Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule
Yıl: 2018 Cilt: 46 Sayı: 3 Sayfa Aralığı: 373 - 380 Metin Dili: İngilizce DOI: 10.15671/HJBC.2018.244 İndeks Tarihi: 12-11-2018
Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule
Öz: Anovel uracil derived compound, (E)-5-((3-chloro-2-hydroxybenzylidene)amino) pyrimidine-2,4(1H,3H)- dione, was synthesized and characterized using spectroscopic techniques. The interaction of the molecule with DNA was explored using computational methods which revealed that the molecule could act as a groove binder. The physicochemical properties of the molecule such as frontier molecule orbitals and chemical reactivity parameters were also investigated.
Anahtar Kelime: Konular:
Yeni Urasil Türevi Organik Bir Molekülün Sentezi, Yapısal Hesaplamaları ve Moleküler Modelleme Çalışmaları
Öz: Urasil türevi yeni bir bileşik, (E)-5-((3-klor-2-hidroksibenziliden)amino)pirimidin-2,4 (1H,3H)-dion, sentezlendi ve spektroskopik yöntemler kullanılarak yapı tayini gerçekleştirildi. Molekülün DNA ile olan etkileşimi, bilgisayar destekli yöntemler ile araştırıldı ve oluk bağlayıcı olarak davranabileceği belirlendi. Bileşiğin, molekül orbitalleri ve kimyasal reaktivite parametreleri gibi fizikokimyasal özellikleri incelendi.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KOZ G (2018). Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. , 373 - 380. 10.15671/HJBC.2018.244 |
| Chicago | KOZ GAMZE Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. (2018): 373 - 380. 10.15671/HJBC.2018.244 |
| MLA | KOZ GAMZE Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. , 2018, ss.373 - 380. 10.15671/HJBC.2018.244 |
| AMA | KOZ G Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. . 2018; 373 - 380. 10.15671/HJBC.2018.244 |
| Vancouver | KOZ G Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. . 2018; 373 - 380. 10.15671/HJBC.2018.244 |
| IEEE | KOZ G "Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule." , ss.373 - 380, 2018. 10.15671/HJBC.2018.244 |
| ISNAD | KOZ, GAMZE. "Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule". (2018), 373-380. https://doi.org/10.15671/HJBC.2018.244 |
| APA | KOZ G (2018). Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry, 46(3), 373 - 380. 10.15671/HJBC.2018.244 |
| Chicago | KOZ GAMZE Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry 46, no.3 (2018): 373 - 380. 10.15671/HJBC.2018.244 |
| MLA | KOZ GAMZE Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry, vol.46, no.3, 2018, ss.373 - 380. 10.15671/HJBC.2018.244 |
| AMA | KOZ G Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry. 2018; 46(3): 373 - 380. 10.15671/HJBC.2018.244 |
| Vancouver | KOZ G Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry. 2018; 46(3): 373 - 380. 10.15671/HJBC.2018.244 |
| IEEE | KOZ G "Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule." Hacettepe Journal of Biology and Chemistry, 46, ss.373 - 380, 2018. 10.15671/HJBC.2018.244 |
| ISNAD | KOZ, GAMZE. "Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule". Hacettepe Journal of Biology and Chemistry 46/3 (2018), 373-380. https://doi.org/10.15671/HJBC.2018.244 |
