EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA

BAYAMLIOĞLU, Hande; GÖNENÇ, Aymelek; DURU, Erdal; BIYIKOĞLU, Funda

EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA

Hande BAYAMLIOĞLU, (Gazi University)

Aymelek GÖNENÇ, (Gazi University)

Erdal DURU, (Türkiye Yüksek İhtisas Education and Research Hospital)

Funda BIYIKOĞLU (Türkiye Yüksek İhtisas Education and Research Hospital)

Turkish Journal of Pharmaceutical Sciences

1 0

Yıl: 2012 Cilt: 9 Sayı: 3 Sayfa Aralığı: 359 - 370 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA

Öz:

Bu çalışmada hmerlıpıdemık hastalarda adıponektııı, protein karbonilasyonu, TAK, NF-a ve IL-6 düzeyleri ölçülerek saglıklı grup ile karşılaştırılmıştır. Adiponektin, TNF--a and lL-6 düzeyleri ELISA metodu ile analiz edilmiştir. TAK ve protein karbonilasyonu, düzeyleri spektrofotometrık olarak ölçülmüştür. Saglıklı kontroller ile karşılaştırıldıgında total hasta grubunda adhvonektin ve TAK düzeylerinde anlamlı farklılıklar bulunmuştur (p<0. 05, p<0.01). Total hastalar üç gruba ayrılmıştır: hıperlıpidemik, hıperlıpidemık ve koroner arter stenoz/u ve koroner arter stenozlu. Adıponektin düzeyleri kontrol grubu ile karşılaştırıldıgında hıperlıpidemili ve koroner arter stenozu olan grupta yüksekti (p<0. 0]). Protein karbonilasyonu hıperlıpidemili grupta kontrol grubundan daha yüksekti (p<0. 01). TAK düzeyleri kontrol grubu ile karşılaştırıldıgında hem hıperlıpıdemili grupta hem de hıperlıpidemili ve koroner arter stenozu olan grupta azalmıştı (p<0. 05, p<0. 01). Protein karbonilasyonu hıperlıpıdemili hastalarda hıperlıpıdemili ve koroner arter stenozu olan hastalardan daha yüksekti (p<0. 01). Sonuç olarak, çalışmamız hıperlipidemide oksidatif stresin arttıgını göstennektedir. Hiperlipidemi ile birlıkte koroner arter stenozunda adıponektın düzeylerinin kalbi oksidatifhasardan korumak için artmış olabilecegıni söyleyebiliriz.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Hiperlipidemide Serum Adiponektin Diizeyleri ile Oksidatif Stres, Proinflamatuvar Sitokinler Arasındaki İlişkinin Değerlendirilmesi

Öz:

Bu çalışmada hmerlıpıdemık hastalarda adıponektııı, protein karbonilasyonu, TAK, NF-a ve IL-6 düzeyleri ölçülerek saglıklı grup ile karşılaştırılmıştır. Adiponektin, TNF—a and lL-6 düzeyleri ELISA metodu ile analiz edilmiştir. TAK ve protein karbonilasyonu, düzeyleri spektrofotometrık olarak ölçülmüştür. Saglıklı kontroller ile karşılaştırıldıgında total hasta grubunda adhvonektin ve TAK düzeylerinde anlamlı farklılıklar bulunmuştur (p<0. 05, p<0.01). Total hastalar üç gruba ayrılmıştır: hıperlıpidemik, hıperlıpidemık ve koroner arter stenoz/u ve koroner arter stenozlu. Adıponektin düzeyleri kontrol grubu ile karşılaştırıldıgında hıperlıpidemili ve koroner arter stenozu olan grupta yüksekti (p<0. 0]). Protein karbonilasyonu hıperlıpidemili grupta kontrol grubundan daha yüksekti (p<0. 01). TAK düzeyleri kontrol grubu ile karşılaştırıldıgında hem hıperlıpıdemili grupta hem de hıperlıpidemili ve koroner arter stenozu olan grupta azalmıştı (p<0. 05, p<0. 01). Protein karbonilasyonu hıperlıpıdemili hastalarda hıperlıpıdemili ve koroner arter stenozu olan hastalardan daha yüksekti (p<0. 01). Sonuç olarak, çalışmamız hıperlipidemide oksidatif stresin arttıgını göstennektedir. Hiperlipidemi ile birlıkte koroner arter stenozunda adıponektın düzeylerinin kalbi oksidatifhasardan korumak için artmış olabilecegıni söyleyebiliriz.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYAMLIOĞLU H, GÖNENÇ A, DURU E, BIYIKOĞLU F (2012). EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. , 359 - 370.
Chicago	BAYAMLIOĞLU Hande,GÖNENÇ Aymelek,DURU Erdal,BIYIKOĞLU Funda EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. (2012): 359 - 370.
MLA	BAYAMLIOĞLU Hande,GÖNENÇ Aymelek,DURU Erdal,BIYIKOĞLU Funda EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. , 2012, ss.359 - 370.
AMA	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. . 2012; 359 - 370.
Vancouver	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. . 2012; 359 - 370.
IEEE	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F "EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA." , ss.359 - 370, 2012.
ISNAD	BAYAMLIOĞLU, Hande vd. "EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA". (2012), 359-370.

APA	BAYAMLIOĞLU H, GÖNENÇ A, DURU E, BIYIKOĞLU F (2012). EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. Turkish Journal of Pharmaceutical Sciences, 9(3), 359 - 370.
Chicago	BAYAMLIOĞLU Hande,GÖNENÇ Aymelek,DURU Erdal,BIYIKOĞLU Funda EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. Turkish Journal of Pharmaceutical Sciences 9, no.3 (2012): 359 - 370.
MLA	BAYAMLIOĞLU Hande,GÖNENÇ Aymelek,DURU Erdal,BIYIKOĞLU Funda EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. Turkish Journal of Pharmaceutical Sciences, vol.9, no.3, 2012, ss.359 - 370.
AMA	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. Turkish Journal of Pharmaceutical Sciences. 2012; 9(3): 359 - 370.
Vancouver	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA. Turkish Journal of Pharmaceutical Sciences. 2012; 9(3): 359 - 370.
IEEE	BAYAMLIOĞLU H,GÖNENÇ A,DURU E,BIYIKOĞLU F "EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA." Turkish Journal of Pharmaceutical Sciences, 9, ss.359 - 370, 2012.
ISNAD	BAYAMLIOĞLU, Hande vd. "EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS, PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA". Turkish Journal of Pharmaceutical Sciences 9/3 (2012), 359-370.