IEEE | TUNÇAY A,Sener E,EMİROĞULLARI Ö "Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis." , ss.63 - 66, 2017. |
| ISNAD | TUNÇAY, AYDIN vd. "Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis". (2017), 63-66. |
| APA | TUNÇAY A, Sener E, EMİROĞULLARI Ö (2017). Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. Erciyes Medical Journal, 39(2), 63 - 66. |
| Chicago | TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. Erciyes Medical Journal 39, no.2 (2017): 63 - 66. |
| MLA | TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. Erciyes Medical Journal, vol.39, no.2, 2017, ss.63 - 66. |
| AMA | TUNÇAY A,Sener E,EMİROĞULLARI Ö Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. Erciyes Medical Journal. 2017; 39(2): 63 - 66. |
| Vancouver | TUNÇAY A,Sener E,EMİROĞULLARI Ö Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis. Erciyes Medical Journal. 2017; 39(2): 63 - 66. |
| IEEE | TUNÇAY A,Sener E,EMİROĞULLARI Ö "Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis." Erciyes Medical Journal, 39, ss.63 - 66, 2017. |
| ISNAD | TUNÇAY, AYDIN vd. "Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis". Erciyes Medical Journal 39/2 (2017), 63-66. |
