Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group
Yıl: 2018 Cilt: 35 Sayı: 1 Sayfa Aralığı: 21 - 28 Metin Dili: İngilizce DOI: 10.5152/NSN.2018.10247 İndeks Tarihi: 15-05-2019
Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group
Öz: Objective: This study aimed to evaluate laboratory oligoclonal band (OCB) patterns together with related IgG results andcompare these results with data obtained through final clinical diagnosis. Also, to evaluate electrophoretic patterns based onreibergrams and the diagnostic value of OCBs in patients with multiple sclerosis (MS).Methods: Patients were grouped based on their diagnosis. Six classic patterns were determined. Oligoclonal band patternsand related IgG results were evaluated and these results were later compared with final clinical diagnoses.Results: A total of 1022 patients with known diagnoses were studied. Electrophoretic patterns and band counting based onReibergram depictions were significantly different among patients with MS and other neurologic diseases. For all patients withMS, the OCB band positivity rate was 82.4%. Additionally, in the MS group, a significantly higher percentage (36.60%) of OCBpositivity with more than 10 bands was detected. When reibergram results in the intrathecal IgG synthesis area and OCB counts(>10) were evaluated together, the diagnostic sensitivity (37%) and specificity (95%) were increased.Conclusion: OCB positivity, band counts, and Reibergram depictions contribute further to the diagnosis of ms when per-formed together for the neurologic diseases spectrum. OCB count, IgG index values, and Reibergram depictions should all beincluded in cerebrospinal fluid electrophoresis reports. The combined use of several laboratory test results are expected toprovide valuable input for differential diagnosis of neurologic diseases.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | PINAR A, TUNCER KURNE A, LAY İ, ACAR ÖZEN N, Karahan S, KARABUDAK R, Akbıyık F (2018). Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. , 21 - 28. 10.5152/NSN.2018.10247 |
| Chicago | PINAR Aslı,TUNCER KURNE Aslı,LAY İNCİLAY,ACAR ÖZEN NAZİRE PINAR,Karahan Sevilay,KARABUDAK Rana,Akbıyık Filiz Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. (2018): 21 - 28. 10.5152/NSN.2018.10247 |
| MLA | PINAR Aslı,TUNCER KURNE Aslı,LAY İNCİLAY,ACAR ÖZEN NAZİRE PINAR,Karahan Sevilay,KARABUDAK Rana,Akbıyık Filiz Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. , 2018, ss.21 - 28. 10.5152/NSN.2018.10247 |
| AMA | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. . 2018; 21 - 28. 10.5152/NSN.2018.10247 |
| Vancouver | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. . 2018; 21 - 28. 10.5152/NSN.2018.10247 |
| IEEE | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F "Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group." , ss.21 - 28, 2018. 10.5152/NSN.2018.10247 |
| ISNAD | PINAR, Aslı vd. "Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group". (2018), 21-28. https://doi.org/10.5152/NSN.2018.10247 |
| APA | PINAR A, TUNCER KURNE A, LAY İ, ACAR ÖZEN N, Karahan S, KARABUDAK R, Akbıyık F (2018). Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. Neurological sciences and neurophysiology (Online), 35(1), 21 - 28. 10.5152/NSN.2018.10247 |
| Chicago | PINAR Aslı,TUNCER KURNE Aslı,LAY İNCİLAY,ACAR ÖZEN NAZİRE PINAR,Karahan Sevilay,KARABUDAK Rana,Akbıyık Filiz Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. Neurological sciences and neurophysiology (Online) 35, no.1 (2018): 21 - 28. 10.5152/NSN.2018.10247 |
| MLA | PINAR Aslı,TUNCER KURNE Aslı,LAY İNCİLAY,ACAR ÖZEN NAZİRE PINAR,Karahan Sevilay,KARABUDAK Rana,Akbıyık Filiz Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. Neurological sciences and neurophysiology (Online), vol.35, no.1, 2018, ss.21 - 28. 10.5152/NSN.2018.10247 |
| AMA | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. Neurological sciences and neurophysiology (Online). 2018; 35(1): 21 - 28. 10.5152/NSN.2018.10247 |
| Vancouver | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group. Neurological sciences and neurophysiology (Online). 2018; 35(1): 21 - 28. 10.5152/NSN.2018.10247 |
| IEEE | PINAR A,TUNCER KURNE A,LAY İ,ACAR ÖZEN N,Karahan S,KARABUDAK R,Akbıyık F "Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group." Neurological sciences and neurophysiology (Online), 35, ss.21 - 28, 2018. 10.5152/NSN.2018.10247 |
| ISNAD | PINAR, Aslı vd. "Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a wide patient group". Neurological sciences and neurophysiology (Online) 35/1 (2018), 21-28. https://doi.org/10.5152/NSN.2018.10247 |
