Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study

LEVENT, Akın; AYDIN, Mehmet Dumlu; YOLAŞ, Coşkun; Aydin, Nazan; Gündoğdu, Cemal; Kanat, Ayhan; OZDEMIR, Nuriye Guzin

Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study

Ayhan KANAT, (Recep Tayyip Erdogan University, Faculty of Medicine, Department of Neurosurgery, Rize, Turkey)

Akın LEVENT, (Ataturk University, Faculty of Medicine, Department of Radiology, Erzurum, Turkey)

Coşkun YOLAŞ, (Erzurum Regional Training and Research Hospital, Neurosurgery Clinic, Erzurum, Turkey)

Mehmet Dumlu AYDIN, (Ataturk University, Faculty of Medicine, Department of Neurosurgery, Erzurum, Turkey)

Cemal GÜNDOĞDU, (Ataturk University, Faculty of Medicine, Department of Pathology, Erzurum, Turkey)

Nuriye Guzin OZDEMIR, (Istanbul Training and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey)

Nazan AYDIN (Bakırkoy Research and Training Hospital, Psychiatry Clinic, Istanbul, Turkey)

Turkish Neurosurgery

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Yıl: 2017 Cilt: 27 Sayı: 6 Sayfa Aralığı: 874 - 883 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study

Öz:

AIm: Cerebral vasospasm after subarachnoid hemorrhage (SAH) may lead to a devastating neurological outcome by inducing cerebral ischemia. However the role of external carotid artery (ECA) vasospasm has been rarely reported in the literature. The aim of this study was to elucidate the effect of ECA vasospasm on cerebral ischemia related neurodegeneration in the cerebral cortex after SAH. mATERIAl and mEThODS: This study was performed on 23 rabbits, divided into three groups: control (n=5), sham (n=5), and SAH (n=13). Experimental SAH was performed by injecting 0.75 mL auricular arterial homologous blood into the cisterna magna. After three weeks, the animals were decapitated and the common carotid arteries with their external and internal branches and the brains were examined histopathologically. Vasospasm indexes (VSI) of ECAs and internal carotid arteries (ICAs) and degenerated glial cell numbers of temporal cortices (n/mm3) were estimated stereologically and the results were compared statistically. RESUlTS: Temporal cortex glial cell density was estimated as 136.950±9.257/mm3 in normal rabbits, 131.324±7.987/mm3 in sham, 112.320±6.112/mm3 in light, and 97.543±5.432/mm3 in severe ECA vasospasm. The mean VSI values of ECA of all groups were 1.95±0.21, 2.15±0.29, 2.95±0.65 and 3.12±0.276, respectively. Statistical differences between the VSI values of ECA and degenerated neuron densities in temporal cortices were significant (p<0.005). CONClUSION: ECA vasospasm was observed to have a more important predictive role on the serious cerebral ischemia and neuronal degeneration after SAH. The mechanism may be related to ischemia of the parasympathetic ganglia of the lower cranial nerves and dorsal root ganglion

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Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kanat A, LEVENT A, YOLAŞ C, AYDIN M, Gündoğdu C, OZDEMIR N, Aydin N (2017). Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. , 874 - 883.
Chicago	Kanat Ayhan,LEVENT Akın,YOLAŞ Coşkun,AYDIN Mehmet Dumlu,Gündoğdu Cemal,OZDEMIR Nuriye Guzin,Aydin Nazan Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. (2017): 874 - 883.
MLA	Kanat Ayhan,LEVENT Akın,YOLAŞ Coşkun,AYDIN Mehmet Dumlu,Gündoğdu Cemal,OZDEMIR Nuriye Guzin,Aydin Nazan Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. , 2017, ss.874 - 883.
AMA	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. . 2017; 874 - 883.
Vancouver	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. . 2017; 874 - 883.
IEEE	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N "Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study." , ss.874 - 883, 2017.
ISNAD	Kanat, Ayhan vd. "Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study". (2017), 874-883.

APA	Kanat A, LEVENT A, YOLAŞ C, AYDIN M, Gündoğdu C, OZDEMIR N, Aydin N (2017). Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. Turkish Neurosurgery, 27(6), 874 - 883.
Chicago	Kanat Ayhan,LEVENT Akın,YOLAŞ Coşkun,AYDIN Mehmet Dumlu,Gündoğdu Cemal,OZDEMIR Nuriye Guzin,Aydin Nazan Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. Turkish Neurosurgery 27, no.6 (2017): 874 - 883.
MLA	Kanat Ayhan,LEVENT Akın,YOLAŞ Coşkun,AYDIN Mehmet Dumlu,Gündoğdu Cemal,OZDEMIR Nuriye Guzin,Aydin Nazan Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. Turkish Neurosurgery, vol.27, no.6, 2017, ss.874 - 883.
AMA	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. Turkish Neurosurgery. 2017; 27(6): 874 - 883.
Vancouver	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study. Turkish Neurosurgery. 2017; 27(6): 874 - 883.
IEEE	Kanat A,LEVENT A,YOLAŞ C,AYDIN M,Gündoğdu C,OZDEMIR N,Aydin N "Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study." Turkish Neurosurgery, 27, ss.874 - 883, 2017.
ISNAD	Kanat, Ayhan vd. "Predictive Role of External Carotid Artery Vasospasm on Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental Study". Turkish Neurosurgery 27/6 (2017), 874-883.