(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
(Department of Pharmaceutices, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran)
(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
(Dentist, Ghazvin, Iran)
(Health Science Research Center,Addiction Institude, Mazandaran University of Medical Sciences, Sari, Iran)
(Department of Pharmaceutices,Faculty of Pha rmacy, Mazandaran University of Medical Sciences, Sari, Iran)
(Student of Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
(Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran)
Yıl: 2018Cilt: 29Sayı: 3ISSN: 1300-056X / 2147-2092Sayfa Aralığı: 196 - 201İngilizce

221 5
The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy
Background: Oral mucositis is defined as oral mucosal inflammation in cancerpatients that is caused by chemotherapy and/or radiotherapy. Propolis is anatural product produced by bees and has antimicrobial, antioxidant, and antiinflammatoryeffects. Therefore, considering the anti-inflammatory propertiesof Propolis, the aim of this study is to evaluate the efficacy of Propolis tablet onoral mucositis caused by chemotherapy.Materials and Methods: In this randomized, double-blinded, placebo-controlledstudy, 50 patients were enrolled in the study, and samples were taken frompatients on Folfox chemotherapy regimen with colon cancer who were admittedto the Oncology Center of Imam Khomeini Hospital in Sari. The patients werethen divided into two groups of 25. The first group received 50 mg Propolistablets as 2 tablets per day for 21 days and the second group received placebo.All patients were examined by oral medicine specialist after initial examination,weekly and for 3 weeks, and the severity of mucositis was recorded according toWHO criteria. Data analysis was performed in SPSS ver. 22 software using T testand Mann-Whitney and Kruskal-Wallis tests.Results: The age range of the participants in the study was between 26-72 years.In the intervention group 13 women (52%) and 12 men (48%) and in the controlgroup 13 women (52%) and 12 men (48%) participated .In this study, there wasa significant difference in the mean of oral mucositis severity in the Propolisgroup compared to placebo group. In the intervention group, oral mucositisgrade was significantly lower in the 2nd and 3rd follow up sessions than in theplacebo group (p <0.05). No negative complications were reported by patients.Conclusion: This clinical trial study showed that Propolis tablet could play animportant role in preventing and improving the oral mucositis caused bychemotherapy.
Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Alerji
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Anestezi
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Hematoloji
Fen > Tıp > İmmünoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Ortopedi
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Pediatri
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Fizyoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Psikiyatri
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Cerrahi
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Üroloji ve Nefroloji
DergiAraştırma MakalesiErişime Açık
  • Tomaževič T, Jazbec J. A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complementary therapies in medicine. 2013;21:306-12.
  • Mamdoh J,Eman A.Evaluation of anti-inflammatory and antimicrobial effects of Iraqi propolis mouthwash in mucositis patients induced by chemotherapy. International Journal of Enhanced Research in SienceTechnology&Engineering. 2015;4:115.
  • Gonzalez-Barca E, Carratala J, Mykietiuk A, Fernandez-Sevilla A, Gudiol F. Predisposing factors and outcome of Staphylococcus aureus bacteremia in neutropenic patients with cancer. European Journal of Clinical Microbiology & Infectious Diseases. 2001;20:117-9.
  • Sonis ST. Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral oncology. 2009;45:1015-20.
  • RAS Noronha V, S Araujo G, T Gomes R, H Iwanaga S, C Barbosa M, N Abdo E, et al. Mucoadhesive propolis gel for prevention of radiation-induced oral mucositis. Current clinical pharmacology. 2014;9:359-64.
  • Turner L, Mupparapu M, Akintoye SO. Review of the complications associated with treatment of oropharyngeal cancer: a guide to the dental practitioner. Quintessence international (Berlin, Germany: 1985). 2013;44:267.
  • Satheeshkumar P, Chamba MS, Balan A, Sreelatha K, Bhatathiri V, Bose T. Effectiveness of triclosan in the management of radiation-induced oral mucositis: a randomized clinical trial. Journal of cancer research and therapeutics. 2010;6:466.
  • Parolia A, Thomas MS, Kundabala M, Mohan M. Propolis and its potential uses in oral health. International Journal of Medicine and Medical Science. 2010;2:210-5.
  • Nafiseh Saghafi؛ Zohre Yousofi؛ Fatemeh Homaei Shandiz؛ Monavar Afzal aghaee؛ Masoumeh Javedanmehr. Comparison of efficacy and side effects of propolis with chemotherapy and chemotherapy alone for neoadjuant therapy of ovarian cancer.IJOGI2015;18:1-5
  • Engelen MJ, Kos HE, Willemse PH, Aalders JG, de Vries EG, Schaapveld M, et al. Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma. Cancer. 2006;106(3):589-98.
  • Santos VR. Propolis: alternative medicine for the treatment of oral microbial diseases. Alternative Medicine: InTech; 2012;3:304
  • Farooqui T, Farooqui AA. Beneficial effects of propolis on human health and neurological diseases. Front Biosci (Elite Ed). 2012;4:779-93.
  • Özan F, Sümer Z, Polat ZA, Er K, Özan Ü, Deḡer O. Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. European journal of dentistry. 2007;1:195.
  • Sforcin J. Propolis and the immune system: a review. Journal of ethnopharmacology. 2007;113(1):1-14.
  • Kiderman A, Torten R, Furst A, Reinus K. Bi-lateral eosinophilic ulcers in an infant treated with propolis. Journal of dermatological treatment. 2001;12:29- 31.
  • Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clinical oral investigations. 2007;11(2):14.
  • Benguedouar L, Boussenane HN, Kebsa W, Alyane M, Rouibah H, Lahouel M. Efficiency of propolis extract against mitochondrial stress induced by antineoplasic agents (doxorubicin and vinblastin) in rats. 2008;10:17.
  • Bruschi M, Lara E, Martins C, Vinholis A, Casemiro L, Panzeri H, et al. Preparation and Antimicrobial Activityof Gelatin Microparticles Containing Propolis Against Oral Pathogens. Drug development and industrial pharmacy. 2006;32:229-38.
  • Ota C, Unterkircher C, Fantinato V, Shimizu M. Antifungal activity of propolis on different species of Candida. Mycoses. 2001;44:375-8.
  • Schnitzler P, Neuner A, Nolkemper S, Zundel C, Nowack H, Sensch KH, et al. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytotherapy Research. 2010;24:129.
  • Brown CG, Wingard J, editors. Clinical consequences of oral mucositis. Seminars in Oncology Nursing; 2004: Elsevier:116-91.
  • Carrega G, Castagnola E, Canessa A, Argenta P, Haupt R, Dini G, et al. Herpes simplex virus and oral mucositis in children with cancer. Supportive Care in Cancer. 1994;2:266-9.
  • Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, et al. Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. DARU Journal of Pharmaceutical Sciences. 2013;21:18.
  • Bolouri AJ, Pakfetrat A, Tonkaboni A, Aledavood SA, Najafi MF, Delavarian Z, et al. Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, PlaceboControlled Trial. Iranian journal of cancer prevention. 2015;8:94-105.
  • AkhavanKarbassi MH, Yazdi MF, Ahadian H, SadrAbad MJ. Randomized double-blind placebo-controlled trial of propolis for oral mucositis in patients receiving chemotherapy for head and neck cancer. Asian Pac J Cancer Prev. 2016;17:3611-4.
  • Little JW, Falace DA, Miller CS, Rhodus NL. Dental management of the medically compromised patient,7 th ed. 2008:448-76.
  • Chaveli-López B, Bagán-Sebastián JV. Treatment of oral mucositis due to chemotherapy. Journal of clinical and experimental dentistry. 2016;8:e201.
  • Zahmati AH, Alipoor R, Shahmirzadi AR, Khori V, Abolhasani MM. Chemical Decellularization Methods and Its Effects on Extracellular Matrix. Internal Medicine and Medical Investigation Journal. 2017;2:76-83.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.