This study was performed to evaluate the effect of weekly intravaneous administration of Novacoc®, 3 weeks before parturition on some hematological, metabolism, and immune parameters on early lactation period in dairy cows. In this study 20 random Holstein dairy cows has been used and divided into two groups as control group and the treatment group. The treatment started 3 weeks before parturation and ended parturaiton. The treatment has been made in first three days of each week. The animals in the treatment group were administered daily Novacoc®, 200 ml (Metamizol Sodium; 40 mg, Acetyl methionine 40 mg, Caffeine 3,5 mg, Calcium Gluconate 100 mg, Magnesium Gluconate 10 mg, Sodium Dihydrogen Phospate Dhydrate 4,02 mg, Glucose monohydrate 200; İnterhas®, Türkiye) as intravenous slowly infusion on first 3 days of each weeks during last 3 weeks of prepartum period and first 3 weeks of postpartum period. Parturition day was planned as day “0 (zero)”; blood samples were collected on days -21, -14, -7, 0, 7, 14, 21 from V. Coccygea of all cows. Total cholesterol, HDL, triglyceride, and glucose levels were significantly higher on some postpartum days; However, NEFA and BHBA levels were found decreased. NEFA and BHBA levels in the control group were detected as subclinical ketosis levels. In addition to this results, the milk yields of each group were measured as same during first 3 weeks of lactation, but peak milk yield on the treatment group increased significantly