Introduction: Anaphylaxis is a severe hypersensitivity reaction that can be lifethreatening. The frequency of anaphylaxis varies among the societies. In this study, the demographic characteristics, clinical course, triggering agents and treatment approaches of the patients who were diagnosed with anaphylaxis in our pediatric allergy clinic were evaluated. Materials and Methods: The medical records of children who received a diagnosis of anaphylaxis between 2010 and 2012 were retrospectively evaluated. Results: Between 2010 and 2012, 39.371 patients were admitted to our outpatient clinic. Sixty-six patients (49 male, 17 female) with a mean age of 8.9±5.3 years were evaluated as anaphylaxis. In 37 of the cases, anaphylactic attack occurred at home. Dermatological symptoms were the most frequent complaints. A probable cause of anaphylaxis was identified in all the patients except for five of them (92.4%). Food was the cause of anaphylaxis in 25 of the cases, followed by hymenoptera sting in 22 patients and drugs in 14 patients. The most common causes of anaphylaxis according to age groups were food, hymenoptera sting and drugs (0-3 years, 4-14 years and over the age of 14, respectively). Antihistamines were applied to all patients. The other medications that were applied were corticosteroid, oxygen, intravenous fluids, adrenaline (21/66), and salbutamol. Conclusions: The common cause of anaphylaxis in children is food allergens. However, the frequency decreases by age and other causes are more common than food. In our country, usage of adrenaline for the treatment of anaphylaxis is low.