OBJECTIVE: The incidence and prevalence of patients with chronic kidney disease (CKD) is increasing worldwi-de. It is often associated with a high prevalence of comp-lications and worse quality of life. The main objective of this study is to evaluate quality of life (QOL) using the generic instrument short form-36 (SF-36) in patients with CKD and identify the possible influence of the degree of renal function, age, gender, education level, socioecono-mic status, hemoglobin, albumin, HbA1c and 25 hydroxy vitamin D level on QOL. MATERIALS AND METHODS: For this cross-sectional study, we included 211 CKD patients ( median age 56 ± 13 years) admitted to the outpatient clinic of Antalya Re-search and Training Hospital Nephrology Unit between January and June 2016. Participants completed the short form-36 health survey (SF-36). Laboratory tests and clini-cal and demographic data were obtained. RESULTS: The patients were classified into CKD stages according to the CKD-EPI equation: 59,2% were in CKD Stage 1-3 and 40,8% were in Stage 4-5. The patients in Stage 4-5 had lower scores in physical aspects. Age influ-ence QOL negatively. CKD patients with higher hemoglo-bin, albumin and 25 hydroxy vitamin D levels has better functional capacity and physical aspects. High HbA1c le-vels significantly associated with bad functional capacity. Education level and socioeconomic status is associated with QOL. CONCLUSIONS: Renal function, age, gender, education level and socioeconomic status influenced QOL. To imro-ve QOL in CKD patients we need to focus on factors that can be changed, such as improving the hemoglobin, al-bumin, HbA1c and 25 hydroxy vitamin D levels.