The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats

KARAMAN, Abdurrahman; KÖROĞLU, Reyhan; BATİ, Fatih; KOKSAL, Ismail; KEKİLLİ, Ersoy; POLAT, Alaattin

The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats

Ismail KOKSAL, (Inonu University, Faculty of Medicine, Department of Nuclear Medicine, Malatya, Turkey)

Ersoy KEKİLLİ, (Inonu University, Faculty of Medicine, Department of Nuclear Medicine, Malatya, Turkey)

Reyhan KÖROĞLU, (Inonu University, Faculty of Medicine, Department of Nuclear Medicine, Malatya, Turkey)

Fatih BATİ, (Inonu University, Faculty of Medicine, Department of Nuclear Medicine, Malatya, Turkey)

Abdurrahman KARAMAN, (Inonu University, Faculty of Medicine, Department of Pediatric Surgery, Malatya, Turkey)

Alaattin POLAT (Inonu University, Faculty of Medicine, Physiology, Malatya, Turkey)

Medicine Science

3 0

Yıl: 2016 Cilt: 5 Sayı: 1 Sayfa Aralığı: 134 - 146 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats

Öz:

Cholestatic diseases in neonates which characterized by deterioration of bile passage to intestine. We investigated the usability of Tc-99m MIBI as a hepatobiliary scintigraphy radiopharmaceutical for diferential diagnosis of biliary atresia and hepatitis in experimental model. A total of 20 males Wistar albino rats who had weights ranging from 200-350 g were included in this study. Rats were randomly divided into 4 groups. Control group, sham operated group, biliary atresia group and chemical hepatitis group (with carbon tetrachloride) were created, respectively. Blood flow phases, consantration and early excreation phases was performed after an intravenous injection through the internal jugular vein of 37 MBq Tc-99m MIBI using a gamma camera. Dual late static images were obtained at the same position at 15, 30, 60, 90 and 120 min after injection. In control group, radiopharmaceutical passage into the small intestine was seen between 45 and 60 min and evidently seen between 120 and 150 min as large hyperactive focus on midline or non-linear (snaky) radiopharmaceutical accumulation at the level of kidney. In biliary atresia group, radiopharmaceutical concentration was seen normal in liver but passage into the small intestine was not seen all rats. In carbon tetrachloride group, blood flow, concentration and early excretion scintigraphic images did not differ from control group and radiopharmaceutical passage into the small intestine was seen between 45 and 60 min. Although radiopharmaceuticals passage into the intestine was not shown in all rats of biliary atresia group. We suggest that Tc-99m MIBI as a radiopharmaceutical of hepatobiliary scintigraphy would be the contribution of the differential diagnosis of biliary atresia and hepatitis in humans

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KOKSAL I, KEKİLLİ E, KÖROĞLU R, BATİ F, KARAMAN A, POLAT A (2016). The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. , 134 - 146.
Chicago	KOKSAL Ismail,KEKİLLİ Ersoy,KÖROĞLU Reyhan,BATİ Fatih,KARAMAN Abdurrahman,POLAT Alaattin The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. (2016): 134 - 146.
MLA	KOKSAL Ismail,KEKİLLİ Ersoy,KÖROĞLU Reyhan,BATİ Fatih,KARAMAN Abdurrahman,POLAT Alaattin The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. , 2016, ss.134 - 146.
AMA	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. . 2016; 134 - 146.
Vancouver	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. . 2016; 134 - 146.
IEEE	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A "The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats." , ss.134 - 146, 2016.
ISNAD	KOKSAL, Ismail vd. "The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats". (2016), 134-146.

APA	KOKSAL I, KEKİLLİ E, KÖROĞLU R, BATİ F, KARAMAN A, POLAT A (2016). The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. Medicine Science, 5(1), 134 - 146.
Chicago	KOKSAL Ismail,KEKİLLİ Ersoy,KÖROĞLU Reyhan,BATİ Fatih,KARAMAN Abdurrahman,POLAT Alaattin The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. Medicine Science 5, no.1 (2016): 134 - 146.
MLA	KOKSAL Ismail,KEKİLLİ Ersoy,KÖROĞLU Reyhan,BATİ Fatih,KARAMAN Abdurrahman,POLAT Alaattin The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. Medicine Science, vol.5, no.1, 2016, ss.134 - 146.
AMA	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. Medicine Science. 2016; 5(1): 134 - 146.
Vancouver	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats. Medicine Science. 2016; 5(1): 134 - 146.
IEEE	KOKSAL I,KEKİLLİ E,KÖROĞLU R,BATİ F,KARAMAN A,POLAT A "The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats." Medicine Science, 5, ss.134 - 146, 2016.
ISNAD	KOKSAL, Ismail vd. "The Value of Tc-99m Mibi for Differential Diagnosis of Biliary Atresia and Hepatitis in Rats". Medicine Science 5/1 (2016), 134-146.