Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?
Yıl: 2018 Cilt: 27 Sayı: 4 Sayfa Aralığı: 340 - 343 Metin Dili: İngilizce İndeks Tarihi: 15-05-2019
Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?
Öz: Purpose: We aimed to compare serum endocan levels in branch retinal vein occlusion (BRVO) patients and control subjects.Material and Methods: This study was conducted on 33 BRVO patients and 32 control subjects as a cross-sectional case control study.Serum endocan levels were measured using an enzyme-linked immunosorbent assay.Results: The mean age, gender distribution and body mass index were similar in the two groups with no signifi cant difference (p>0.05).Serum endocan levels were 34.11±11.33 ng/mL in the BRVO patients and 32.34±8.86 ng/mL in the control group (p=0.487).Conclusions: Increased serum endocan levels were found in BRVO patients comparing controls subjects, however, the differencewas not statistically signifi cant. Further studies evaluating vitreous and/or humor aqueous endocan levels are needed to clarify thepathophysiological role of endocan in BRVO pathogenesis.
Anahtar Kelime: Konular:
Retinal Ven Dal Tıkanıklığında Serum Endokan Seviyeleri Önemli mi?
Öz: Amaç: Retinal ven dal tıkanıklığı (RVDT) hastaları ve kontrol grubu bireylerin serum endokan seviyelerini karşılaştırmayı amaçladık. Gereç ve Yöntemler: Bu çalışma 33 RVDT hastası ve 32 kontrol olgusu içeren kesitsel bir vaka kontrol çalışması olarak planlanmıştır. Serum endokan seviyeleri, bir enzime bağlı immünosorbent assay (ELİSA) kullanılarak ölçüldü. Bulgular: İki grup arasında yaş ortalamaları, cinsiyet dağılımı ve vücut kitle indeksi açısından anlamlı fark yoktu (p>0.05). RVDT hastalarında serum endokan düzeylerinin ortalaması 34.11 ± 11.33 ng / mL olarak saptanırken kontrol grubunda 32.34 ± 8.86 ng / mL idi (p = 0.487). Sonuç: İstatistiksel düzeyde anlamlı olmasa da RVDT hastalarında serum endokan seviyesi kontrol grubuna göre daha yüksek olarak bulunmuştur. RVDT patogenezinde endokanın patofi zyolojik rolünü araştırmak için vitreus ve/veya aköz hümör endokan düzeylerini de değerlendiren daha ileri çalışmalara ihtiyaç vardır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
- Adenuga OO, Ramyil AV, Odugbo OP, et al. Prevalence, Pattern and Risk Factors for Retinal Vascular Occlusions in a Tertiary Hospital in Jos, Nigeria. Niger J Med 2015;24(4):331-6
- Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. J Ophthalmol 2014;2014:724780
- Hayreh SS, Zimmerman MB, Podhajsky P. Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. American Journal of Ophthalmology 1994;117(4):429-41
- Feng J, Zhao T, Zhang Y, et al. Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion. PLoS One 2013;8(7):e68149
- Koss MJ, Pfi ster M, Rothweiler F, et al. Comparison of cytokine levels from undiluted vitreous of untreated patients with retinal vein occlusion. Acta Ophthalmol 2012;90(2):e98-e103
- Michalska-Małecka K, Gaborek A, Nowak M, et al. Evaluation of the effectiveness and safety of glucocorticoids intravitreal implant therapy in macular edema due to retinal vein occlusion. Clin Interv Aging 2016;11:699-705
- Yang J, Yang Q, Yu S, et al. Endocan: A new marker for cancer and a target for cancer therapy. Biomed Rep 2015;3(3):279-83
- Kali A, Shetty KS. Endocan: A novel circulating proteoglycan. Indian J Pharmacol 2014;46(6):579-83
- Ehlers JP, Fekrat S. Retinal vein occlusion: beyond the acute event. Surv Ophthalmol 2011;56(4):281-99
- Fiebai B, Ejimadu CS, Komolafe RD. Incidence and risk factors for retinal vein occlusion at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. Niger J Clin Pract 2014;17(4):462-6
- Bringmann A, Reichenbach A, Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res 2004;36(5):241-9
- Fujimoto T, Inoue T, Maki K, et al. Vascular endothelial growth Factor-A Increases the aqueous humor outfl ow facility. PLoS One 2016;11(9):e0161332
- Balta S, Mikhailidis DP, Demirkol S, et al. Endocan: A novel infl ammatory indicator in cardiovascular disease? Atherosclerosis 2015;243(1):339-43
- Sarrazin S, Adam E, Lyon M, et al. Endocan or endothelial cell specifi c molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy. Biochim Biophys Acta 2006;1765(1):25-37
- Bechard D, Meignin V, Scherpereel A, et al. Characterization of the secreted form of endothelial-cell-specifi c molecule 1 by specifi c monoclonal antibodies. J Vasc Res 2000;37(5):417-25
- Zhang SM, Zuo L, Zhou Q, et al. Expression and distribution of endocan in human tissues. Biotech Histochem 2012;87(3):172-8
- Shin JW, Huggenberger R, Detmar M. Transcriptional profi ling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specifi c molecule-1 as a novel mediator of lymphangiogenesis. Blood 2008;112(6):2318-26
- Cox LA, van Eijk LT, Ramakers BP, et al. Infl ammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo. Shock 2015;43(4):322-6
- Scherpereel A, Depontieu F, Grigoriu B, et al. Endocan, a new endothelial marker in human sepsis. Crit Care Med 2006;34(2):532- 7
- Mihajlovic DM, Lendak DF, Brkic SV, et al. Endocan is useful biomarker of survival and severity in sepsis. Microvasc Res 2014;93:92-7
- Grigoriu BD, Depontieu F, Scherpereel A, et al. Endocan expression and relationship with survival in human non-small cell lung cancer. Clin Cancer Res 2006;12(15):4575-82
- Balta I, Balta S, Koryurek OM, et al. Serum endocan levels as a marker of disease activity in patients with Behçet disease. J Am Acad Dermatol 2014;70(2):291-6
- Hoeben A, Landuyt B, Highley MS, et al. Vascular endothelial growth factor and angiogenesis. Pharmacological Reviews 2004;56(4):549-80
- Abu El-Asrar AM, Nawaz MI, De Hertogh G, et al. The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor. Curr Eye Res 2015;40(3):321-31
- Wallsh J, Sharareh B, Gallemore R. Therapeutic effect of dexamethasone implant in retinal vein occlusions resistant to anti-VEGF therapy. Clinical Ophthalmology (Auckland, NZ) 2016;10:947-54
| APA | Kurt A, KILIÇ R, nar r, kocamis o, POLAT O (2018). Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. , 340 - 343. |
| Chicago | Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan,POLAT Osman Ahmet Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. (2018): 340 - 343. |
| MLA | Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan,POLAT Osman Ahmet Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. , 2018, ss.340 - 343. |
| AMA | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. . 2018; 340 - 343. |
| Vancouver | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. . 2018; 340 - 343. |
| IEEE | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O "Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?." , ss.340 - 343, 2018. |
| ISNAD | Kurt, Ali vd. "Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?". (2018), 340-343. |
| APA | Kurt A, KILIÇ R, nar r, kocamis o, POLAT O (2018). Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. Retina-Vitreus, 27(4), 340 - 343. |
| Chicago | Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan,POLAT Osman Ahmet Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. Retina-Vitreus 27, no.4 (2018): 340 - 343. |
| MLA | Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan,POLAT Osman Ahmet Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. Retina-Vitreus, vol.27, no.4, 2018, ss.340 - 343. |
| AMA | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. Retina-Vitreus. 2018; 27(4): 340 - 343. |
| Vancouver | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?. Retina-Vitreus. 2018; 27(4): 340 - 343. |
| IEEE | Kurt A,KILIÇ R,nar r,kocamis o,POLAT O "Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?." Retina-Vitreus, 27, ss.340 - 343, 2018. |
| ISNAD | Kurt, Ali vd. "Is Serum Endocan Levels Important in Branch Retinal Vein Occlusion?". Retina-Vitreus 27/4 (2018), 340-343. |
