The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels

KISAÇAM, Mehmet Ali; TURKER, FEVZI SARPER; OZAN, Sema TEMİZER; OZAN KOCAMÜFTÜOĞLU, GONCA; dogan, ayse

The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels

Ayşe DOĞAN, (Bitlis Eren Üniversitesi, Sağlık Yüksek Okulu ,Fizik Tedavi ve Rehabilitasyon Bölümü, Bitlis, Türkiye)

Sema TEMİZER OZAN, (Bitlis Eren Üniversitesi, Sağlık Yüksek Okulu ,Fizik Tedavi ve Rehabilitasyon Bölümü, Bitlis, Türkiye)

Mehmet Ali KISAÇAM, (Fırat Üniversitesi Veteriner Fakültesi Biyokimya Anabilim Dalı, Elazığ, Türkiye)

GONCA OZAN KOCAMÜFTÜOĞLU, (Fırat Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Elazığ, Türkiye)

Fevzi Sarper TÜRKER (Elazığ Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Elazığ, Türkiye)

Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi

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Yıl: 2018 Cilt: 32 Sayı: 1 Sayfa Aralığı: 41 - 45 Metin Dili: İngilizce İndeks Tarihi: 27-05-2019

The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels

Öz:

Objective: The aim of the study was to assess the endothelial function with arginase activity and nitric oxide (NO) levels in patients undergoing coronary artery bypass grafting (CABG) surgery.Materials and Methods: The study was conducted on 26 patients undergoing CABG surgery. Blood samples were collected from the patients in the preoperative, peroperative, and postoperative periods. Arginase activity and NO levels were measured spectrophotometrically from the collected samples.Results: Arginase activity decreased significantly in patients in the peroperative period compared to the preoperative period. There was no significance in terms of arginase activity in the postoperative period compared to the preoperative and peroperative periods. On the other hand, NO levels increased significantly in patients in the peroperative period. There was no significant increase in terms of NO level in the postoperative period; whereas, there was an insignificant increase compared to the preoperative period.Conclusion: Complications that may occur after the bypass surgery can be avoided by determining the treatment methods that will prevent the decrease in NO level and the increase in arginase enzyme activity occurring as a result of the bypass surgery and it can be ensured these patients to have a more enhanced quality of life and to be healthy after the surgery.

Anahtar Kelime:

Konular: Cerrahi

Kardiyopulmoner Bypass Cerrahisinin Arginaz Aktivitesi ve Nitrik Oksit Seviyeleri Üzerine Etkisi

Öz:

Amaç: Çalışmanın amacı, koroner arter bypass greftleme (CABG) cerrahisi uygulanan hastalarda, arginaz aktivitesi ve nitrik oksit (NO) düzeyleri ile endotel fonksiyonlarını değerlendirmektir. Gereç ve Yöntem: Çalışmada, CABG ameliyatı geçiren 26 hasta yer aldı. Hastalardan preoperatif, peroperatif ve postoperatif dönemlerde kan örnekleri alındı. Alınan kan örneklerinde arginaz aktivitesi ve NO seviyeleri spektrofotometrik olarak ölçüldü. Bulgular: Arginaz aktivitesi, peroperatif dönemdeki hastalarda preoperatif döneme göre anlamlı olarak azaldı. Postoperatif dönemde arginaz aktivitesi bakımından preoperatif ve peroperatif dönemlere göre anlamlı bir fark tespit edilmedi. Ayrıca, peroperatif dönemdeki hastalarda NO düzeyleri anlamlı bir şekilde arttığı belirlendi. Postoperatif dönemde ise NO düzeyinde istatistiksel olarak anlamlı bir artış olmamasına rağmen, preoperatif döneme göre artış beirlendi. Sonuç: Bypass cerrahisinden sonra meydana gelebilecek komplikasyonlar, bypass ameliyatı sonucunda ortaya çıkan NO düzeyinde azalmayı ve arginaz enzim aktivitesindeki artışı engelleyecek tedavi yöntemlerinin belirlenmesi ile önlenebilir ve bu hastaların operasyon sonrası daha kaliteli ve sağlıklı bir hayat yaşamaları sağlanabilir.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	dogan a, OZAN S, KISAÇAM M, OZAN KOCAMÜFTÜOĞLU G, TURKER F (2018). The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. , 41 - 45.
Chicago	dogan ayse,OZAN Sema TEMİZER,KISAÇAM Mehmet Ali,OZAN KOCAMÜFTÜOĞLU GONCA,TURKER FEVZI SARPER The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. (2018): 41 - 45.
MLA	dogan ayse,OZAN Sema TEMİZER,KISAÇAM Mehmet Ali,OZAN KOCAMÜFTÜOĞLU GONCA,TURKER FEVZI SARPER The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. , 2018, ss.41 - 45.
AMA	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. . 2018; 41 - 45.
Vancouver	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. . 2018; 41 - 45.
IEEE	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F "The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels." , ss.41 - 45, 2018.
ISNAD	dogan, ayse vd. "The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels". (2018), 41-45.

APA	dogan a, OZAN S, KISAÇAM M, OZAN KOCAMÜFTÜOĞLU G, TURKER F (2018). The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, 32(1), 41 - 45.
Chicago	dogan ayse,OZAN Sema TEMİZER,KISAÇAM Mehmet Ali,OZAN KOCAMÜFTÜOĞLU GONCA,TURKER FEVZI SARPER The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 32, no.1 (2018): 41 - 45.
MLA	dogan ayse,OZAN Sema TEMİZER,KISAÇAM Mehmet Ali,OZAN KOCAMÜFTÜOĞLU GONCA,TURKER FEVZI SARPER The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, vol.32, no.1, 2018, ss.41 - 45.
AMA	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi. 2018; 32(1): 41 - 45.
Vancouver	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi. 2018; 32(1): 41 - 45.
IEEE	dogan a,OZAN S,KISAÇAM M,OZAN KOCAMÜFTÜOĞLU G,TURKER F "The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels." Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, 32, ss.41 - 45, 2018.
ISNAD	dogan, ayse vd. "The Effect of Cardiopulmonary Bypass Surgery on Arginase Activity and Nitric Oxide Levels". Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 32/1 (2018), 41-45.