Yıl: 2018 Cilt: 56 Sayı: 1 Sayfa Aralığı: 14 - 21 Metin Dili: İngilizce DOI: 10.4274/haseki.25743 İndeks Tarihi: 14-05-2019

Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation

Öz:
Aim: The aim of this study was to evaluate the protective use ofquercetin in a rat model of radiation-induced enteritis and colitis.Methods: Twenty four adult rats were randomly divided into fourgroups. Group SHAM was given only physiological saline, group QUERwas given quercetin 50 mg/kg for 15 days, group RAD was given onlyirradiation and group QUER+RAD was given quercetin 50 mg/kg, andthen irradiated. Twenty four hours after the exposure to radiation,all rats were euthanized for the evaluation of the ileum and colonmorphology and biochemical measurements.Results: Compared with the SHAM group, the serum malondialdehyde(MDA) level was significantly higher in group RAD (p=0.004) andwas significantly decreased in group QUER+RAD (p=0.015). TheMDA levels in the ileum and colon tissues were significantly higherin group RAD (p=0.004 and p=0.002, respectively), while treatmentwith quercetin significantly reduced lipid peroxidation in both tissuesin group QUER+RAD (p=0.015 and p=0.009, respectively). Comparedwith the control group, the serum total antioxidant status (TAS) levelwas significantly lower in Group RAD (p=0.002) and was significantlyincreased in group QUER+RAD (p=0.009). TAS in the ileum and colontissues were significantly lower in group RAD (p=0.002 and p=0.002)and were significantly higher in both tissues in group QUER+RAD(p=0.002 and p=0.002, respectively).Conclusion: This study confirmed that, in the model of radiationinducedileitis and colitis in rats, quercetin effectively decreased oxidativestress and inflammatory damage to both ileum and colon tissues.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Radyasyona Bağlı İntestinal Hasarda Quercetin’in Koruyucu Etkisi

Öz:
Amaç: Bu çalışmanın amacı rat modelinde radyasyona bağlı oluşan enterit ve kolit tedavisinde quercetin’in koruyucu rolünü değerlendirmektir. Yöntemler: Yirmi dört yetişkin rat randomize olarak dört gruba ayrıldı. Group SHAM’a sadece salin, grup QUER’e 15 gün boyunca 50 mg/ kg quercetin, grup RAD’a sadece radyasyon ve grup QUER+RAD’a 15 gün boyunca 50 mg/kg quercetin ardından radyasyon uygulandı. Radyasyon maruziyetinden 24 saat sonra ileum ve kolon morfolojisi ve biyokimyasal parametrelerin değerlendirilmesi için ratlara ötenazi uygulandı. Bulgular: SHAM grubuyla karşılaştırıldığında, serum malondialdehit (MDA) seviyesi grup RAD’da istatistiksel olarak anlamlı derecede yüksek (p=0,004) ve grup QUER+RAD’da düşük bulundu (p=0,015). İleum ve kolon dokularındaki MDA seviyesi grup RAD’da anlamlı olarak daha yüksek (sırasıyla; p=0,004 ve p=0,002) idi. Grup QUER+RAD’da ise her iki dokuda azalmış olarak bulundu (sırasıyla; p=0,015 ve p=0,009). Kontrol grubuyla karşılaştırıldığı zaman, serum total antioksidan kapasite (TAK) seviyesi grup RAD’da istatistiksel olarak anlamlı derecede düşük (p=0,002) ve grup QUER+RAD’da ise yüksek bulundu (p=0,009). İleum ve kolon dokularındaki TAK seviyesi grup RAD’da istatistiksel olarak anlamlı derecede düşük iken (sırasıyla; p=0,002 ve p=0,002), grup QUER+RAD’da ise her iki dokuda da anlamlı derecede yüksek bulundu (sırasıyla; p=0,002 ve p=0,002). Sonuç: Bu çalışma, ratlarda oluşturulan radyasyona bağlı ileit ve kolit modelinde quercetin’in, hem ileum hem de kolon dokularına oksidatif stres ve enflamatuvar hasarı etkili bir şekilde azalttığını doğrulamıştır.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA PİŞKİN Ö, KÖKSAL B, Baş Y, KARAKAYA K, CAN M, ELMAS Ö, BÜYÜKUYSAL M (2018). Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. , 14 - 21. 10.4274/haseki.25743
Chicago PİŞKİN Özcan,KÖKSAL Bengü Gülhan,Baş Yılmaz,KARAKAYA Kemal,CAN Murat,ELMAS Özlem,BÜYÜKUYSAL MUSTAFA ÇAĞATAY Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. (2018): 14 - 21. 10.4274/haseki.25743
MLA PİŞKİN Özcan,KÖKSAL Bengü Gülhan,Baş Yılmaz,KARAKAYA Kemal,CAN Murat,ELMAS Özlem,BÜYÜKUYSAL MUSTAFA ÇAĞATAY Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. , 2018, ss.14 - 21. 10.4274/haseki.25743
AMA PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. . 2018; 14 - 21. 10.4274/haseki.25743
Vancouver PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. . 2018; 14 - 21. 10.4274/haseki.25743
IEEE PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M "Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation." , ss.14 - 21, 2018. 10.4274/haseki.25743
ISNAD PİŞKİN, Özcan vd. "Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation". (2018), 14-21. https://doi.org/10.4274/haseki.25743
APA PİŞKİN Ö, KÖKSAL B, Baş Y, KARAKAYA K, CAN M, ELMAS Ö, BÜYÜKUYSAL M (2018). Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. Haseki Tıp Bülteni, 56(1), 14 - 21. 10.4274/haseki.25743
Chicago PİŞKİN Özcan,KÖKSAL Bengü Gülhan,Baş Yılmaz,KARAKAYA Kemal,CAN Murat,ELMAS Özlem,BÜYÜKUYSAL MUSTAFA ÇAĞATAY Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. Haseki Tıp Bülteni 56, no.1 (2018): 14 - 21. 10.4274/haseki.25743
MLA PİŞKİN Özcan,KÖKSAL Bengü Gülhan,Baş Yılmaz,KARAKAYA Kemal,CAN Murat,ELMAS Özlem,BÜYÜKUYSAL MUSTAFA ÇAĞATAY Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. Haseki Tıp Bülteni, vol.56, no.1, 2018, ss.14 - 21. 10.4274/haseki.25743
AMA PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. Haseki Tıp Bülteni. 2018; 56(1): 14 - 21. 10.4274/haseki.25743
Vancouver PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation. Haseki Tıp Bülteni. 2018; 56(1): 14 - 21. 10.4274/haseki.25743
IEEE PİŞKİN Ö,KÖKSAL B,Baş Y,KARAKAYA K,CAN M,ELMAS Ö,BÜYÜKUYSAL M "Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation." Haseki Tıp Bülteni, 56, ss.14 - 21, 2018. 10.4274/haseki.25743
ISNAD PİŞKİN, Özcan vd. "Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation". Haseki Tıp Bülteni 56/1 (2018), 14-21. https://doi.org/10.4274/haseki.25743