Objective: There is’nt any study giving information about profiles of upper gastroin-testinal (GI) diseases in Somalia; this study has reported the analysis of upper endoscopic resultsfrom Mogadishu for the first time. In this study we aimed to evaluate the distributions of the uppergastrointestinal diseases in Mogadishu. Material and Methods: Three hundred six patients who un-derwent upper GI endoscopy between 01.01.2015 and 20.04.2017 at Mogadishu Recep Tayyip Er-doğan Somalia-Turkey Training and Research Hospital were included in this study. Patientsgrouped according to the age, gender and diagnoses and assessed. Results: Ninety-seven patientswere female (31.7%), 209 patients were male (68.3%). Age range was 16-97 years (mean age 47.9years). The rates of upper GI were 18.0% (55 cases) esophageal cancer (nearly all patients had ade-nocarcinoma, squamous type was very rare), 2.3% (7 cases) gastric adenocarcinoma, 44.1% (135) en-doscopic gastritis, 10.1% (31cases) peptic esophagitis, 4.3% (13 cases) duodenal ulcer, 4.3% (13 cases)bulbitis, 3.0% (9 cases) hiatal hernia, and 1.3% (4 cases) candidial esophagitis. 24 patients (7.8%) hadnormal endoscopic appearance. C o n c l u s i o n : In our study we showed that the prevalence of esopha-gial cancer was higher in Mogadishu than in those of western countries. We think that the high rateof esophagus cancers due to the use of “khat” named an anxiolytic plant, too hot rice eating, poornutrition from fresh vegetables and fruits, and the meals cooked in coal fire. Reduction the khatchewing and the improvements in eating habits are mandatory in order to reduce esophageal can-cer cases.