ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

ATEŞ, HACI ÖMER

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

HACI ÖMER ATEŞ (Boş)

Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi

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Yıl: 2017 Cilt: 18 Sayı: 1 Sayfa Aralığı: 7 - 12 Metin Dili: Türkçe İndeks Tarihi: 04-12-2018

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Öz:

AMAÇ: Alopesi Areata patogenezinde, değiş-miş T hücre aracılı bağışıklığın rol aldığını göste-ren çok sayıda çalışma bulunmaktadır. Sitokin-lerin ve kemokinlerin Alopesi Areata’nın immun sürecinde önemli rol oynamasından dolayı, Alo-pesi Areata’ya yatkınlık ile TNF-α-308G/A poli-morfizmi arasındaki olası bağlantının Türk po-pulasyonunda araştırılması amacıyla bu çalışma gerçekleştirildi.GEREÇ VE YÖNTEM: Sunulan vaka kontrol ça-lışmasına 107 Alopesi Areata hastası ve 113 sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A polimorfizminin genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.BULGULAR: Hasta ve kontrol gruplarında TNF-α-308 G/A genotiplerinin ve allel frekans-larının dağılımı arasında anlamlı bir bağlantı bulunamadı (p=0.673 ve p=0.177, sırasıyla). Benzer şekilde, TNF-α-308 G/A polimorfizmi ile Alopesi Areata’nın klinik bulguları arasında fark tespit edilemedi.SONUÇ: Bu çalışma, TNF-α-308 G/A polimor-fizminin Türk populasyonunda Alopesi Areata gelişiminde önemli bir rol oynamadığını gös-termektedir.

Anahtar Kelime:

Konular: Hematoloji

ANALYSIS OF TNF-α PROMOTER POLYMORPHISM IN ALOPECIA AREATA

Öz:

OBJECTIVE: Most evidence supports the role of altered T cell-mediated immunity in the pat-hogenesis of alopecia areata. As though cyto-kines and chemokines play an important role in the immune process of Alopesi Areata, the purpose of the present study was to investigate possible associations between TNF-α-308G/A polymorphism and Alopesi Areata susceptibi-lity, and disease progression in Turkish popula-tion. MATERIALS AND METHODS: This case-control study included 107 unrelated patients with Alo-pesi Areata and 113 unrelated healthy controls. The genotyping of TNF-α-308G/A polymorp-hism was performed using polymerase chain reaction (PCR) combined with restriction enzy-me analysis (REA). RESULTS: No statistically significant associati-ons was found between Alopesi Areata patients and healthy subjects fort the TNF-α-308G/A ge-notypic and allelic distribution (p=0.673 and p=0.177, respectively). Similarly, no significant differences was observed between TNF-α-308G/A polymorphism and clinical manifestati-ons of Alopesi Areata. CONCLUSION: This study indicates that TNF-α-308G/A polymorphism do not play a significant role in Alopesi Areata susceptibility in Turkish Alopesi Areata patients.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ATEŞ H (2017). ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. , 7 - 12.
Chicago	ATEŞ HACI ÖMER ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. (2017): 7 - 12.
MLA	ATEŞ HACI ÖMER ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. , 2017, ss.7 - 12.
AMA	ATEŞ H ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. . 2017; 7 - 12.
Vancouver	ATEŞ H ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. . 2017; 7 - 12.
IEEE	ATEŞ H "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ." , ss.7 - 12, 2017.
ISNAD	ATEŞ, HACI ÖMER. "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ". (2017), 7-12.

APA	ATEŞ H (2017). ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 18(1), 7 - 12.
Chicago	ATEŞ HACI ÖMER ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 18, no.1 (2017): 7 - 12.
MLA	ATEŞ HACI ÖMER ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, vol.18, no.1, 2017, ss.7 - 12.
AMA	ATEŞ H ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2017; 18(1): 7 - 12.
Vancouver	ATEŞ H ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2017; 18(1): 7 - 12.
IEEE	ATEŞ H "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ." Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 18, ss.7 - 12, 2017.
ISNAD	ATEŞ, HACI ÖMER. "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ". Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 18/1 (2017), 7-12.