Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi
Yıl: 2018 Cilt: 27 Sayı: 4 Sayfa Aralığı: 319 - 322 Metin Dili: Türkçe İndeks Tarihi: 15-05-2019
Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi
Öz: Amaç: Yaşa bağlı makula dejenerasyonu(YBMD) olan hastalarda serum vitamin D düzeyini araştırmaktır.Gereç ve yöntemler: YBMD tanısıyla takip edilen 26 kuru tip,25 yaş tip toplam 51 YMBD hastası ile benzer yaş ve cinsiyetteki 34sağlıklı kontrol çalışma kapsamında değerlendirildi. Tüm katılımcıların serum vitamin D düzeyleri ölçüldü. Vitamin D düzeyleri ara-sındaki karşılaştırmaları t testi ile yapıldı.Bulgular: Kuru tip YBMD’li hastalarda serum vitamin D düzeyi ortalamaları21,40±12,61μg/L, yaş tip YBMD’de 21,25±15,19μg/L,kontrol grubunda ise 24,84±12,9 μg/L olarak bulundu. Hem kuru tip, hem de yaş tip YMBD hastaları ile kontroller arasında serumvitamin D seviyeleri açısından anlamlı bir farklılık tespit edilmedi (sırasıyla p=0,307, p=0,332).Sonuç: YBMD hastalarında serum vitamin D düzeyinde istatistiksel olarak anlamlı bir değişiklik saptanmadı.
Anahtar Kelime: Serum Vitamin D Levels in Patients with Age Related Macula Degeneration
Öz: Purpose: To investigate vitamin D levels in patients with age related macula degeneration (AMD). Materials and Methods: 26 dry AMD and 25 wet AMD totally 21 patients with AMD follow-up and age-gender matched 34 healthy control were included in the study. Vitamin D levels of all participants were measured. Comparisons among Vitamin D levels were performed by paired t test. Results: Mean vitamin D levels were found to be 21, 40±12, 61μg/L in dry AMD patients, 21, 25±15, 19μg/L in wet AMD patients and 24, 84±12, 9 μg/L in control group. When compared to control group, mean vitamin D levels were not found to be signifi cantly different from both dry AMD and wet AMD patients. (p=0,307, p=0,332 respectively) Conclusion: In AMD patients serum vitamin D levels were not found to be statistically signifi cantly different.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
- Klein R, Chou CF, Klein BE, et al. Prevalence of age-related macu- lar degeneration in the US population. Arch Ophthalmol 2011;129: 75-80
- Owen CG, Fletcher AE, Donoghue M, et al. How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom. Br J Ophthalmol 2003;87: 312-7
- Woo JH, Sanjay S, AuEong KG, The epidemiology of age-related Macular degeneration in the Indian subcontinent. Acta Ophthal- mol 2009; 87: 262-9
- Kawasaki R, Yasuda M, Song SJ, et al. The prevalence of age-re- lated macular degeneration in Asians: A systematic review and meta-analysis. Ophthalmology 2010;117: 921-7
- Yazar Z, Zırığ HA. Kuru tip yaşa bağlı makula dejeneresansı teda- visi. Ret-Vit 2010;18:253-62
- Singh A, Falk MK, Subhi Y, et al. The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular dege- neration: a cross-sectional study.PLoS One. 2013;29;8(7):e70948
- Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010; 95:471–8
- Hewison M. Vitamin D and the immunesystem: new perspectives on an old the me. Endocrinol Metab Clin North Am 2010; 39:365– 79
- Krishnan AV, Feldman D. Mechanisms of the anti-cancer and an- ti-infl ammatory actions of vitamin D. Annu Rev Pharmacol Toxi- col 2011; 51:311–36
- Lee V, Rekhi E, Hoh Kam J. et al. Vitamin D rejuvenates aging eyes by reducing infl ammation, clearing amyloid beta and impro- ving visual function. Neurobiol Aging 2012; 33:2382–9
- Mora JR, Iwata M, vonAndrian UH. Vitamin effects on the immu- ne system: Vitamins A and D take centre stage. Nat Rev Immunol 2008; 8:685–98
- Shokravi MT, Marcus DM, Alroy J, et al. Vitamin D inhibits angi- ogenesis in trans genic murine retinoblastoma. Invest Ophthalmol Vis Sci 1995; 36: 83–7.
- Shen CL, Samathanam C, Graham S et al. Green tea polyphe- nols and 1-alpha-OH-vitamin D(3) attenuate chronic infl ammati- on-induced myocardial fi brosis in female rats. J Med Food 2012; 15:269–77
- Iseki K, Tatsuta M, Uehara H, et al. Inhibition of angiogenesis as a mechanism for inhibition by 1 alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcino genesis induced by azoxymethane in Wistar rats. Int J Cancer 1999;81: 730–3.
- Lin AM, Chen KB, Chao PL. Anti oxidative effect of vitamin D3 on zinc induced oxidative stress in CNS. Ann N Y Acad Sci 2005;1053: 319–29
- Alsalem JA, Patel D, Susarla R, et al. Characterization of vitamin D production by human ocular barrier cells. Invest Ophthalmol Vis Sci. 2014; 55(4):2140–7
- Bird AC, Bressler NM, Bressler SB, et al. An international classifi - cation and grading system for age-related maculopathy and age-re- lated macular degeneration. International ARM Epidemiological Study Group. Surv Ophthalmol 1995;39(5):367-74
- Day S, Acquah K, Platt A, et al. Association of vitamin D defi cien- cy and age-related macular degeneration in medicare benefi ciaries. Arch Ophthalmol 2012;130:1070-1
- Golan S, Shalev V, Treister G, et al. Reconsidering the connection between vitamin D levels and age-related macular degeneration. Eye (Lond) 2011;25:1122-9
- Millen AE, Nie J, Sahli MW, et al. Vitamin D Status and pPreva- lent Early Age-Related Macular Degeneration in African Ameri- cans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study. J Nutr Health Aging 2017;21(7):772-80
- Parekh N, Chappell RJ, Millen AE, et al. Association between vi- tamin D and age-related macular degeneration in the Third Natio- nal Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol 2007;125:661-9
- Graffe A, Milea D, Annweiler C, et al. Association between hypo- vitaminosis D and latest ages of age-related macular degeneration: a case-controlstudy. J Am Geriatr Soc 2012; 60:1367–9
- McKay GJ, Young IS, McGinty A, et al. Associations between Se- rum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. Ophthalmology 2017;124(1):90-6
- Cougnard-Grégoire A, Merle BM, Korobelnik JF, et al. Vitamin D defi ciency in community-dwelling elderly is not associated with Age-Related Macular Degeneration J Nutr 2015 g;145(8):1865-72
- Itty S, Day S, Lyles KW, et al. Vitamin D defi ciency in neovascular versus nonneovascular age related macular degeneration. Retina 2014;34:1779-86
- Millen AE, Voland R, Sondel SA et al. Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol 2011;129:481-9
- Kim EC, Han K, Jee D. Inverse relationship between high blood 25-hydroxyvitamin D and latest age of age-related macular dege- neration in a representative Korean population. Invest Ophthalmol Vis Sci 2014;55:4823-31
- Grant WB, Strange RC, Garland CF. Sunshine is good medicine. The health benefi tcs of ultraviolet-B induced vitamin D producti- on. J Cosmet dermatol 2003;2(2):86-98
| APA | kocamis o, KILIÇ R, POLAT O, Kurt A (2018). Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. , 319 - 322. |
| Chicago | kocamis ozkan,KILIÇ Raşit,POLAT Osman Ahmet,Kurt Ali Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. (2018): 319 - 322. |
| MLA | kocamis ozkan,KILIÇ Raşit,POLAT Osman Ahmet,Kurt Ali Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. , 2018, ss.319 - 322. |
| AMA | kocamis o,KILIÇ R,POLAT O,Kurt A Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. . 2018; 319 - 322. |
| Vancouver | kocamis o,KILIÇ R,POLAT O,Kurt A Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. . 2018; 319 - 322. |
| IEEE | kocamis o,KILIÇ R,POLAT O,Kurt A "Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi." , ss.319 - 322, 2018. |
| ISNAD | kocamis, ozkan vd. "Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi". (2018), 319-322. |
| APA | kocamis o, KILIÇ R, POLAT O, Kurt A (2018). Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. Retina-Vitreus, 27(4), 319 - 322. |
| Chicago | kocamis ozkan,KILIÇ Raşit,POLAT Osman Ahmet,Kurt Ali Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. Retina-Vitreus 27, no.4 (2018): 319 - 322. |
| MLA | kocamis ozkan,KILIÇ Raşit,POLAT Osman Ahmet,Kurt Ali Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. Retina-Vitreus, vol.27, no.4, 2018, ss.319 - 322. |
| AMA | kocamis o,KILIÇ R,POLAT O,Kurt A Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. Retina-Vitreus. 2018; 27(4): 319 - 322. |
| Vancouver | kocamis o,KILIÇ R,POLAT O,Kurt A Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi. Retina-Vitreus. 2018; 27(4): 319 - 322. |
| IEEE | kocamis o,KILIÇ R,POLAT O,Kurt A "Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi." Retina-Vitreus, 27, ss.319 - 322, 2018. |
| ISNAD | kocamis, ozkan vd. "Yaşa Bağlı Makula Dejenerasyonlu Hastalarda Serum Vitamin D Düzeyi". Retina-Vitreus 27/4 (2018), 319-322. |
