Relationship of genetic factors with development of aortic dissection and aneurysm
Yıl: 2018 Cilt: 26 Sayı: 4 Sayfa Aralığı: 557 - 564 Metin Dili: İngilizce DOI: 10.5606/tgkdc.dergisi.2018.16424 İndeks Tarihi: 08-05-2019
Relationship of genetic factors with development of aortic dissection and aneurysm
Öz: Background: This study aims to investigate the relationshipbetween the development of aortic dissections and aneurysmswith the polymorphisms of angiotensin converting enzyme gene,methylenetetrahydrofolate reductase gene, plasminogen activatorinhibitor-1 gene, and nitric oxide synthase gene.Methods: Between April 2009 and July 2014, 38 patients with aorticdissections (28 males, 10 females; mean age 55.1±10.7 years; range,30 to 78 years) and 67 patients with aortic aneurysms (57 males,10 females; mean age 63.0±11.4 years; range, 31 to 82 years) wereincluded in this cross-sectional study. The control group consistedof 60 healthy volunteers (41 males, 19 females; mean age 56.3±11.2years; range, 30 to 82 years) without an aortic aneurysm ordissection, as assessed by thoracoabdominal computed tomography.The prespecified four genes were genotyped with competitive allelespecificpolymerase chain reaction.Results: The aortic dissection group had higher nitric oxidesynthase-3 (4b/4b) expression levels, compared to the control group.The aortic aneurysm group had also higher nitric oxide synthase-3(4b/4a) expression levels, compared to the control group. Comparedto the control group, a higher rate of angiotensin converting enzymeI/D gene polymorphism was detected in the aneurysm group, whilehigher D/D polymorphism rates were found in the dissection group;although not statistically significant.Conclusion: Our study results suggest that the nitric oxidesynthase-3 intron 4b/4b and nitric oxide synthase-3 intron 4b/4agene polymorphisms can be used as a predictor of aortic dissectionand aneurysm development.
Anahtar Kelime: Konular:
Aort anevrizması ve aort diseksiyonu gelişiminin genetik faktörler ile ilişkisi
Öz: Amaç: Bu çalışmada aort diseksiyonu ve anevrizma gelişimi ile anjiyotensin dönüştürücü enzim geni, metilentetrahidrofolat redüktaz geni, plazminojen aktivatör inhibitör-1 geni ve nitrik oksit sentaz geni polimorfizmleri arasındaki ilişki araştırıldı. Çalışma planı: Bu kesitsel çalışmaya Nisan 2009 - Temmuz 2014 tarihleri arasında aort diseksiyonu olan 38 hasta (28 erkek, 10 kadın; ort. yaş 55.1±10.7 yıl; dağılım 30-78 yıl) ve aort anevrizması olan 67 hasta (57 erkek,10 kadın; ort. yaş 63.0±11.4 yıl; dağılım 31-82 yıl) alındı. Kontrol grubu, torakoabdominal bilgisayarlı tomografi ile değerlendirildiği üzere, aort anevrizması veya diseksiyonu olmayan 60 sağlıklı gönüllüden (41 erkek, 19 kadın; ort. yaş 56.3±11.2 yıl; dağılım 30-82 yıl) oluşuyordu. Belirtilen dört genin, kompetitif allel spesifik-polimeraz zincir reaksiyonu ile genotiplemesi yapıldı. Bulgular: Kontrol grubuna kıyasla, aort diseksiyonu grubunda nitrik oksit sentaz-3 (4b/4b) ekspresyon düzeyi daha yüksekti. Kontrol grubuna kıyasla, aort anevrizması grubunda nitrik oksit sentaz-3 (4b/4a) ekspresyon düzeyi daha yüksekti. İstatistiksel olarak anlamlı olmamakla birlikte, kontrol grubuna kıyasla, anevrizma grubunda daha yüksek oranda anjiyotensin dönüştürücü enzim I/D gen polimorfizmi saptanır iken, diseksiyon grubunda daha yüksek D/D polimorfizm oranlarına rastlandı. Sonuç: Çalışma sonuçlarımız, nitrik oksit sentaz-3 intron 4b/4b ve nitrik oksit sentaz-3 intron 4b/4a gen polimorfizmlerinin, aort diseksiyonu ve anevrizma gelişiminin bir öngördürücüsü olarak kullanılabileceğini göstermektedir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Özmen R, TUNÇAY A, Sener E, EMİROĞULLARI Ö (2018). Relationship of genetic factors with development of aortic dissection and aneurysm. , 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| Chicago | Özmen Rıfat,TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Relationship of genetic factors with development of aortic dissection and aneurysm. (2018): 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| MLA | Özmen Rıfat,TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Relationship of genetic factors with development of aortic dissection and aneurysm. , 2018, ss.557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| AMA | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö Relationship of genetic factors with development of aortic dissection and aneurysm. . 2018; 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| Vancouver | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö Relationship of genetic factors with development of aortic dissection and aneurysm. . 2018; 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| IEEE | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö "Relationship of genetic factors with development of aortic dissection and aneurysm." , ss.557 - 564, 2018. 10.5606/tgkdc.dergisi.2018.16424 |
| ISNAD | Özmen, Rıfat vd. "Relationship of genetic factors with development of aortic dissection and aneurysm". (2018), 557-564. https://doi.org/10.5606/tgkdc.dergisi.2018.16424 |
| APA | Özmen R, TUNÇAY A, Sener E, EMİROĞULLARI Ö (2018). Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 26(4), 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| Chicago | Özmen Rıfat,TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi 26, no.4 (2018): 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| MLA | Özmen Rıfat,TUNÇAY AYDIN,Sener Elif Funda,EMİROĞULLARI Ömer Naci Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.26, no.4, 2018, ss.557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| AMA | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2018; 26(4): 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| Vancouver | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö Relationship of genetic factors with development of aortic dissection and aneurysm. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2018; 26(4): 557 - 564. 10.5606/tgkdc.dergisi.2018.16424 |
| IEEE | Özmen R,TUNÇAY A,Sener E,EMİROĞULLARI Ö "Relationship of genetic factors with development of aortic dissection and aneurysm." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 26, ss.557 - 564, 2018. 10.5606/tgkdc.dergisi.2018.16424 |
| ISNAD | Özmen, Rıfat vd. "Relationship of genetic factors with development of aortic dissection and aneurysm". Türk Göğüs Kalp Damar Cerrahisi Dergisi 26/4 (2018), 557-564. https://doi.org/10.5606/tgkdc.dergisi.2018.16424 |
