Allergic and autoimmune disorders in families with selective IgA deficiency

Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. Results: The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of 5% in the general population. Conclusion: Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible common predisposing genetic component for sIgAD and autoimmunity in these families.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Yel L. Selective IgA deficiency. J Clin Immunol 2010; 30: 10-16.
2. Hanson LA, Bjorkander J, Carlsson B, Roberton D, Soderstrom T. The heterogeneity of IgA deficiency. J Clin Immunol 1988; 8: 159-162.
3. Burrows PD, Cooper MD. IgA deficiency. Adv Immunol 1997; 65: 245-276.
4. Aytekin C, Tuygun N, Gokce S, Dogu F, Ikinciogullari A. Selective IgA deficiency: clinical and laboratory features of 118 children in Turkey. J Clin Immunol 2012; 32: 961-966.
5. Mantis NJ, Rol N, Corthesy B. Secretory IgAs complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol 2011; 4: 603-611.
6. Janzi M, Kull I, Sjoberg R, Wan J, Melen E, Bayat N, Ostblom E, Pan-Hammarstrom Q, Nilsson P, Hammarstrom L. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol 2009; 133: 78-85.
7. Aghamohammadi A, Cheraghi T, Gharagozlou M, Movahedi M, Rezaei N, Yeganeh M, Parvaneh N, Abolhassani H, Pourpak Z, Moin M. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol 2009; 29: 130-136.
8. Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmune diseases in Denmark. J Autoimmun 2007; 29: 1-9.
9. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev 2003; 2: 119-125.
10. Edwards E, Razvi S, Cunningham-Rundles C. IgA deficiency: clinical correlates and responses to pneumococcal vaccine. Clin Immunol 2004; 111: 93-97.
11. Ryser O, Morell A, Hitzig WH. Primary immunodeficiencies in Switzerland: first report of the national registry in adults and children. J Clin Immunol 1988; 8: 479-485.
12. Heneghan MA, Stevens FM, Cryan EM, Warner RH, McCarthy CF. Celiac sprue and immunodeficiency states: a 25-year review. J Clin Gastroenterol 1997; 25: 421-425.
13. Meini A, Pillan NM, Villanacci V, Monafo V, Ugazio AG, Plebani A. Prevalence and diagnosis of celiac disease in IgAdeficient children. Ann Allergy Asthma Immunol 1996; 77: 333-336.
14. Hammarstrom L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol 2000; 120: 225-231.
15. Jorgensen GH, Thorsteinsdottir I, Gudmundsson S, Hammarstrom L, Ludviksson BR. Familial aggregation of IgAD and autoimmunity. Clin Immunol 2009; 131: 233-239.
16. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, OByrne P, Pedersen SE et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143-178.
17. Brenninkmeijer EE, Schram ME, Leeflang MM, Bos JD, Spuls PI. Diagnostic criteria for atopic dermatitis: a systematic review. Br J Dermatol 2008; 158: 754-765.
18. Buckley RH. Clinical and immunologic features of selective IgA deficiency. Birth Defects Orig Artic Ser 1975; 11: 134-142.
19. Civelek E, Cakir B, Boz AB, Yuksel H, Orhan F, Uner A, Sekerel BE. Extent and burden of allergic diseases in elementary schoolchildren: a national multicenter study. J Investig Allergol Clin Immunol 2010; 20: 280-288.
20. Woof JM, Kerr MA. The function of immunoglobulin A in immunity. J Pathol 2006; 208: 270-282.
21. Gleeson M, Cripps AW, Clancy RL, Hensley MJ, Henry RJ, Wlodarczyk JH. The significance of transient mucosal IgA deficiency on the development of asthma and atopy in children. Adv Exp Med Biol 1995; 371B: 861-864.
22. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, Printz MC, Lee WM, Shult PA, Reisdorf E et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-672.
23. Baştürk B, Sarı S, Aral A, Dalgıç B. Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children. Turk J Pediatr 2011; 53: 364-368.
24. Wang N, Shen N, Vyse TJ, Anand V, Gunnarson I, Sturfelt G, Rantapaa-Dahlqvist S, Elvin K, Truedsson L, Andersson BA et al. Selective IgA deficiency in autoimmune diseases. Mol Med 2011; 17: 1383-1396.
25. Singh K, Chang C, Gershwin ME. IgA deficiency and autoimmunity. Autoimmun Rev 2014; 13: 163-177.
26. Abolhassani H, Gharib B, Shahinpour S, Masoom SN, Havaei A, Mirminachi B, Arandi N, Torabi-Sagvand B, Khazaei HA, Mohammadi J et al. Autoimmunity in patients with selective IgA deficiency. J Investig Allergol Clin Immunol 2015; 25: 112- 119.
27. Liblau RS, Bach JF. Selective IgA deficiency and autoimmunity. Int Arch Allergy Immunol 1992; 99: 16-27.
28. Jacob CM, Pastorino AC, Fahl K, Carneiro-Sampaio M, Monteiro RC. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol 2008; 28 Suppl 1: S56-61.
29. Capkin E, Cakirbay H, Karkucak M, Topbas M, Serdaroglu M, Guler M, Tosun M. Prevalence of rheumatoid arthritis in the eastern Black Sea region of Turkey. Int J Rheum Dis 2010; 13: 380-384.
30. Ozen S, Karaaslan Y, Ozdemir O, Saatci U, Bakkaloglu A, Koroglu E, Tezcan S. Prevalence of juvenile chronic arthritis and familial Mediterranean fever in Turkey: a field study. J Rheumatol 1998; 25: 2445-2449.
31. Cataldo F, Marino V, Bottaro G, Greco P, Ventura A. Celiac disease and selective immunoglobulin A deficiency. J Pediatr 1997; 131: 306-308.
32. Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A, Baris Z, Turkish Celiac Study Group. Prevalence of celiac disease in healthy Turkish school children. Am J Gastroenterol 2011; 106: 1512-1517.
33. Klemola T, Savilahti E, Koskimies S, Pelkonen P. HLA antigens in IgA deficient paediatric patients. Tissue Antigens 1988; 32: 218-223.
34. Clerici N, Fernandez M, Saiz I, Sainz T, Polanco I. Human leukocyte antigen alleles and haplotypes associated with selective immunoglobulin A deficiency in Spanish pediatric patients. J Pediatr Gastroenterol Nutr 1993; 16: 381-386.
35. Cunningham-Rundles C. Hematologic complications of primary immune deficiencies. Blood Rev 2002; 16: 61-64.
36. Gerbase-Delima M, Pinto LC, Grumach A, Carneiro-Sampaio MM. HLA antigens and haplotypes in IgA-deficient Brazilian paediatric patients. Eur J Immunogenet 1998; 25: 281-285.
37. De la Concha EG, Fernandez-Arquero M, Gual L, Vigil P, Martinez A, Urcelay E, Ferreira A, Garcia-Rodriguez MC, Fontan G. MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes. J Immunol 2002; 169: 4637-4643.
38. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 2005; 37: 829-834.

APA	ERKOÇOĞLU M, metin karakas a, KAYA A, Özcan C, AKAN A, CİVELEK E, capanoglu m, GİNİŞ T, KOCABAŞ C (2017). Allergic and autoimmune disorders in families with selective IgA deficiency. , 592 - 598.
Chicago	ERKOÇOĞLU Mustafa,metin karakas ayşe,KAYA AYŞENUR,Özcan Celal,AKAN AYŞEGÜL,CİVELEK ERSOY,capanoglu murat,GİNİŞ Tayfur,KOCABAŞ CAN NACİ Allergic and autoimmune disorders in families with selective IgA deficiency. (2017): 592 - 598.
MLA	ERKOÇOĞLU Mustafa,metin karakas ayşe,KAYA AYŞENUR,Özcan Celal,AKAN AYŞEGÜL,CİVELEK ERSOY,capanoglu murat,GİNİŞ Tayfur,KOCABAŞ CAN NACİ Allergic and autoimmune disorders in families with selective IgA deficiency. , 2017, ss.592 - 598.
AMA	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C Allergic and autoimmune disorders in families with selective IgA deficiency. . 2017; 592 - 598.
Vancouver	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C Allergic and autoimmune disorders in families with selective IgA deficiency. . 2017; 592 - 598.
IEEE	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C "Allergic and autoimmune disorders in families with selective IgA deficiency." , ss.592 - 598, 2017.
ISNAD	ERKOÇOĞLU, Mustafa vd. "Allergic and autoimmune disorders in families with selective IgA deficiency". (2017), 592-598.

APA	ERKOÇOĞLU M, metin karakas a, KAYA A, Özcan C, AKAN A, CİVELEK E, capanoglu m, GİNİŞ T, KOCABAŞ C (2017). Allergic and autoimmune disorders in families with selective IgA deficiency. Turkish Journal of Medical Sciences, 47(2), 592 - 598.
Chicago	ERKOÇOĞLU Mustafa,metin karakas ayşe,KAYA AYŞENUR,Özcan Celal,AKAN AYŞEGÜL,CİVELEK ERSOY,capanoglu murat,GİNİŞ Tayfur,KOCABAŞ CAN NACİ Allergic and autoimmune disorders in families with selective IgA deficiency. Turkish Journal of Medical Sciences 47, no.2 (2017): 592 - 598.
MLA	ERKOÇOĞLU Mustafa,metin karakas ayşe,KAYA AYŞENUR,Özcan Celal,AKAN AYŞEGÜL,CİVELEK ERSOY,capanoglu murat,GİNİŞ Tayfur,KOCABAŞ CAN NACİ Allergic and autoimmune disorders in families with selective IgA deficiency. Turkish Journal of Medical Sciences, vol.47, no.2, 2017, ss.592 - 598.
AMA	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C Allergic and autoimmune disorders in families with selective IgA deficiency. Turkish Journal of Medical Sciences. 2017; 47(2): 592 - 598.
Vancouver	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C Allergic and autoimmune disorders in families with selective IgA deficiency. Turkish Journal of Medical Sciences. 2017; 47(2): 592 - 598.
IEEE	ERKOÇOĞLU M,metin karakas a,KAYA A,Özcan C,AKAN A,CİVELEK E,capanoglu m,GİNİŞ T,KOCABAŞ C "Allergic and autoimmune disorders in families with selective IgA deficiency." Turkish Journal of Medical Sciences, 47, ss.592 - 598, 2017.
ISNAD	ERKOÇOĞLU, Mustafa vd. "Allergic and autoimmune disorders in families with selective IgA deficiency". Turkish Journal of Medical Sciences 47/2 (2017), 592-598.