Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns

KÖKTÜRK, Fürüzan; Şen Tanrıkulu, Ceren; TANRIKULU, Yusuf; Bahadir, Burak; CAN, Murat; KILINÇ, FAHRİYE

Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns

Ceren Şen TANRIKULU, (Department of Emergency Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey)

Yusuf TANRIKULU, (Department of Emergency Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey)

Fahriye KILINÇ, (Department of General Surgery, Zonguldak Atatürk State Hospital, Zonguldak-Turkey)

Burak BAHADIR, (Department of Pathology, Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey)

Murat CAN, (Department of Biochemistry, Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey)

Fürüzan KÖKTÜRK (Department of Biostatistics, Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey)

Ulusal Travma ve Acil Cerrahi Dergisi

7 0

Yıl: 2017 Cilt: 23 Sayı: 3 Sayfa Aralığı: 181 - 187 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns

Öz:

BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn.METHODS: Twenty-eight rats were randomly divided into 4 equal groups: group 1 (sham), group 2 (control), group 3 (topical treatment), and group 4 (topical and systemic treatment). In groups 2, 3, and 4, corrosive esophageal burns were generated by applying sodium hydroxide to a 1.5-cm segment of the abdominal esophagus. Normal saline was applied to group 2, topical garlic oil to group 3, and topical and systemic garlic oil were used in group 4.RESULTS: The level of hydroxyproline was lower in the topical treatment groups than in the control group (p=0.023). There was difference in tumor necrosis factor alpha level between the systemic treatment groups and the control group (p=0.044). Treatment with garlic oil decreased stenosis index (SI) and histopathological damage score (HDS) in corrosive esophageal burn rats. The SI in the topical treatment group was significantly lower than that of the control group (p=0.016). The HDS was significantly lower in group 4 when compared with the control group (p=0.019).CONCLUSION: Garlic oil is an effective agent in promoting the regression of esophageal stenosis and tissue damage caused by corrosive burns. While the protective effect of garlic oil on tissue damage is more significant when applied topically, the anti-inflammatory effect is more pronounced when applied systemically. Therefore, we believe that the application of garlic oil in patients with corrosive esophageal burns can reduce complication rates

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APA	Şen Tanrıkulu C, TANRIKULU Y, KILINÇ F, Bahadir B, CAN M, KÖKTÜRK F (2017). Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. , 181 - 187.
Chicago	Şen Tanrıkulu Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. (2017): 181 - 187.
MLA	Şen Tanrıkulu Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. , 2017, ss.181 - 187.
AMA	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. . 2017; 181 - 187.
Vancouver	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. . 2017; 181 - 187.
IEEE	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F "Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns." , ss.181 - 187, 2017.
ISNAD	Şen Tanrıkulu, Ceren vd. "Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns". (2017), 181-187.

APA	Şen Tanrıkulu C, TANRIKULU Y, KILINÇ F, Bahadir B, CAN M, KÖKTÜRK F (2017). Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulusal Travma ve Acil Cerrahi Dergisi, 23(3), 181 - 187.
Chicago	Şen Tanrıkulu Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulusal Travma ve Acil Cerrahi Dergisi 23, no.3 (2017): 181 - 187.
MLA	Şen Tanrıkulu Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulusal Travma ve Acil Cerrahi Dergisi, vol.23, no.3, 2017, ss.181 - 187.
AMA	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulusal Travma ve Acil Cerrahi Dergisi. 2017; 23(3): 181 - 187.
Vancouver	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulusal Travma ve Acil Cerrahi Dergisi. 2017; 23(3): 181 - 187.
IEEE	Şen Tanrıkulu C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F "Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns." Ulusal Travma ve Acil Cerrahi Dergisi, 23, ss.181 - 187, 2017.
ISNAD	Şen Tanrıkulu, Ceren vd. "Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns". Ulusal Travma ve Acil Cerrahi Dergisi 23/3 (2017), 181-187.