Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu

Oguzkan Balci, Sibel; ÇELENK, Fatih; DURUCU, Cengiz; DENİZ, Murat; TUNÇ, Orhan; Kanlikama, Muzaffer; MUMBUÇ, LÜTFİ SEMİH; BAYSAL, Elif; KAHRAMAN, Merve; pehlivan, sacide

Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu

Elif BAYSAL, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Sibel Oğuzkan BALCI, (Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Fatih ÇELENK, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Merve KAHRAMAN, (Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Murat DENİZ, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Orhan TUNÇ, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Cengiz DURUCU, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

LÜTFİ SEMİH MUMBUÇ, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Muzaffer KANLIKAMA, (Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey)

Sacide PEHLİVAN (Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey)

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Yıl: 2016 Cilt: 6 Sayı: 1 Sayfa Aralığı: 1 - 4 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu

Öz:

Amaç: Çalıflmamızda polimorfizmler, üç adet sitokin geni ekspresyonu ve konjenital sensorinöral iflitme kaybı tedavisi için koklear implantasyon uygulanmıfl çocukların klinik parametreleri arasındaki iliflkiyi inceledik. Yöntem:IL-6/-174, IFN-?/+874 ve TNF-?/-308 genleri, 64 konjenital sensorinöral iflitme kaybı hastasında ve 70 sağlıklı kontrol olgusunda analiz edildi. Sitokin ekspresyonu PCR-SSP yöntemi ile gerçeklefltirilmifltir. Bulgular:Hasta grubu ve sağlıklı kontrol grubu arasında TNF-? veya IL-6'nın genotipleri ve allel frekansları sayısı ve dağılımı bakımından belirgin bir farklılık saptanmadı. Ancak yüksek IFN-? ekspresyonu ile iliflkilendirilen TT genotipi ve T allel frekansı, hasta grubunda kontrol grubuna göre daha sıklıkla gözlendi (sırasıyla p=0.016 vep=0.023). Sonuç:Sonuçlarımız yüksek oranda IFN-? geni ekspresyonunun hastalığa olan duyarlılığı arttırdığını göstermifltir. Bunu takiben IFN-?geninin konjenital iflitme kaybının etyopatogenezinde yararlı bir belirteç olabileceği sonucu ortaya çıkmıfltır.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Hematoloji Hücre Biyolojisi Pediatri

Cytokine gene polymorphisms and expression in Turkish pediatric cochlear implant patients

Öz:

Objective:We assessed the association between the polymorphismsand expressions of three cytokine genes and clinical parameters inchildren who underwent cochlear implantation due to profound congenital sensorineural hearing loss. Methods:We analyzed the IL-6/-174, IFN-?/+874 and TNF-?/308 genes in 64 cases with congenital sensorineural hearing loss andin 70 healthy controls. Cytokine genotyping/expression was performed using the PCR-SSP method. Results: No significant differences were detected between the patientgroup and the healthy controls with respect to the distributions andnumbers of genotypes and alleles of TNF-? or IL-6. However, theTT genotype, associated with high expression of IFN-?, and the Tallele frequency were significantly more frequent in the patient groupversus the controls (p=0.016 and 0.023, respectively). Conclusion:Our results suggest that high expression of the IFN-?gene may be associated with susceptibility to the disease.Consequently, IFN-? may be a useful marker of the etiopathogenesisof congenital sensorineural hearing loss.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Hematoloji Hücre Biyolojisi Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYSAL E, Oguzkan Balci S, ÇELENK F, KAHRAMAN M, DENİZ M, TUNÇ O, DURUCU C, MUMBUÇ L, Kanlikama M, pehlivan s (2016). Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. , 1 - 4.
Chicago	BAYSAL Elif,Oguzkan Balci Sibel,ÇELENK Fatih,KAHRAMAN Merve,DENİZ Murat,TUNÇ Orhan,DURUCU Cengiz,MUMBUÇ LÜTFİ SEMİH,Kanlikama Muzaffer,pehlivan sacide Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. (2016): 1 - 4.
MLA	BAYSAL Elif,Oguzkan Balci Sibel,ÇELENK Fatih,KAHRAMAN Merve,DENİZ Murat,TUNÇ Orhan,DURUCU Cengiz,MUMBUÇ LÜTFİ SEMİH,Kanlikama Muzaffer,pehlivan sacide Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. , 2016, ss.1 - 4.
AMA	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. . 2016; 1 - 4.
Vancouver	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. . 2016; 1 - 4.
IEEE	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s "Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu." , ss.1 - 4, 2016.
ISNAD	BAYSAL, Elif vd. "Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu". (2016), 1-4.

APA	BAYSAL E, Oguzkan Balci S, ÇELENK F, KAHRAMAN M, DENİZ M, TUNÇ O, DURUCU C, MUMBUÇ L, Kanlikama M, pehlivan s (2016). Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. ENT Updates, 6(1), 1 - 4.
Chicago	BAYSAL Elif,Oguzkan Balci Sibel,ÇELENK Fatih,KAHRAMAN Merve,DENİZ Murat,TUNÇ Orhan,DURUCU Cengiz,MUMBUÇ LÜTFİ SEMİH,Kanlikama Muzaffer,pehlivan sacide Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. ENT Updates 6, no.1 (2016): 1 - 4.
MLA	BAYSAL Elif,Oguzkan Balci Sibel,ÇELENK Fatih,KAHRAMAN Merve,DENİZ Murat,TUNÇ Orhan,DURUCU Cengiz,MUMBUÇ LÜTFİ SEMİH,Kanlikama Muzaffer,pehlivan sacide Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. ENT Updates, vol.6, no.1, 2016, ss.1 - 4.
AMA	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. ENT Updates. 2016; 6(1): 1 - 4.
Vancouver	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu. ENT Updates. 2016; 6(1): 1 - 4.
IEEE	BAYSAL E,Oguzkan Balci S,ÇELENK F,KAHRAMAN M,DENİZ M,TUNÇ O,DURUCU C,MUMBUÇ L,Kanlikama M,pehlivan s "Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu." ENT Updates, 6, ss.1 - 4, 2016.
ISNAD	BAYSAL, Elif vd. "Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalar>ndaki ekspresyonu". ENT Updates 6/1 (2016), 1-4.