The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy

SALEHİ ,Maede; SAEEDİ ,Majid; GHORBANİ ,Anahita; GHODRATİ ,Parisa; MOOSAZADEH ,Mahmoud; ROSTAMKALAEİ ,Sohrab; HATKEHLOUEİ ,Mahdi Babaei; MOLANİA ,Tahereh

doi:10.12996/gmj.2018.55

Maede SALEHİ

(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)

Majid SAEEDİ

(Department of Pharmaceutices, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran)

Anahita GHORBANİ

(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)

Parisa GHODRATİ

(Dentist, Ghazvin, Iran)

Mahmoud MOOSAZADEH

(Health Science Research Center,Addiction Institude, Mazandaran University of Medical Sciences, Sari, Iran)

Sohrab ROSTAMKALAEİ

(Department of Pharmaceutices,Faculty of Pha rmacy, Mazandaran University of Medical Sciences, Sari, Iran)

Mahdi Babaei HATKEHLOUEİ

(Student of Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)

Tahereh MOLANİA

(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)

Gazi Medical Journal

Yıl: 2018Cilt: 29Sayı: 3ISSN: 1300-056X / 2147-2092Sayfa Aralığı: 196 - 201Metin Dili: İngilizce

DOI: https://doi.org/10.12996/gmj.2018.55

221 5

İngilizce
Türkçe

The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy

Abstract: Background: Oral mucositis is defined as oral mucosal inflammation in cancerpatients that is caused by chemotherapy and/or radiotherapy. Propolis is anatural product produced by bees and has antimicrobial, antioxidant, and antiinflammatoryeffects. Therefore, considering the anti-inflammatory propertiesof Propolis, the aim of this study is to evaluate the efficacy of Propolis tablet onoral mucositis caused by chemotherapy.Materials and Methods: In this randomized, double-blinded, placebo-controlledstudy, 50 patients were enrolled in the study, and samples were taken frompatients on Folfox chemotherapy regimen with colon cancer who were admittedto the Oncology Center of Imam Khomeini Hospital in Sari. The patients werethen divided into two groups of 25. The first group received 50 mg Propolistablets as 2 tablets per day for 21 days and the second group received placebo.All patients were examined by oral medicine specialist after initial examination,weekly and for 3 weeks, and the severity of mucositis was recorded according toWHO criteria. Data analysis was performed in SPSS ver. 22 software using T testand Mann-Whitney and Kruskal-Wallis tests.Results: The age range of the participants in the study was between 26-72 years.In the intervention group 13 women (52%) and 12 men (48%) and in the controlgroup 13 women (52%) and 12 men (48%) participated .In this study, there wasa significant difference in the mean of oral mucositis severity in the Propolisgroup compared to placebo group. In the intervention group, oral mucositisgrade was significantly lower in the 2nd and 3rd follow up sessions than in theplacebo group (p <0.05). No negative complications were reported by patients.Conclusion: This clinical trial study showed that Propolis tablet could play animportant role in preventing and improving the oral mucositis caused bychemotherapy.

Keywords:

Subject Area: Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Alerji
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Anestezi
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Hematoloji
Fen > Tıp > İmmünoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Ortopedi
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Pediatri
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Fizyoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Psikiyatri
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Cerrahi
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Üroloji ve Nefroloji

Propolis Tabletinin Kemoterapiye Bağlı Gelişen Oral Mukozit Üzerine Etkisi

Öz:Amaç: Oral mukozit, kemoterapi ve/veya radyoterapinin neden olduğu kanser hastalarında oral mukozal inflamasyon olarak tanımlanır. Propolis, arılar tarafından üretilen ve antimikrobiyal, antioksidan ve anti-inflamatuar etkileri olan doğal bir üründür. Bu nedenle, Propolis'in antiinflamatuar özellikleri göz önüne alınarak, bu çalışmanın amacı, Propolis tabletinin kemoterapinin neden olduğu oral mukozit üzerindeki etkinliğini değerlendirmektir. Yöntem: Bu randomize, çift-kör, plasebo kontrollü çalışmada, 50 hasta çalışmaya alındı ve Sari'deki Imam Khomeini Hastanesi Onkoloji Merkezine başvuran kolon kanseri olup Folfox kemoterapi rejiminde olan hastalardan örnekler alındı. Hastalar daha sonra 25'er iki gruba ayrıldı. İlk grup 21 gün boyunca günde 2 tablet olarak 50 mg Propolis tableti aldı ve ikinci grup plasebo aldı. Tüm hastalar ilk muayeneden sonra, haftalık ve 3 hafta boyunca diş hekimi tarafından muayene edildi ve WHO kriterlerine göre mukozit şiddeti kaydedildi. Veri analizi, T testi, Mann-Whitney ve Kruskal-Wallis testleri kullanılarak SPSS ver.22 yazılım ile yapıldı. Bulgular: Çalışmaya katılanların yaş aralığı 26-72 yıl arasındaydı. Müdahale grubunda 13 kadın (% 52), 12 erkek (% 48) ve kontrol grubunda 13 kadın (% 52),12 erkek (% 48) bu çalışmaya katılmıştır. Propolis grubunda plasebo grubuna göre oral mukozit şiddeti açısından istatistiksel olarak anlam vardı. Girişim grubunda oral mukozit derecesi 2. ve 3. takip seanslarında plasebo grubuna göre anlamlı olarak düşüktü (p <0.05). Hastalar tarafından hiçbir olumsuz komplikasyon bildirilmedi. Sonuç: Bu klinik çalışma çalışması, Propolis tabletinin kemoterapinin neden olduğu oral mukozitin önlenmesinde faydalı ve önemli bir rol oynayabileceğini göstermiştir.

Anahtar Kelimeler:

Konu Alanı: SCIENCE > BASIC SCIENCES > BIOLOGY
SCIENCE > MEDICINE > ALLERGY
SCIENCE > MEDICINE > ANATOMY & MORPHOLOGY
SCIENCE > MEDICINE > ANDROLOGY
SCIENCE > MEDICINE > ANESTHESIOLOGY
SCIENCE > MEDICINE > Audiology & Speech-Language Pathology
SCIENCE > MEDICINE > BIOCHEMISTRY & MOLECULAR BIOLOGY
SCIENCE > MEDICINE > BIOPHYSICS
SCIENCE > MEDICINE > BIOTECHNOLOGY & APPLIED MICROBIOLOGY
SCIENCE > MEDICINE > CARDIAC & CARDIOVASCULAR SYSTEMS
SCIENCE > MEDICINE > CELL BIOLOGY
SCIENCE > MEDICINE > CLINICAL NEUROLOGY
SCIENCE > MEDICINE > CRITICAL CARE MEDICINE
SCIENCE > MEDICINE > DERMATOLOGY
SCIENCE > MEDICINE > EMERGENCY MEDICINE
SCIENCE > MEDICINE > ENDOCRINOLOGY & METABOLISM
SCIENCE > MEDICINE > GASTROENTEROLOGY & HEPATOLOGY
SCIENCE > MEDICINE > GERIATRICS & GERONTOLOGY
SCIENCE > MEDICINE > HEALTH CARE SCIENCES & SERVICES
SCIENCE > MEDICINE > HEMATOLOGY
SCIENCE > MEDICINE > IMMUNOLOGY
SCIENCE > MEDICINE > INFECTIOUS DISEASES
SCIENCE > MEDICINE > INTEGRATIVE & COMPLEMANTARY MEDICINE
SCIENCE > MEDICINE > MEDICAL ETHICS
SCIENCE > MEDICINE > MEDICAL INFORMATICS
SCIENCE > MEDICINE > MEDICAL LABORATORY TECHNOLOGY
SCIENCE > MEDICINE > MEDICINE, GENERAL & INTERNAL
SCIENCE > MEDICINE > MEDICINE, LEGAL
SCIENCE > MEDICINE > MEDICINE, RESEARCH & EXPERIMENTAL
SCIENCE > MEDICINE > MICROBIOLOGY
SCIENCE > MEDICINE > NEUROSCIENCES
SCIENCE > MEDICINE > OBSTETRICS & GYNECOLOGY
SCIENCE > MEDICINE > ONCOLOGY
SCIENCE > MEDICINE > OPHTHALMOLOGY
SCIENCE > MEDICINE > ORTHOPEDICS
SCIENCE > MEDICINE > OTORHINOLARYNGOLOGY
SCIENCE > MEDICINE > PATHOLOGY
SCIENCE > MEDICINE > PEDIATRICS
SCIENCE > MEDICINE > PERIPHERAL VASCULAR DISEASE
SCIENCE > MEDICINE > PHYSIOLOGY
SCIENCE > MEDICINE > PRIMARY HEALTH CARE
SCIENCE > MEDICINE > PSYCHIATRY
SCIENCE > MEDICINE > PUBLIC ENVIRONMENTAL & OCCUPATIONAL HEALTH
SCIENCE > MEDICINE > RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
SCIENCE > MEDICINE > REHABILITATION
SCIENCE > MEDICINE > RESPIRATORY SYSTEM
SCIENCE > MEDICINE > RHEUMATOLOGY
SCIENCE > MEDICINE > SPORT SCIENCES
SCIENCE > MEDICINE > SURGERY
SCIENCE > MEDICINE > TRANSPLANTATION
SCIENCE > MEDICINE > TROPICAL MEDICINE
SCIENCE > MEDICINE > UROLOGY & NEPHROLOGY

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