Association of B7-H4 gene polymorphisms in urothelial bladder cancer

sağlıcan, yeşim; Samli, M. Murat; ÖZGÖZ, Asuman; ŞAMLI, HALE; ŞAHİN, Ahmet; BALCI, Faruk; ince, umit; DİNÇEL, DENİZ

Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Asuman ÖZGÖZ, (Kastamonu Üniversitesi Sağlık Bilimleri Fakültesi, Fazıl Boyner Beslenme ve Diyetetik Bölümü, Kastamonu, Türkiye)

Murat ŞAMLI, (Acıbadem Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Deniz DİNÇEL, (Uludağ Üniversitesi Veteriner Fakültesi Genetik Anabilim Dalı, Bursa, Türkiye)

Ahmet ŞAHİN, (Acıbadem Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Ümit İNCE, (Acıbadem Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Yeşim SAĞLICAN, (Acıbadem Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Faruk BALCI, (Uludağ Üniversitesi Veteriner Fakültesi Genetik Anabilim Dalı, Bursa, Türkiye)

Hale ŞAMLI (Uludağ Üniversitesi Veteriner Fakültesi Genetik Anabilim Dalı, Bursa, Türkiye)

Turkish Journal of Medical Sciences

3 0

Yıl: 2017 Cilt: 47 Sayı: 2 Sayfa Aralığı: 443 - 446 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Öz:

Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZGÖZ A, Samli M, DİNÇEL D, ŞAHİN A, ince u, sağlıcan y, BALCI F, ŞAMLI H (2017). Association of B7-H4 gene polymorphisms in urothelial bladder cancer. , 443 - 446.
Chicago	ÖZGÖZ Asuman,Samli M. Murat,DİNÇEL DENİZ,ŞAHİN Ahmet,ince umit,sağlıcan yeşim,BALCI Faruk,ŞAMLI HALE Association of B7-H4 gene polymorphisms in urothelial bladder cancer. (2017): 443 - 446.
MLA	ÖZGÖZ Asuman,Samli M. Murat,DİNÇEL DENİZ,ŞAHİN Ahmet,ince umit,sağlıcan yeşim,BALCI Faruk,ŞAMLI HALE Association of B7-H4 gene polymorphisms in urothelial bladder cancer. , 2017, ss.443 - 446.
AMA	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H Association of B7-H4 gene polymorphisms in urothelial bladder cancer. . 2017; 443 - 446.
Vancouver	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H Association of B7-H4 gene polymorphisms in urothelial bladder cancer. . 2017; 443 - 446.
IEEE	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H "Association of B7-H4 gene polymorphisms in urothelial bladder cancer." , ss.443 - 446, 2017.
ISNAD	ÖZGÖZ, Asuman vd. "Association of B7-H4 gene polymorphisms in urothelial bladder cancer". (2017), 443-446.

APA	ÖZGÖZ A, Samli M, DİNÇEL D, ŞAHİN A, ince u, sağlıcan y, BALCI F, ŞAMLI H (2017). Association of B7-H4 gene polymorphisms in urothelial bladder cancer. Turkish Journal of Medical Sciences, 47(2), 443 - 446.
Chicago	ÖZGÖZ Asuman,Samli M. Murat,DİNÇEL DENİZ,ŞAHİN Ahmet,ince umit,sağlıcan yeşim,BALCI Faruk,ŞAMLI HALE Association of B7-H4 gene polymorphisms in urothelial bladder cancer. Turkish Journal of Medical Sciences 47, no.2 (2017): 443 - 446.
MLA	ÖZGÖZ Asuman,Samli M. Murat,DİNÇEL DENİZ,ŞAHİN Ahmet,ince umit,sağlıcan yeşim,BALCI Faruk,ŞAMLI HALE Association of B7-H4 gene polymorphisms in urothelial bladder cancer. Turkish Journal of Medical Sciences, vol.47, no.2, 2017, ss.443 - 446.
AMA	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H Association of B7-H4 gene polymorphisms in urothelial bladder cancer. Turkish Journal of Medical Sciences. 2017; 47(2): 443 - 446.
Vancouver	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H Association of B7-H4 gene polymorphisms in urothelial bladder cancer. Turkish Journal of Medical Sciences. 2017; 47(2): 443 - 446.
IEEE	ÖZGÖZ A,Samli M,DİNÇEL D,ŞAHİN A,ince u,sağlıcan y,BALCI F,ŞAMLI H "Association of B7-H4 gene polymorphisms in urothelial bladder cancer." Turkish Journal of Medical Sciences, 47, ss.443 - 446, 2017.
ISNAD	ÖZGÖZ, Asuman vd. "Association of B7-H4 gene polymorphisms in urothelial bladder cancer". Turkish Journal of Medical Sciences 47/2 (2017), 443-446.