Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers

SAĞLAMPINAR KARYAĞAR, Sevda; Karyağar, Savaş; BEKAR, Yıldıray; Koç, Zehra Pınar

Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers

Sevda SAĞLAMPINAR KARYAĞAR, (Okmeydanı Eğitim Hastanesi, Nükleer Tıp Kliniği, İstanbul, Türkiye)

Zehra PINAR KOÇ, (Fırat Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Elazığ, Türkiye)

Savaş KARYAĞAR, (SB. Okmeydanı Eğitim ve Araştırma Hastanesi, Nükleer Tıp Kliniği, İstanbul, Türkiye)

Yıldıray BEKAR (Trabzon Kanuni Eğitim ve Araştırma Hastanesi, Göğüs Cerrahisi Anabilim Dalı, Trabzon, Türkiye)

Türk Göğüs Kalp Damar Cerrahisi Dergisi

5 0

Yıl: 2017 Cilt: 25 Sayı: 2 Sayfa Aralığı: 235 - 241 Metin Dili: İngilizce İndeks Tarihi: 09-11-2018

Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers

Öz:

Background: This study aims to investigate the diagnostic performance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with solitary pulmonary nodules without smoking history.Methods: A total of 38 patients (25 females, 13 males; mean age 63±14 years; range 23 to 84 years) with solitary pulmonary nodules without smoking history who underwent 18F-FDG PET/CT imaging between June 2009 and March 2013 were retrospectively analyzed. Medical history was obtained from each patient, and malignancy was initially made by computed tomography in all patients. The diagnosis was further confirmed by either histopathological analysis results or at least two-year follow-up results.Results: The mean lesion diameter was 20±6 (range 8 to 28) mm. Eleven patients had a lung carcinoma, predominantly an adenocarcinoma (n=10), while 10 patients were found to have a FDG-avid tumor. The sensitivity, specificity, accuracy, and positive predictive and negative predictive values of 18F-FDG PET/CT were 91%, 63%, 71%, 50%, and 94%, respectively. All patients diagnosed with malignancy were women with an advanced age. Only one of the male patients had a malignant nodule.Conclusion: The sensitivity and negative predictive value of 18F-FDG PET/CT were found to be high in non-smoker patients with solitary pulmonary nodules, although adenocarcinomas were predominant in our study.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Sigara içmeyenlerde soliter pulmoner nodüllerde 18F-FDG PET/BT görüntülemenin tanısal gücü

Öz:

Amaç: Bu çalışmada, sigara içme öyküsü olmayan soliter pulmoner nodüllü hastalarda flor-18 florodeoksiglikoz pozitron emisyon tomografi/bilgisayarlı tomografinin (18F-FDG PET/BT) tanısal gücü araştırıldı. Çalışma planı: Haziran 2009 - Mart 2013 tarihleri arasında, sigara içme öyküsü olmayan, soliter pulmoner nodüllü olan, 18F-FDG PET/BT görüntülemesi yapılan toplam 38 hasta (25 kadın, 13 erkek; ort. yaş 63±14 yıl; dağılım 23 -84 yıl) retrospektif olarak incelendi. Her hastanın tıbbi öyküsü alındı ve malignite tanısı tüm hastalarda ilk olarak bilgisayarlı tomografi ile kondu. Tanı, daha sonra histopatolojik analiz sonuçları veya en az iki yıllık takip sonuçları ile doğrulandı. Bulgular: Ortalama lezyon çapı 20±6 (dağılım 8-28) mm idi. On bir hastada, çoğunluğunda adenokarsinom olmak üzere (n=10) akciğer karsinomu var iken, 10 hastada FDG tutan tümör saptandı. 18 F-FDG PET/BT’nin duyarlılığı, özgüllüğü ve doğruluğu, pozitif öngörü ve negatif öngörü değerleri sırasıyla %91, %63, %71, %50 ve %94 idi. Malignite tanısı konan hastaların tümü kadın ve ileri yaşta idi. Erkek hastalardan yalnız birinde malign nodül vardı. Sonuç: Çalışmamızda adenokarsinom baskın olmakla birlikte, sigara içmeyen soliter pulmoner nodüllü hastalarda 18F-FDG PET/BT’nin duyarlılığı ve negatif öngörü değeri yüksek bulundu.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SAĞLAMPINAR KARYAĞAR S, Koç Z, Karyağar S, BEKAR Y (2017). Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. , 235 - 241.
Chicago	SAĞLAMPINAR KARYAĞAR Sevda,Koç Zehra Pınar,Karyağar Savaş,BEKAR Yıldıray Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. (2017): 235 - 241.
MLA	SAĞLAMPINAR KARYAĞAR Sevda,Koç Zehra Pınar,Karyağar Savaş,BEKAR Yıldıray Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. , 2017, ss.235 - 241.
AMA	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. . 2017; 235 - 241.
Vancouver	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. . 2017; 235 - 241.
IEEE	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y "Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers." , ss.235 - 241, 2017.
ISNAD	SAĞLAMPINAR KARYAĞAR, Sevda vd. "Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers". (2017), 235-241.

APA	SAĞLAMPINAR KARYAĞAR S, Koç Z, Karyağar S, BEKAR Y (2017). Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 25(2), 235 - 241.
Chicago	SAĞLAMPINAR KARYAĞAR Sevda,Koç Zehra Pınar,Karyağar Savaş,BEKAR Yıldıray Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. Türk Göğüs Kalp Damar Cerrahisi Dergisi 25, no.2 (2017): 235 - 241.
MLA	SAĞLAMPINAR KARYAĞAR Sevda,Koç Zehra Pınar,Karyağar Savaş,BEKAR Yıldıray Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.25, no.2, 2017, ss.235 - 241.
AMA	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2017; 25(2): 235 - 241.
Vancouver	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2017; 25(2): 235 - 241.
IEEE	SAĞLAMPINAR KARYAĞAR S,Koç Z,Karyağar S,BEKAR Y "Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 25, ss.235 - 241, 2017.
ISNAD	SAĞLAMPINAR KARYAĞAR, Sevda vd. "Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers". Türk Göğüs Kalp Damar Cerrahisi Dergisi 25/2 (2017), 235-241.