Nietzsche who is one of the most prominent phlosophers of the intellectual history of West has affected the movements such as; both nihilism, anarchism and postmodernism and philosophers like Derrida and Baudrillard. Nietzsche who also affected transhumanism providing the transformation of nature and human via technology has great impress on the trans-posthumanist approaches emerged as an important improvement and supplying the transformation of nature and human by means of technology. Nietzsche and transhumanism have not been studied, as the number of studies in the field of transhumanism in our country is very limited. In recent years, there are many articles and books written in the context of transhumanism and Nietzsche in the Western philosophical literature where discussions relating Nietzsche to transhumanism are done. Subjects and concepts related to Nietzschetranshumanism have been ; superman-posthuman, eternal cycle, the will to power, nihilism, evolution, education, asceticism, development, bio-development, morality, pain, grief, longevity and immortality. In this article, Nietzsche-transhuman relation is discussed with the concepts of superman, the will to power and eternal cycle and Nietzsche's similarity and difference with the transhumanism movement is handled as well. Although the transhumanism is claimed to have the roots of Nietzsche, it is stated that the anti-humanist philosophy of Nietzsche, is different from transhumanism, which wants humanism to move further.