Maede SALEHİ
(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
Majid SAEEDİ
(Department of Pharmaceutices, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran)
Anahita GHORBANİ
(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
Parisa GHODRATİ
(Dentist, Ghazvin, Iran)
Mahmoud MOOSAZADEH
(Health Science Research Center,Addiction Institude, Mazandaran University of Medical Sciences, Sari, Iran)
Sohrab ROSTAMKALAEİ
(Department of Pharmaceutices,Faculty of Pha rmacy, Mazandaran University of Medical Sciences, Sari, Iran)
Mahdi Babaei HATKEHLOUEİ
(Student of Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
Tahereh MOLANİA
(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
Yıl: 2018Cilt: 29Sayı: 3ISSN: 1300-056X / 2147-2092Sayfa Aralığı: 196 - 201İngilizce

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The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy
Background: Oral mucositis is defined as oral mucosal inflammation in cancerpatients that is caused by chemotherapy and/or radiotherapy. Propolis is anatural product produced by bees and has antimicrobial, antioxidant, and antiinflammatoryeffects. Therefore, considering the anti-inflammatory propertiesof Propolis, the aim of this study is to evaluate the efficacy of Propolis tablet onoral mucositis caused by chemotherapy.Materials and Methods: In this randomized, double-blinded, placebo-controlledstudy, 50 patients were enrolled in the study, and samples were taken frompatients on Folfox chemotherapy regimen with colon cancer who were admittedto the Oncology Center of Imam Khomeini Hospital in Sari. The patients werethen divided into two groups of 25. The first group received 50 mg Propolistablets as 2 tablets per day for 21 days and the second group received placebo.All patients were examined by oral medicine specialist after initial examination,weekly and for 3 weeks, and the severity of mucositis was recorded according toWHO criteria. Data analysis was performed in SPSS ver. 22 software using T testand Mann-Whitney and Kruskal-Wallis tests.Results: The age range of the participants in the study was between 26-72 years.In the intervention group 13 women (52%) and 12 men (48%) and in the controlgroup 13 women (52%) and 12 men (48%) participated .In this study, there wasa significant difference in the mean of oral mucositis severity in the Propolisgroup compared to placebo group. In the intervention group, oral mucositisgrade was significantly lower in the 2nd and 3rd follow up sessions than in theplacebo group (p <0.05). No negative complications were reported by patients.Conclusion: This clinical trial study showed that Propolis tablet could play animportant role in preventing and improving the oral mucositis caused bychemotherapy.
Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Alerji
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Anestezi
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Hematoloji
Fen > Tıp > İmmünoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Ortopedi
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Pediatri
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Fizyoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Psikiyatri
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Cerrahi
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Üroloji ve Nefroloji
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