OBJECTIVE: Cadmium (Cd), one of the major environmental pollutants used intensively in the industrial field and could ca-uses a variety of vital threats due to our exposure in our daily lives. Having a long half-life, Cd causes direct or indirect toxicity to respiratory, urinary, cardiovascular, gastrointestinal, nervous system and bones. It is known that Cd that accumulates in the body causes many diseases such as osteoporosis, anemia, eosi-nophilia, anosmia and chronic rhinitis. In our study, we aimed to investigate the role of tannic acid (TA), an antioxidant subs-tance with a high content of flavonoids and heavy metal che-lating agents, in order to investigate its role in protecting from Cd toxicity. MATERIALS AND METHODS: In this study, it was used 28 Spraque-Dawley, 200-300 gr, 3-4 monthly male rats. For pre-tre-atment, TA (50 mg/kg/day) was administered by intraperitoneal (i.p) injection to the experimental groups for 5 days. And then a single dose CdCl2 (35 mg/kg) was was administered by intra-gastric (i.g). RESULTS: It was observed that superoxide dismutase (SOD) values decreased in hemolysate, liver and kidney by CdCl2 ad-ministration; but increased with TA. Malondialdehyde (MDA) values increased with CdCl2 administration whereas decreased with TA the hemolysate and liver. TA was found to be effective in decreasing heart accumulation, while TA was not effective in reducing accumulation with CdCl2 administration in liver, kidney, lung, testis and spleen. TA is not effective in reducing increased iron accumulation with CdCl2 administration in the kidney, spleen and heart, but in liver, lung and testis it could be effective. CONCLUSIONS: Food and drinks used in the daily diet may increase the quality of life of individuals by early prevention of certain diseases that may result in exposure to toxic agents. In our study, it has been shown that TA, which is consumed in our daily lives, may be effective in protecting substances from he-avy metal toxicity. According to the results obtained, different results could be reached in different tissues; but when assessed in general, the harmful effects of Cd, or at least the result that TA have been achieved to reduce the accumulation of some tis-sues.