Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients

Celebi, Solmaz; Ozer, Arife; HACIMUSTAFAOĞLU, Mustafa Kemal; Sigirli, Deniz; ELMAS BOZDEMIR, SEFİKA; SALI, Enes; ÖZCAN, İsmail; Çakır, Deniz

Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients

Şefika Elmas BOZDEMİR, (Clinic of Pediatrics, Bursa Dortcelik Pediatric Hospital, Bursa, Turkey)

Solmaz ÇELEBİ, (Department of Pediatric Infectious Diseases, Uludag University School of Medicine, Bursa, Turkey)

Deniz ÇAKIR, (Clinic of Pediatric Infection, Umraniye Training and Research Hospital, İstanbul, Turkey)

İsmail ÖZCAN, (Clinic of Pediatrics, Bursa Dortcelik Pediatric Hospital, Bursa, Turkey)

Deniz SIĞIRLI, (Department of Biostatistic, Uludag University, School of Medicine, Bursa, Turkey)

Enes SALI, (Clinic of Pediatric Infectious Diseases, Sanliurfa Training and Research Hospital, Şanlıurfa, Turkey)

Arife ÖZER, (Department of Pediatric Infectious Diseases, Uludag University School of Medicine, Bursa, Turkey)

Mustafa Kemal HACIMUSTAFAOĞLU (Department of Pediatric Infectious Diseases, Uludag University School of Medicine, Bursa, Turkey 3)

Çocuk Enfeksiyon Dergisi

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Yıl: 2016 Cilt: 10 Sayı: 4 Sayfa Aralığı: 128 - 136 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients

Öz:

Amaç: Çok merkezli bu çalışmada, bir yıllık sürede 3 büyük çocuk hastanesinde 0-2 yaş arası Respiratuvar Sinsityal Virüs (RSV) saptanan alt solunum yolu enfeksiyonu (ASYE) nedeniyle hastaneye yatırılan olgularda direkt tıbbi maliyet değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Bir yıl süresince 3 farklı çocuk hastanesinde <2 yaş ASYE ile yatan RSV+ ve RSVolgular çalışmaya alındı. RSV tanısı nazofarengiyal antijen tespiti ile konuldu. Direkt tıbbi maliyetler (yatış, laboratuvar, tedavi maliyetleri) hastane faturalarından çıkarıldı. Antibiyotik verilen olguların antibiyotik maliyetleri ayrıca hesaplandı. Çalışmada indirekt maliyetler dikkate alınmadı ve değerlendirilmedi. Bulgular: Çalışmada toplam yatan <2 yaş olguların %10'u ASYE ile yattı. Yatan ASYE'lerin %38'i (254/671) akut bronşiyolitlerin %41 (151/368), pnömonilerin %34 (103/303) RSV pozitifti. Tüm yatan olguların %4'ü RSV+ASYE idi RSV+ASYE'lerin yaklaşık %88'i RSV-ASYE'lerin %92'si antibiyotik almıştı (p=0,09). RSV+ASYE'lerin %10'u, RSV-ASYE'lerin %13'ü yoğun bakıma yatırıldı (p=0,19). Antibiyotik dahil toplam direkt tıbbi yatış maliyetleri RSV+ASYE'de kişi başı medyan değeri 334 (ortalama+ SD: 910±226) $, olgu başına antibiyotik maliyeti medyan değeri 24 (103±548) $, olgu başına antibiyotik dışı maliyet medyan değeri 301 (789±1826) $ saptandı. RSV-ASYE'de ise bu değerler sırasıyla 358 (1028±2741) $, 33 (90±236) $, 320 (911±2625) $ bulundu. RSV+ASYE olgularının %48'i 0-3 ay arasındaydı ve bu yaş grubunda olgu başına maliyet ortalaması 4-6 ay ve 7-11 ay yaş gruplarına göre 2 kattan daha fazla bulundu (sırasıyla ortalama 1068, 508 ve 352$). Toplam 254 RSV+ olgunun yatış maliyeti 231.178$, RSV417 olgunun maliyeti ise 428,991 $ bulundu. Sonuç: Bu sonuçlara göre RSV enfeksiyonları halen <2 yaşta ASYE'lerin önemli bir kısmını oluşturmakta ve önemli bir epidemiyolojik ve ekonomik hastalık yüküne neden olmaktadır

Anahtar Kelime:

Konular: Genel ve Dahili Tıp Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji

<2 Yaş RSV+ ASYE Yatan Hastalarda Direkt Tıbbi Maliyet Değerlendirmesi

Öz:

Objective: This multi-center study aimed to assessthe direct medical costs in patients aged between 0-2year-old admitted to the hospital due to lower respiratorytract infection (LRTI), which was identified asrespiratory syncytial virus (RSV) in 3 big pediatrichospitals for a year.Material and Methods: During one-year period,<2-year-old LRTI patients with RSV+ and RSVwereincluded in the study conducted in 3 different pediatrichospitals. RSV was diagnosed with the detection ofnasopharyngeal antigen. Direct medical costs (hospitalization,laboratory and treatment costs) wereremoved from the hospitals bills. Antibiotic costs of theantibiotic-treated cases were calculated independently.The indirect costs in the study were not consideredand evaluated.Results: In the study, 10% of the total inpatients aged<2-years were hospitalized with LRTI. 38% (254/671)of patients with LRTI, 41% (151/368) of those withacute bronchiolitis and 34% (103/303) of those withpneumonia were RSV positive. 4% of all hospitalizedcases were RSV+LRTI; nearly 88% of the RSV+LRTIsand 92% of RSVLRTIsreceived antibiotics (p=0.09).10% of the RSV+LRTIs and 13% of RSVRLTIswerehospitalized in the intensive care units (p=0.19). It wasfound that the total direct medical hospitalization costsincluding the antibiotics including the RSV+LRTI medianvalues were 334 (range: 6-21545) (mean+SD:910±226) $, antibiotic costs median value was 24(0-7691) (103±548) $, and non-antibiotic medianvalue was 301 (6-18767) (789±1826) $. It was foundthat these values in the RSVLRTI,on the other hand,358 (5-31938) (1028±2741) $, 33 (0-33333) (90±236)$, 320 (5-31767) (911±2625) $ respectively. 48% of RSV+LRTIcases were aged between 0-3 months and it was found that theaverage cost per case was in this age group was two timeshigher than the 4-6 months and 7-11 months age group (onaverage 1068, 508 and 352$ respectively). It was found that thehospitalization costs of the total of 254 RSV+ patients were $231,178 and the costs of the 417 RSVpatients were $ 428,991.Conclusion: According to these results, RSV infections stillconstitute a significant part of RLTIs at <2 years of age in ourcountry and cause an important epidemiological and economicdisease burden. (J Pediatr Inf 2016; 10: 128-36)

Anahtar Kelime:

Konular: Genel ve Dahili Tıp Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ELMAS BOZDEMIR S, Celebi S, Çakır D, ÖZCAN İ, Sigirli D, SALI E, Ozer A, HACIMUSTAFAOĞLU M (2016). Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. , 128 - 136.
Chicago	ELMAS BOZDEMIR SEFİKA,Celebi Solmaz,Çakır Deniz,ÖZCAN İsmail,Sigirli Deniz,SALI Enes,Ozer Arife,HACIMUSTAFAOĞLU Mustafa Kemal Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. (2016): 128 - 136.
MLA	ELMAS BOZDEMIR SEFİKA,Celebi Solmaz,Çakır Deniz,ÖZCAN İsmail,Sigirli Deniz,SALI Enes,Ozer Arife,HACIMUSTAFAOĞLU Mustafa Kemal Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. , 2016, ss.128 - 136.
AMA	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. . 2016; 128 - 136.
Vancouver	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. . 2016; 128 - 136.
IEEE	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M "Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients." , ss.128 - 136, 2016.
ISNAD	ELMAS BOZDEMIR, SEFİKA vd. "Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients". (2016), 128-136.

APA	ELMAS BOZDEMIR S, Celebi S, Çakır D, ÖZCAN İ, Sigirli D, SALI E, Ozer A, HACIMUSTAFAOĞLU M (2016). Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. Çocuk Enfeksiyon Dergisi, 10(4), 128 - 136.
Chicago	ELMAS BOZDEMIR SEFİKA,Celebi Solmaz,Çakır Deniz,ÖZCAN İsmail,Sigirli Deniz,SALI Enes,Ozer Arife,HACIMUSTAFAOĞLU Mustafa Kemal Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. Çocuk Enfeksiyon Dergisi 10, no.4 (2016): 128 - 136.
MLA	ELMAS BOZDEMIR SEFİKA,Celebi Solmaz,Çakır Deniz,ÖZCAN İsmail,Sigirli Deniz,SALI Enes,Ozer Arife,HACIMUSTAFAOĞLU Mustafa Kemal Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. Çocuk Enfeksiyon Dergisi, vol.10, no.4, 2016, ss.128 - 136.
AMA	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. Çocuk Enfeksiyon Dergisi. 2016; 10(4): 128 - 136.
Vancouver	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients. Çocuk Enfeksiyon Dergisi. 2016; 10(4): 128 - 136.
IEEE	ELMAS BOZDEMIR S,Celebi S,Çakır D,ÖZCAN İ,Sigirli D,SALI E,Ozer A,HACIMUSTAFAOĞLU M "Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients." Çocuk Enfeksiyon Dergisi, 10, ss.128 - 136, 2016.
ISNAD	ELMAS BOZDEMIR, SEFİKA vd. "Direct Medical Cost Assessment in the <2 Years- Old Hospitalized RSV+LRTI Patients". Çocuk Enfeksiyon Dergisi 10/4 (2016), 128-136.