Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy
Yıl: 2018 Cilt: 25 Sayı: 1 Sayfa Aralığı: 18 - 21 Metin Dili: İngilizce DOI: 10.5455/jtomc.2017.09.121 İndeks Tarihi: 27-09-2018
Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy
Öz: Aim: The aim of this study was to evaluate the changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels in patients with morbid obesity after laparoscopic sleeve gastrectomy (LSG).Material and Methods: A total of 85 patients who underwent LSG operation with the diagnosis of morbid obesity were included in the study. Levels of vitamin B12, ferritin, folic acid, and thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) hormone were measured using the chemiluminescence method. Pre- and postoperative levels of thyroid hormones, vitamin B12, ferritin, folic acid, and BMI values were evaluated.Results: The mean BMI decreased from 45.44 ± 3.8 kg/m2 to 39.38 ± 3.69 kg/m2 (p<0.001). The mean TSH, fT3, vitamin B12, folic acid, and ferritin levels were statistically significant lower at six months postoperatively than preoperative levels, while the mean fT4 levels were found to be significantly higher (p<0.001). Preoperative and 6thmonth postoperative ferritin levels were significantly lower in female patients than male patients (p<0.001). There was a negative correlation between age with preoperative TSH and fT3 levels. There was a positive correlation between age and preoperative and 6thmonth postoperative folic acid levels.Conclusion: Remodeling of the gastrointestinal system and endocrine alterations after LSG may result in changes in the levels of nutritional parameters such as thyroid hormone, vitamin B12, folic acid, and ferritin. Therefore, based on our study findings, we consider that the nutritional status of patients after bariatric surgery should be monitored particularly in long-term and nutritionallysupported, if necessary.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Pellitero S, Martínez E, Puig R, Leis A, Zavala R, Granada ML, et al. Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term. Obes Surg 2017;27(7):1674-82.
- Saif T, Strain GW, Dakin G, Gagner M, Costa R, Pomp A. Evaluation of nutrient status after laparoscopic sleeve gastrectomy 1, 3, and 5 years after surgery. Surg Obes Relat Dis 2012;8(5):542-7.
- Fried M, Yumuk V, Oppert JM, Scopinaro N, Torres A, Weiner R, et al. International Federation for Surgery of obesity and metabolic disorders-European chapter (IFSO-EC); European Association for the Study of Obesity (EASO); European Association for the Study of obesity obesity management task force (EASO OMTF). Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes Surg 2014;24(1):42-55.
- Fontenelle LC, Feitosa MM, Severo JS, Freitas TE, Morais JB, Torres-Leal FL, et al. Thyroid function in human obesity: Underlying mechanisms. Horm Metab Res 2016;48(12):787-94.
- Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005;90(7):4019-24.
- Bakiner O, Bozkirli E, Cavlak G, Ozsahin K, Ertorer E. Are plasma thyroid-stimulating hormone levels associated with degree of obesity and metabolic syndrome in euthyroid obese patients? A turkish cohort study. ISRN Endocrinol 2014;2;2014.
- Ortega E, Pannacciulli N, Bogardus C, Krakoff J. Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. Am J Clin Nutr 2007;85(2):440-5.
- Macek Jílková Z, Pavelka S, Flachs P, Hensler M, Kus V, Kopecký J. Modulation of type I iodothyronine 5′-deiodinase activity in white adipose tissue by nutrition: possible involvement of leptin. Physiol Res 2010;59(4):561-9.
- Bétry C, Challan-Belval MA, Bernard A, Charrié A, Drai J, Laville M, et al. Increased TSH in obesity: evidence for a BMI-independent association with leptin. Diabetes Metab 2015;41(3):248-51.
- Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol 2010;24(12):2366-81.
- Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev 2014;94(2):355-82.
- Ren R, Jiang X, Zhang X, Guan Q, Yu C, Li Y, et al. Association between thyroid hormones and body fat in euthyroid subjects. Clin Endocrinol (Oxf) 2014;80(4):585-90.
- Padwal R, Klarenbach S, Wiebe N, Birch D, Karmali S, Manns B, et al. Bariatric surgery: a systematic review and network meta-analysis of randomized trials. Obes Rev 2011;12(8):602-21.
- Kozlowska L, Rosolowska-Huszcz D. Leptin, thyrotropin and thyroid hormones in obese/overweight women before and after two levels of energy deficit. Endocrine 2004;24(2):147-53.
- Michalaki MA, Vagenakis AG, Leonardou AS, Argentou MN, Habeos IG, Makri MG, et al. Thyroid function in humans with morbid obesity. Thyroid 2006;16(1):73-8.
- Álvarez-Castro P, Sangiao-Alvarellos S, Brandón-Sandá I, Cordido F. Endocrina Funcion in obesity. Endocrinol Nutr 2011;58(8):422-32.
- Swınburn BA, Caterson I, Seıdell JC, James WP. Diet, nutrition and the prevention of excess weight gain and obesity. Public Health Nutr 2004;7(1):123-46.
- Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29: 415-45.
- Schauer PR, Schirmer BD. The surgical management of obesity. In: Schwartz SI, editor. Principles of Surgery, 10nd edition. New York: McGraw-Hill; 2015;p.1099.
| APA | Doğan U, ORUÇ M (2018). Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. , 18 - 21. 10.5455/jtomc.2017.09.121 |
| Chicago | Doğan Uğur,ORUÇ Mehmet Tahir Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. (2018): 18 - 21. 10.5455/jtomc.2017.09.121 |
| MLA | Doğan Uğur,ORUÇ Mehmet Tahir Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. , 2018, ss.18 - 21. 10.5455/jtomc.2017.09.121 |
| AMA | Doğan U,ORUÇ M Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. . 2018; 18 - 21. 10.5455/jtomc.2017.09.121 |
| Vancouver | Doğan U,ORUÇ M Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. . 2018; 18 - 21. 10.5455/jtomc.2017.09.121 |
| IEEE | Doğan U,ORUÇ M "Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy." , ss.18 - 21, 2018. 10.5455/jtomc.2017.09.121 |
| ISNAD | Doğan, Uğur - ORUÇ, Mehmet Tahir. "Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy". (2018), 18-21. https://doi.org/10.5455/jtomc.2017.09.121 |
| APA | Doğan U, ORUÇ M (2018). Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 25(1), 18 - 21. 10.5455/jtomc.2017.09.121 |
| Chicago | Doğan Uğur,ORUÇ Mehmet Tahir Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 25, no.1 (2018): 18 - 21. 10.5455/jtomc.2017.09.121 |
| MLA | Doğan Uğur,ORUÇ Mehmet Tahir Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.25, no.1, 2018, ss.18 - 21. 10.5455/jtomc.2017.09.121 |
| AMA | Doğan U,ORUÇ M Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2018; 25(1): 18 - 21. 10.5455/jtomc.2017.09.121 |
| Vancouver | Doğan U,ORUÇ M Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2018; 25(1): 18 - 21. 10.5455/jtomc.2017.09.121 |
| IEEE | Doğan U,ORUÇ M "Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 25, ss.18 - 21, 2018. 10.5455/jtomc.2017.09.121 |
| ISNAD | Doğan, Uğur - ORUÇ, Mehmet Tahir. "Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 25/1 (2018), 18-21. https://doi.org/10.5455/jtomc.2017.09.121 |
