MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome

Background: Down syndrome, which is the most common human chromosomal anomaly that can affect people of any race and age, can be diagnosed prenatally in most cases. Prenatal diagnosis via culture method is time-consuming; thus, genetic analysis has thus been introduced and is continually being developed for rapid prenatal diagnosis. For this reason, the effective use of microRNA profiling for the rapid analysis of prenatal amniotic fluid samples for the diagnosis of Down syndrome was investigated. Aims: To evaluate the expression levels of 14 microRNAs encoded by chromosome 21 in amniotic fluid samples and their utility for prenatal diagnosis of Down syndrome. Study Design: Case-control study. Methods: We performed invasive prenatal testing for 56 pregnant women; 23 carried fetuses with Down syndrome, and 33 carriedfetuses with a normal karyotype. Advanced maternal age and increased risk for Down syndrome in the screening tests were indications for invasive prenatal testing. The age of gestation in the study and control groups ranged between 17 and 18 weeks. The expression levels of microRNA were measured by real-time polymerase chain reaction. Results: The expression levels of microRNA-125b-2, microRNA-155, and microRNA-3156 were significantly higher in the study group than in the control group. Conclusion: The presence of significantly dysregulated microRNAs may be associated with either the phenotype or the result of abnormal development. Further large-scale comparative studies conducted in a variety of conditions may bring novel insights in the field of abnormal prenatal conditions

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Karaca E, aykut a, ERTÜRK B, DURMAZ M, Güler A, BÜKE B, Yeniel A, ERGENOĞLU A, ÖZKINAY F, OZEREN M, Kazandı M, Akercan F, Sağol S, Gunduz C, ÇOĞULU M (2018). MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. , 163 - 166.
Chicago	Karaca Emin,aykut ayca,ERTÜRK Biray,DURMAZ MEHMET BURAK,Güler Ahmet,BÜKE Barış,Yeniel Ahmet Ozgur,ERGENOĞLU Ahmet Mete,ÖZKINAY FERİŞTAH FERDA,OZEREN MEHMET,Kazandı Mert,Akercan Fuat,Sağol Sermet,Gunduz Cumhur,ÇOĞULU MUHSİN ÖZGÜR MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. (2018): 163 - 166.
MLA	Karaca Emin,aykut ayca,ERTÜRK Biray,DURMAZ MEHMET BURAK,Güler Ahmet,BÜKE Barış,Yeniel Ahmet Ozgur,ERGENOĞLU Ahmet Mete,ÖZKINAY FERİŞTAH FERDA,OZEREN MEHMET,Kazandı Mert,Akercan Fuat,Sağol Sermet,Gunduz Cumhur,ÇOĞULU MUHSİN ÖZGÜR MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. , 2018, ss.163 - 166.
AMA	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. . 2018; 163 - 166.
Vancouver	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. . 2018; 163 - 166.
IEEE	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M "MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome." , ss.163 - 166, 2018.
ISNAD	Karaca, Emin vd. "MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome". (2018), 163-166.

APA	Karaca E, aykut a, ERTÜRK B, DURMAZ M, Güler A, BÜKE B, Yeniel A, ERGENOĞLU A, ÖZKINAY F, OZEREN M, Kazandı M, Akercan F, Sağol S, Gunduz C, ÇOĞULU M (2018). MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. Balkan Medical Journal, 35(2), 163 - 166.
Chicago	Karaca Emin,aykut ayca,ERTÜRK Biray,DURMAZ MEHMET BURAK,Güler Ahmet,BÜKE Barış,Yeniel Ahmet Ozgur,ERGENOĞLU Ahmet Mete,ÖZKINAY FERİŞTAH FERDA,OZEREN MEHMET,Kazandı Mert,Akercan Fuat,Sağol Sermet,Gunduz Cumhur,ÇOĞULU MUHSİN ÖZGÜR MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. Balkan Medical Journal 35, no.2 (2018): 163 - 166.
MLA	Karaca Emin,aykut ayca,ERTÜRK Biray,DURMAZ MEHMET BURAK,Güler Ahmet,BÜKE Barış,Yeniel Ahmet Ozgur,ERGENOĞLU Ahmet Mete,ÖZKINAY FERİŞTAH FERDA,OZEREN MEHMET,Kazandı Mert,Akercan Fuat,Sağol Sermet,Gunduz Cumhur,ÇOĞULU MUHSİN ÖZGÜR MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. Balkan Medical Journal, vol.35, no.2, 2018, ss.163 - 166.
AMA	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. Balkan Medical Journal. 2018; 35(2): 163 - 166.
Vancouver	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome. Balkan Medical Journal. 2018; 35(2): 163 - 166.
IEEE	Karaca E,aykut a,ERTÜRK B,DURMAZ M,Güler A,BÜKE B,Yeniel A,ERGENOĞLU A,ÖZKINAY F,OZEREN M,Kazandı M,Akercan F,Sağol S,Gunduz C,ÇOĞULU M "MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome." Balkan Medical Journal, 35, ss.163 - 166, 2018.
ISNAD	Karaca, Emin vd. "MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome". Balkan Medical Journal 35/2 (2018), 163-166.