Objective: This study aims to assess the midterm results of locking compression plate (LCP) treatment that was inserted with minimally invasive percutaneous plate osteosynthesis (MIPPO) technique for open tibial fracture treatment. Methods: Treatment results of 41 patients (32 males, 9 females; mean age: 32 years; range: 16 to 64 years) who underwent open tibial fractures and were treated with MIPO technique between March 2008 and December 2009 were retrospectively analyzed. The Gustillo-Anderson classification was used in the classification of open fractures. Thirteen patients (31.7%) had Type I, 21 patients (51.2%) had Type II, six patients (14.6%) had Type IIIA, and one patient (2.4%) had Type IIIC. Functional results of the patients were assessed using the Karlstrom-Olerud functional evaluation criteria. Results: The mean follow-up was 18 months (range: 12 to 30 months). The mean time to union was 29 weeks (range: 20 to 60 weeks). A total of 38 of 41 patients had full union, while three had delayed union. Two patients had plate failure; plate was changed with an autograft in one and plate was changed alone in the other. According to the Karlstrom-Olerud scoring system, seven patients (17.1%) had excellent, 27 (65.9%) had good, four (9.8%) had intermediate, and three (7.3%) had satisfactory results. Ten patients had superficial infection, one patient developed deep infection, and one patient developed osteomyelitis. Superficial infections were treated with oral antibiotherapy, while deep infection and osteomyelitis were treated with serial debridement and parenteral antibiotherapy. Conclusions: Biological detection with MIPO technique is an effective method for urgent and permanent treatment of open tibial fractures with low infection and high union rates