Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis

SAKİN, Önder; YILMAZ, Aylin Onan; ESİM BÜYÜKBAYRAK, ESRA; ÖZKAN, Sadullah; BEKTAŞ, Yaren Tuba; BAŞAK, Kayhan; Şimşek, Engin Ersin; PİRİMOĞLU, Zehra Meltem

Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis

Yaren Tuba BEKTAŞ, (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Önder SAKİN, (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Zehra Meltem PİRİMOĞLU, (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Aylin Onan YILMAZ, (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Kayhan BAŞAK, (Department of Pathology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Esra Esim BÜYÜKBAYRAK, (Department of Pathology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Sadullah ÖZKAN, (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Engin Ersin ŞİMŞEK (Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey)

Southern Clinics of Istanbul Eurasia

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Yıl: 2017 Cilt: 28 Sayı: 4 Sayfa Aralığı: 261 - 265 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis

Öz:

Objective: The aim of the present study was to determine the density of nerve fibers in the functional layer of the endometrium in patients with endometriosis in order to determine if it could be used as a minimally invasive diagnostic method for endometriosis. A secondary goal was to assess the relationship between the severity of pelvic pain due to endometriosis and the density of nerve fibers in endometrial sampling materials.Methods: Endometrial sampling was performed in 67 patients who presented at the hospital between August 2011 and November 2012. Endometriosis was diagnosed by surgical histopathological examination. A total of 34 patients diagnosed with endometriosis were selected as the study group. Thirty-three patients who were operated on for benign conditions other than endometriosis were selected as a control group. Immunohistochemical detection of the nerve fiber marker protein gene product 9.5 (PGP 9.5) was used to analyze the endometrial samples for nerve fibers. Visual Analogue Scale scores were used to evaluate the correlation between nerve fiber density and the severity of pelvic pain. Statistical analyses were calculated with SPSS Statistics for Windows, Version 17.0 (SPSS, Inc., Chicago, IL, USA).Results: The mean density of nerve fibers was 1.85±1.74 fibers/mm2 in the endometriosis group. In the control group, the mean density was 1.15±1.48 fibers/mm2. There was no statistically significant difference between the groups (p=0.08). The pelvic pain score did not correlate with PGP 9.5 intensity.Conclusion: The detection and measurement of nerve fibers in the eutopic endometrium using the PGP 9.5 marker was not found to be a decisive noninvasive method to diagnose endometriosis

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BEKTAŞ Y, SAKİN Ö, PİRİMOĞLU Z, YILMAZ A, BAŞAK K, ESİM BÜYÜKBAYRAK E, ÖZKAN S, Şimşek E (2017). Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. , 261 - 265.
Chicago	BEKTAŞ Yaren Tuba,SAKİN Önder,PİRİMOĞLU Zehra Meltem,YILMAZ Aylin Onan,BAŞAK Kayhan,ESİM BÜYÜKBAYRAK ESRA,ÖZKAN Sadullah,Şimşek Engin Ersin Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. (2017): 261 - 265.
MLA	BEKTAŞ Yaren Tuba,SAKİN Önder,PİRİMOĞLU Zehra Meltem,YILMAZ Aylin Onan,BAŞAK Kayhan,ESİM BÜYÜKBAYRAK ESRA,ÖZKAN Sadullah,Şimşek Engin Ersin Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. , 2017, ss.261 - 265.
AMA	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. . 2017; 261 - 265.
Vancouver	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. . 2017; 261 - 265.
IEEE	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E "Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis." , ss.261 - 265, 2017.
ISNAD	BEKTAŞ, Yaren Tuba vd. "Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis". (2017), 261-265.

APA	BEKTAŞ Y, SAKİN Ö, PİRİMOĞLU Z, YILMAZ A, BAŞAK K, ESİM BÜYÜKBAYRAK E, ÖZKAN S, Şimşek E (2017). Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. Southern Clinics of Istanbul Eurasia, 28(4), 261 - 265.
Chicago	BEKTAŞ Yaren Tuba,SAKİN Önder,PİRİMOĞLU Zehra Meltem,YILMAZ Aylin Onan,BAŞAK Kayhan,ESİM BÜYÜKBAYRAK ESRA,ÖZKAN Sadullah,Şimşek Engin Ersin Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. Southern Clinics of Istanbul Eurasia 28, no.4 (2017): 261 - 265.
MLA	BEKTAŞ Yaren Tuba,SAKİN Önder,PİRİMOĞLU Zehra Meltem,YILMAZ Aylin Onan,BAŞAK Kayhan,ESİM BÜYÜKBAYRAK ESRA,ÖZKAN Sadullah,Şimşek Engin Ersin Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. Southern Clinics of Istanbul Eurasia, vol.28, no.4, 2017, ss.261 - 265.
AMA	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. Southern Clinics of Istanbul Eurasia. 2017; 28(4): 261 - 265.
Vancouver	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis. Southern Clinics of Istanbul Eurasia. 2017; 28(4): 261 - 265.
IEEE	BEKTAŞ Y,SAKİN Ö,PİRİMOĞLU Z,YILMAZ A,BAŞAK K,ESİM BÜYÜKBAYRAK E,ÖZKAN S,Şimşek E "Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis." Southern Clinics of Istanbul Eurasia, 28, ss.261 - 265, 2017.
ISNAD	BEKTAŞ, Yaren Tuba vd. "Diagnostic Value of Endometrial Nerve Endometrial Tissue of Patients with Endometriosis". Southern Clinics of Istanbul Eurasia 28/4 (2017), 261-265.