Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis
Yıl: 2018 Cilt: 25 Sayı: 2 Sayfa Aralığı: 252 - 257 Metin Dili: İngilizce DOI: 10.5455/jtomc.2018.02.036 İndeks Tarihi: 27-03-2019
Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis
Öz: Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially in cases where it is difficult to diagnose spondylodiscitis.Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017. After excluding the cases that did not meet the inclusion criteria (n=6), the remaining cases (n=24) were referred to as the study group. A control group was created from healthy volunteers (n=24) who applied for routine physical checkups at the clinic between the same dates and who were similar in terms of age, sex, and body mass index to the study group. Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared.Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value.Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Aktar F, Tekin R, Bektaş MS, Güneş A, Köşker M, Ertuğrul S, et al. Diagnostic role of inflammatory markers in pediatric
- Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 2009;39(1):10-7.
- Lemaignen A, Ghout I, Dinh A, Gras G, Fantin B, Zarrouk V, et al. Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: a case-control study. Medicine (Baltimore) 2017;96(21):e6387.
- Niemier K, Schindler M, Volk T, Baum K, Wolf B, Eberitsch J, et al. Efficacy of epidural steroid injections for chronic lumbar pain syndromes without neurological deficits. A randomized, double blind study as part of a multimodal treatment concept. Schmerz 2015;29(3):300-7.
- Sur A, Tsang K, Brown M, Tzerakis N. Management of adult spontaneous spondylodiscitis and its rising incidence. Ann R Coll Surg Engl 2015;97(6):451-5.
- Wang X, Tao H, Zhu Y, Lu X, Hu X. Management of postoperative spondylodiscitis with and without internal fixation. Turk Neurosurg 2015;25(4):513-8.
- Fransen BL, de Visser E, Lenting A, Rodenburg G, van Zwet AA, Gisolf EH. Recommendations for diagnosis and treatment of spondylodiscitis. Neth J Med 2014;72(3):135-8.
- Madert J, Liem M, Frosch KH, Niemeyer T. Dorsolateral access and interbody spinal fusion in spondylodiscitis of the thoracolumbar spine (TLIF technique). Oper Orthop Traumatol 2013;25(3):262-72.
- Pola E, Autore G, Formica VM, Pambianco V, Colangelo D, Cauda R, et al. New classification for the treatment of pyogenic spondylodiscitis: validation study on a population of 250 patients with a follow-up of 2 years. Eur Spine J 2017;26(9):2476-77.
- Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage. Neurocrit Care 2017;26(3):393-401.
- Wang PF, Song HW, Cai HQ, Kong LW, Yao K, Jiang T, et al. Preoperative inflammation markers and IDH mutation status predict glioblastoma patient survival. Oncotarget 2017;8(30):50117-23.
- Chen W, Yang J, Li B, Peng G, Li T, Li L, et al. Neutrophil to lymphocyte ratio as a novel predictor of outcome in patients with severe traumatic brain injury. J Head Trauma Rehabil 2018;33(1):53-9.
- Bilir B, Isyar M, Yilmaz I, Saracoglu GV, Cakmak S, Dogan M, et al. Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in septic arthritis. European Journal of Inflammation 2015;13(3):196-203.
- Akcam FZ, Kaya O, Ceylan T. Comment on: Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 2011;66(5):1199-200.
- Rankine JJ, Barron DA, Robinson P, Millner PA, Dickson RA. Therapeutic impact of percutaneous spinal biopsy in spinal infection. Postgrad Med J 2004;80(948):607-9.
- Gupta P, Ehlert M, Bartley J, Gilleran J, Killinger KA, Boura JA, et al. Perioperative outcomes, complications, and efficacy of robotic-assisted prolapse repair: a single institution study of 196 patients. Female Pelvic Med Reconstr Surg 2017;15.
- McNamara AL, Dickerson EC, Gomez-Hassan DM, Cinti SK, Srinivasan A. Yield of image-guided needle biopsy for infectious discitis: a systematic review and meta-analysis. AJNR Am J Neuroradiol 2017;38(10): 2021-7.
- Rehm J, Veith S, Akbar M, Kauczor HU, Weber MA. CT-guided percutaneous spine biopsy in suspected infection or malignancy: a study of 214 patients. Rofo. 2016;188(12):1156-62.
- Frel M, Białecki J, Wieczorek J, Paluch Ł, Dąbrowska-Thing A, Walecki J. Magnetic resonance imaging in differentatial diagnosis of pyogenic spondylodiscitis and tuberculous spondylodiscitis. Pol J Radiol 2017;82:71-87
- Colmenero JD, Jiménez-Mejías ME, Sánchez-Lora FJ, Reguera JM, Palomino-Nicás J, Martos F, et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 1997;56(12):709-15.
- Zimmerly W. Clinical practice. vertebral osteomyelitis. N Eng J Med 2010;362(11):1022-9.
- Homagk L, Homagk N, Klauss JR, Roehl K, Hofmann GO, Marmelstein D. Spondylodiscitis severity code: scoring system for the classification and treatment of non-specific spondylodiscitis. Eur Spine J 2016;25(4):1012-20.
- Beronius M, Bergman B, Andersson R. Vertebral osteomyelitis in Göteborg, Sweden: a retrospective study of patients during 1990-95. Scand J Infect Dis 2001;33(7):527-32.
- Quesnele J, Dufton J, Stern P. Spinal infection: a case report. J Can Chiropr Assoc 2012;56(3):209-15.
- Tsujimoto T, Takahata M, Kokabu T, Matsuhashi M, Iwasaki N. Pyogenic spondylodiscitis following anti-interleukin-6 therapy in a patient with rheumatoid arthritis (implication of hematogenous infection risk in degenerative intervertebral discs): a case report and review of the literature. J Orthop Sci 2016;21(5):694-7.
- Fantoni M, Trecarichi EM, Rossi B, Mazzotta V, Di Giacomo G, Nasto LA, et al. Epidemiological and clinical features of pyogenic spondylodiscitis. Eur Rev Med Pharmacol Sci 2012;16 Suppl 2:2-7.
| APA | Karaarslan N, Yılmaz İ, AKGÜN F, CALISKAN T, DOĞAN M, bilir b, ATEŞ Ö (2018). Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. , 252 - 257. 10.5455/jtomc.2018.02.036 |
| Chicago | Karaarslan Numan,Yılmaz İbrahim,AKGÜN FERİDE SİNEM,CALISKAN Tezcan,DOĞAN Mustafa,bilir bulent,ATEŞ Özkan Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. (2018): 252 - 257. 10.5455/jtomc.2018.02.036 |
| MLA | Karaarslan Numan,Yılmaz İbrahim,AKGÜN FERİDE SİNEM,CALISKAN Tezcan,DOĞAN Mustafa,bilir bulent,ATEŞ Özkan Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. , 2018, ss.252 - 257. 10.5455/jtomc.2018.02.036 |
| AMA | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. . 2018; 252 - 257. 10.5455/jtomc.2018.02.036 |
| Vancouver | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. . 2018; 252 - 257. 10.5455/jtomc.2018.02.036 |
| IEEE | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö "Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis." , ss.252 - 257, 2018. 10.5455/jtomc.2018.02.036 |
| ISNAD | Karaarslan, Numan vd. "Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis". (2018), 252-257. https://doi.org/10.5455/jtomc.2018.02.036 |
| APA | Karaarslan N, Yılmaz İ, AKGÜN F, CALISKAN T, DOĞAN M, bilir b, ATEŞ Ö (2018). Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research, 25(2), 252 - 257. 10.5455/jtomc.2018.02.036 |
| Chicago | Karaarslan Numan,Yılmaz İbrahim,AKGÜN FERİDE SİNEM,CALISKAN Tezcan,DOĞAN Mustafa,bilir bulent,ATEŞ Özkan Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research 25, no.2 (2018): 252 - 257. 10.5455/jtomc.2018.02.036 |
| MLA | Karaarslan Numan,Yılmaz İbrahim,AKGÜN FERİDE SİNEM,CALISKAN Tezcan,DOĞAN Mustafa,bilir bulent,ATEŞ Özkan Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research, vol.25, no.2, 2018, ss.252 - 257. 10.5455/jtomc.2018.02.036 |
| AMA | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research. 2018; 25(2): 252 - 257. 10.5455/jtomc.2018.02.036 |
| Vancouver | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research. 2018; 25(2): 252 - 257. 10.5455/jtomc.2018.02.036 |
| IEEE | Karaarslan N,Yılmaz İ,AKGÜN F,CALISKAN T,DOĞAN M,bilir b,ATEŞ Ö "Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis." Annals of Medical Research, 25, ss.252 - 257, 2018. 10.5455/jtomc.2018.02.036 |
| ISNAD | Karaarslan, Numan vd. "Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis". Annals of Medical Research 25/2 (2018), 252-257. https://doi.org/10.5455/jtomc.2018.02.036 |
