The management of invasive fungal infections (IFI) in immunosuppressive patients is a very important issue. Candida spp. and Aspergillus spp. are the most frequent causes of nosocomial IFIs. There are higher mortality rates in both of them. Due to there are no specific symptoms of IFIs, evaluating risk factors of those patients, taking appropriate samples in suspected cases, early diagnosis and prompt initiation of antifungal treatment are crucial behaviors for targeting satisfactory outcomes. In this article, we review "The Infectious Diseases Society of America (IDSA)", "The Infectious Diseases Working Party (AGIHO) and The German Society Hematology and Oncology (DGHO)", 'European Conference on Infections in Leukemia’ (ECIL) and "The European Society for Clinical Microbiology and Infectious Diseases (ESCMID)" guidelines and expert opinions. The appropriate treatment needs to be adjusted according to characteristics of patients and health care centers. Caspofungin, micafungin, anidulafungin, voriconazole or liposomal amphotericin B (LAmB) is the primary agents recommended for the treatment of candidemia in non-neutropenic patients according to specific criteria. Caspofungin, micafungin, anidulafungin or LAmB is the convenient agents for the management of neutropenic individuals, as well. Voriconazole is recommended for the treatment of invasive aspergillosis (IA). Besides posaconazole, LAmB or caspofungin is the antifungal agents for salvage treatment of IA. Empirical therapy for suspected candidemia in non-neutropenic patients, fluconazole, caspofungin, anidulafungin or micafungin is proper. Empirical therapy with an LFAmB, voriconazole, micafungin or caspofungin is recommended for suspected IA in neutropenic patients. As prophylaxis, fluconazole, posaconazole, voriconazole or echinocandins can be used for patients at risk of candidiasis according to the risk factors. According to primary disease posaconazole, voriconazole, itraconazole, micafungin or caspofungin is suggested as prophylaxis for IA. The goal of this review is to remind the main approaches for treatment of Candida and Aspergillus infections and to help determine a road map by searching current guidelines.