(Bülent Ecevit University Faculty of Medicine, Department of Anesthesiology and Reanimation, Zonguldak, Turkey)
(Bülent Ecevit University Faculty of Medicine, Department of Anesthesiology and Reanimation, Zonguldak, Turkey)
Yılmaz BAŞ
(Hitit University Faculty of Medicine, Department of Pathology, Çorum, Turkey)
(Bülent Ecevit University Faculty of Medicine, Department of General Surgery, Zonguldak, Turkey)
(Bülent Ecevit Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi, Bölümü, Zonguldak, Türkiye)
(Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Zonguldak, Türkiye)
Yıl: 2018Cilt: 56Sayı: 1ISSN: 1302-0072 / 2147-2688Sayfa Aralığı: 14 - 21İngilizce

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Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation
Aim: The aim of this study was to evaluate the protective use ofquercetin in a rat model of radiation-induced enteritis and colitis.Methods: Twenty four adult rats were randomly divided into fourgroups. Group SHAM was given only physiological saline, group QUERwas given quercetin 50 mg/kg for 15 days, group RAD was given onlyirradiation and group QUER+RAD was given quercetin 50 mg/kg, andthen irradiated. Twenty four hours after the exposure to radiation,all rats were euthanized for the evaluation of the ileum and colonmorphology and biochemical measurements.Results: Compared with the SHAM group, the serum malondialdehyde(MDA) level was significantly higher in group RAD (p=0.004) andwas significantly decreased in group QUER+RAD (p=0.015). TheMDA levels in the ileum and colon tissues were significantly higherin group RAD (p=0.004 and p=0.002, respectively), while treatmentwith quercetin significantly reduced lipid peroxidation in both tissuesin group QUER+RAD (p=0.015 and p=0.009, respectively). Comparedwith the control group, the serum total antioxidant status (TAS) levelwas significantly lower in Group RAD (p=0.002) and was significantlyincreased in group QUER+RAD (p=0.009). TAS in the ileum and colontissues were significantly lower in group RAD (p=0.002 and p=0.002)and were significantly higher in both tissues in group QUER+RAD(p=0.002 and p=0.002, respectively).Conclusion: This study confirmed that, in the model of radiationinducedileitis and colitis in rats, quercetin effectively decreased oxidativestress and inflammatory damage to both ileum and colon tissues.
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