Interleukin-1 gene variants and the risk of non-syndromic microtia
Yıl: 2018 Cilt: 11 Sayı: 2 Sayfa Aralığı: 89 - 94 Metin Dili: İngilizce DOI: 10.5505/ptd.2017.94557 İndeks Tarihi: 04-01-2019
Interleukin-1 gene variants and the risk of non-syndromic microtia
Öz: Purpose: Microtia is a congenital anomaly, manifested by a small and disfigured auricle. Interleukin (IL) 1 is animportant mediator of inflammation and cartilage destruction, This study is aimed at investigating association ofIL-1A (-889) and IL-1B (-511) variants in a Turkish patient population with microtia.Meterials and Methods: Nineteen patients diagnosed with microtia and 40 healthy controls were enrolled to thestudy. The IL-1A (-889) and IL-1B (-511) variants were evaluated using the polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP) method. For statistical analysis, SPSS version 22.0 was used.Results: The genotype distribution of the IL-1A (-889) variant was statistically different between the cases andthe control group. IL-1A -889 CC genotype was lower in microtia cases while TT genotype was more prevalentin microtia cases, respectively (p=0.008, p=0.008). High difference was also observed when the patient groupand the control group were compared according to IL-1 (-889) CT+TT (p=0.003). IL-1A (-889) C allele was lowerin microtia patients and T allele was higher in patients (p=0.005). The allele frequency and genotype distributionof IL-1B (-511) CT variant did not show any statistically difference between patients and controls (p>0.05).Conclusion: To our knowledge, for the first time in the literature we have demonstrated a significant associationof the IL-1A (-889) functional variant with microtia in a Turkish cohort.
Anahtar Kelime: İnterlökin 1 gen varyantları ve sendromik olmayan mikrotia riski
Öz: Amaç:Mikrotia küçük ve şekil bozukluğu olan kulak kepçesi ile görülen kongenital bir anomalidir. İnterlökin (IL) 1 enflamasyon ve kıkırdak harabiyeti için önemli bir düzenleyicidir. Bu çalışma Türk mikrotia hastalarında IL-1A (-889) ve IL-1B (-511) varyantlarının ilişkisini değerlendirmeyi amaçlamıştır. Gereç ve Yöntem: Çalışmaya mikrotia tanılı 19 hasta ve 40 sağlıklı kontrol dahil edilmiştir. IL-1A (-889) ve IL-1B (-511) varyantları polimeraz zincir reaksiyonu (PZR)- sınırlayıcı parça uzunluk polimorfizm (RFLP) yöntemi ile incelenmiştir. İstatistik analiz için, SPSS 22.0 versiyonu kullanılmıştır. Bulgular:IL-1A (-889) varyant genotip dağılımı hastalar ve kontrol grubu arasında istatistiksel olarak farklıydı. IL-1A -889 TT genotipi mikrotia hastalarında daha yaygınken, CC genotipi mikrotia hastalarında daha azdı, sırasıyla (p=0.008, p=0.008). Hasta ve kontrol grupları IL-1 (-889) CT+TT durumuna göre karşılaştırıldığında büyük fark saptandı (p=0.003). IL-1A (-889) C alleli mikrotia hastalarında azdı ve T alleli hastalarda çoktu (p=0.005). IL-1B (-511) CT varyant genotip ve allel dağılımı hastalar ve kontrol arasında herhangi istatistiksel fark göstermedi (p>0.05). Sonuç:Bildiğimiz kadarıyla literatürde ilk olarak, IL-1A (-889) fonksiyonel varyantın Türk topluluğunda mikrotia ile önemli ilişkisi olduğunu gösterdik.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Nursal A, BEKERECİOĞLU M, BÜYÜKGÜRAL B, pehlivan s (2018). Interleukin-1 gene variants and the risk of non-syndromic microtia. , 89 - 94. 10.5505/ptd.2017.94557 |
| Chicago | Nursal Ayse Feyda,BEKERECİOĞLU MEHMET,BÜYÜKGÜRAL Berker,pehlivan sacide Interleukin-1 gene variants and the risk of non-syndromic microtia. (2018): 89 - 94. 10.5505/ptd.2017.94557 |
| MLA | Nursal Ayse Feyda,BEKERECİOĞLU MEHMET,BÜYÜKGÜRAL Berker,pehlivan sacide Interleukin-1 gene variants and the risk of non-syndromic microtia. , 2018, ss.89 - 94. 10.5505/ptd.2017.94557 |
| AMA | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s Interleukin-1 gene variants and the risk of non-syndromic microtia. . 2018; 89 - 94. 10.5505/ptd.2017.94557 |
| Vancouver | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s Interleukin-1 gene variants and the risk of non-syndromic microtia. . 2018; 89 - 94. 10.5505/ptd.2017.94557 |
| IEEE | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s "Interleukin-1 gene variants and the risk of non-syndromic microtia." , ss.89 - 94, 2018. 10.5505/ptd.2017.94557 |
| ISNAD | Nursal, Ayse Feyda vd. "Interleukin-1 gene variants and the risk of non-syndromic microtia". (2018), 89-94. https://doi.org/10.5505/ptd.2017.94557 |
| APA | Nursal A, BEKERECİOĞLU M, BÜYÜKGÜRAL B, pehlivan s (2018). Interleukin-1 gene variants and the risk of non-syndromic microtia. Pamukkale Tıp Dergisi, 11(2), 89 - 94. 10.5505/ptd.2017.94557 |
| Chicago | Nursal Ayse Feyda,BEKERECİOĞLU MEHMET,BÜYÜKGÜRAL Berker,pehlivan sacide Interleukin-1 gene variants and the risk of non-syndromic microtia. Pamukkale Tıp Dergisi 11, no.2 (2018): 89 - 94. 10.5505/ptd.2017.94557 |
| MLA | Nursal Ayse Feyda,BEKERECİOĞLU MEHMET,BÜYÜKGÜRAL Berker,pehlivan sacide Interleukin-1 gene variants and the risk of non-syndromic microtia. Pamukkale Tıp Dergisi, vol.11, no.2, 2018, ss.89 - 94. 10.5505/ptd.2017.94557 |
| AMA | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s Interleukin-1 gene variants and the risk of non-syndromic microtia. Pamukkale Tıp Dergisi. 2018; 11(2): 89 - 94. 10.5505/ptd.2017.94557 |
| Vancouver | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s Interleukin-1 gene variants and the risk of non-syndromic microtia. Pamukkale Tıp Dergisi. 2018; 11(2): 89 - 94. 10.5505/ptd.2017.94557 |
| IEEE | Nursal A,BEKERECİOĞLU M,BÜYÜKGÜRAL B,pehlivan s "Interleukin-1 gene variants and the risk of non-syndromic microtia." Pamukkale Tıp Dergisi, 11, ss.89 - 94, 2018. 10.5505/ptd.2017.94557 |
| ISNAD | Nursal, Ayse Feyda vd. "Interleukin-1 gene variants and the risk of non-syndromic microtia". Pamukkale Tıp Dergisi 11/2 (2018), 89-94. https://doi.org/10.5505/ptd.2017.94557 |
