Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

KIZILTUNÇ, Emrullah; TAÇOY, GÜLTEN; SEZENÖZ, Burak; ÖZKAN, Selçuk; ALSANCAK, Yakup; sivri, serkan; Demir Alsancak, Aybüke

Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

Emrullah KIZILTUNÇ, (Ankara Numune Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, Ankara, Türkiye)

Yakup ALSANCAK, (SB Ankara Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Burak SEZENÖZ, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Selçuk ÖZKAN, (Girilmedi)

Serkan SİVRİ, (SB Ankara Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Aybüke Demir ALSANCAK, (Ankara Numune Eğitim ve Araştırma Hastanesi, Aile Hekimliği Kliniği, Ankara, Türkiye)

Gülten TAÇOY (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Koşuyolu Heart Journal

3 0

Yıl: 2017 Cilt: 20 Sayı: 1 Sayfa Aralığı: 30 - 35 Metin Dili: İngilizce İndeks Tarihi: 05-10-2018

Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

Öz:

Introduction: Circulating monocyte count is predictive of new atherosclerotic plaque development. In addition, there is a strong inverse relationship between high-density lipoprotein (HDL) cholesterol and atherosclerosis. We aimed to investigate the relationship between the monocyte/HDL cholesterol ratio and severity of coronary artery disease.Patients and Methods: A total of 760 patients who underwent coronary angiography were included in the study. The severity of coronary atherosclerosis was calculated by the Gensini score, and the patients were grouped as having low (< 20) and high (> 20) Gensini scores. Baseline characteristics and laboratory parameters were recorded and compared between patients with low and high Gensini scores.Results: Hypertension, diabetes mellitus, hyperlipidaemia, advanced age and smoking were more common in patients with a high Gensini score. Fasting blood glucose levels, creatinine levels and monocyte/HDL cholesterol ratio were significantly lower in patients with a low Gensini score than in those with a high Gensini score. Logistic regression analysis revealed that older age, fasting blood glucose levels, hyperlipidaemia, family history of coronary artery disease and male gender were independent predictors of a high Gensini score. We observed a correlation between the monocyte/HDL cholesterol ratio and Gensini score (p< 0.001). However, this correlation was weak (Spearman’s rho = 0.159).Conclusion: We observed a positive but weak correlation between the monocyte/HDL cholesterol; ratio and increased coronary atherosclerotic burden, as calculated by Gensini scoring. Further studies are required to demonstrate the relationship between the monocyte/HDL cholesterol ratio and atherosclerotic cardiovascular disease.

Anahtar Kelime:

Konular: Periferik Damar Hastalıkları Anestezi Kalp ve Kalp Damar Sistemi

Monosit Sayısı/HDL Oranı ile Koroner Arter Hastalığının Ciddiyeti ve Yaygınlığı Arasındaki İlişki

Öz:

Giriş: Kan dolaşımında bulunan monosit sayısı yeni aterosklerotik plak oluşumunda öngörücüdür. Bununla birlikte yüksek dansiteli lipoprotein kolesterol (HDL) düzeyleri ile ateroskleroz arasında güçlü bir negatif ilişki vardır. Bu çalışmada, monosit sayısı/HDL oranıyla koroner arter hastalığı ciddiyeti arasındaki ilişkiyi değerlendirmeyi amaçladık. Hastalar ve Yöntem: Koroner anjiyografi yapılan toplam 760 hasta çalışmaya dahil edildi. Koroner aterosk- leroz ciddiyeti Gensini skorlama sistemi kullanılarak değerlendirildi ve hastalar Gensini skorlarına göre yük- sek (> 20) ve düşük (< 20) olarak iki gruba ayrıldı. Bazal karakteristik özellikler ve laboratuvar parametreleri kaydedilerek yüksek ve düşük Gensini skoru olan hastalar arasında karşılaştırıldı. Bulgular: Hipertansiyon, diabetes mellitus, hiperlipidemi, ileri yaş ve sigara içiciliği yüksek Gensini skoru olan hastalarda daha fazlaydı. Açlık kan şekeri, kreatinin düzeyleri ve monosit/HDL oranı düşük Gensini skoru olan hastalarda yüksek Gensini skoru olanlara kıyasla daha düşüktü. Lojistik regresyon analizinde ile- ri yaş, açlık kan şekeri, hiperlipidemi, aile öyküsü ve erkek cinsiyetin yüksek Gensini skoru için bağımsız parametreler olduğu gözlendi. Monosit/HDL oranının, Gensini skoruyla korele olduğu (p< 0.001) ancak bu korelasyonun çok zayıf olduğu tespit edildi (Spearman’s Rho: 0.159). Sonuç: Monosit/HDL oranı ile Gensini skoruyla elde edilen ateroskleroz yaygınlığı arasında zayıf da olsa bir ilişki izlenmiştir. Ancak Monosit/HDL oranı ve aterosklerotik kalp hastalığı arasındaki ilişkiyi belirlemek için daha fazla klinik çalışmaya ihtiyaç vardır.

Anahtar Kelime:

Konular: Periferik Damar Hastalıkları Anestezi Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KIZILTUNÇ E, ALSANCAK Y, SEZENÖZ B, ÖZKAN S, sivri s, Demir Alsancak A, TAÇOY G (2017). Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. , 30 - 35.
Chicago	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. (2017): 30 - 35.
MLA	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. , 2017, ss.30 - 35.
AMA	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. . 2017; 30 - 35.
Vancouver	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. . 2017; 30 - 35.
IEEE	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease." , ss.30 - 35, 2017.
ISNAD	KIZILTUNÇ, Emrullah vd. "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease". (2017), 30-35.

APA	KIZILTUNÇ E, ALSANCAK Y, SEZENÖZ B, ÖZKAN S, sivri s, Demir Alsancak A, TAÇOY G (2017). Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Heart Journal, 20(1), 30 - 35.
Chicago	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Heart Journal 20, no.1 (2017): 30 - 35.
MLA	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Heart Journal, vol.20, no.1, 2017, ss.30 - 35.
AMA	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Heart Journal. 2017; 20(1): 30 - 35.
Vancouver	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Heart Journal. 2017; 20(1): 30 - 35.
IEEE	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease." Koşuyolu Heart Journal, 20, ss.30 - 35, 2017.
ISNAD	KIZILTUNÇ, Emrullah vd. "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease". Koşuyolu Heart Journal 20/1 (2017), 30-35.