Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children

ŞİMŞEK ORHON, FİLİZ; Ulukol, Betul; BAŞKAN, Sevgi; siklar, zeynep; TUFAN, A. Çevik; TUFAN ŞATIROĞLU, N.Lale; ÖZHAN, Bayram; Alkan, Afra; AKYOL, Mesut; BERBEROĞLU, Merih; Topçu, Seda

Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children

Seda TOPÇU, (Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey)

Bayram ÖZHAN, (Pamukkale University Faculty of Medicine, Department of Pediatric Endocrinology, Denizli, Turkey)

Afra ALKAN, (Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey)

Mesut AKYOL, (Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey)

FİLİZ ŞİMŞEK ORHON, (Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey)

Sevgi BAŞKAN, (Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey)

Betül ULUKOL, (Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey)

Merih BERBEROĞLU, (Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey)

Zeynep ŞIKLAR, (Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey)

N.Lale TUFAN ŞATIROĞLU, (Ankara University Faculty of Medicine, Department of Forensic Medicine, Forensic Genetics Laboratory, Ankara, Turkey)

A. Çevik TUFAN, (Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey)

Diğer Yazarlar

Journal of Clinical Research in Pediatric Endocrinology

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Yıl: 2017 Cilt: 9 Sayı: 4 Sayfa Aralığı: 308 - 314 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children

Öz:

Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay.Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty.Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Topçu S, ÖZHAN B, Alkan A, AKYOL M, ŞİMŞEK ORHON F, BAŞKAN S, Ulukol B, BERBEROĞLU M, siklar z, TUFAN ŞATIROĞLU N, TUFAN A (2017). Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. , 308 - 314.
Chicago	Topçu Seda,ÖZHAN Bayram,Alkan Afra,AKYOL Mesut,ŞİMŞEK ORHON FİLİZ,BAŞKAN Sevgi,Ulukol Betul,BERBEROĞLU Merih,siklar zeynep,TUFAN ŞATIROĞLU N.Lale,TUFAN A. Çevik Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. (2017): 308 - 314.
MLA	Topçu Seda,ÖZHAN Bayram,Alkan Afra,AKYOL Mesut,ŞİMŞEK ORHON FİLİZ,BAŞKAN Sevgi,Ulukol Betul,BERBEROĞLU Merih,siklar zeynep,TUFAN ŞATIROĞLU N.Lale,TUFAN A. Çevik Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. , 2017, ss.308 - 314.
AMA	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. . 2017; 308 - 314.
Vancouver	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. . 2017; 308 - 314.
IEEE	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A "Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children." , ss.308 - 314, 2017.
ISNAD	Topçu, Seda vd. "Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children". (2017), 308-314.

APA	Topçu S, ÖZHAN B, Alkan A, AKYOL M, ŞİMŞEK ORHON F, BAŞKAN S, Ulukol B, BERBEROĞLU M, siklar z, TUFAN ŞATIROĞLU N, TUFAN A (2017). Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. Journal of Clinical Research in Pediatric Endocrinology, 9(4), 308 - 314.
Chicago	Topçu Seda,ÖZHAN Bayram,Alkan Afra,AKYOL Mesut,ŞİMŞEK ORHON FİLİZ,BAŞKAN Sevgi,Ulukol Betul,BERBEROĞLU Merih,siklar zeynep,TUFAN ŞATIROĞLU N.Lale,TUFAN A. Çevik Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. Journal of Clinical Research in Pediatric Endocrinology 9, no.4 (2017): 308 - 314.
MLA	Topçu Seda,ÖZHAN Bayram,Alkan Afra,AKYOL Mesut,ŞİMŞEK ORHON FİLİZ,BAŞKAN Sevgi,Ulukol Betul,BERBEROĞLU Merih,siklar zeynep,TUFAN ŞATIROĞLU N.Lale,TUFAN A. Çevik Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. Journal of Clinical Research in Pediatric Endocrinology, vol.9, no.4, 2017, ss.308 - 314.
AMA	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(4): 308 - 314.
Vancouver	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(4): 308 - 314.
IEEE	Topçu S,ÖZHAN B,Alkan A,AKYOL M,ŞİMŞEK ORHON F,BAŞKAN S,Ulukol B,BERBEROĞLU M,siklar z,TUFAN ŞATIROĞLU N,TUFAN A "Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children." Journal of Clinical Research in Pediatric Endocrinology, 9, ss.308 - 314, 2017.
ISNAD	Topçu, Seda vd. "Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children". Journal of Clinical Research in Pediatric Endocrinology 9/4 (2017), 308-314.