Yıl: 2018 Cilt: 17 Sayı: 2 Sayfa Aralığı: 40 - 48 Metin Dili: İngilizce İndeks Tarihi: 28-05-2019

EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS

Öz:
Objective: Nasal septal deviation is an obstructive pathology and can be related to inflammation. This study aimed to investigate therelationship between nasal septum deviation leading to obvious nasal obstruction and certain variables including mean platelet volume(MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). The study will alsoexamine the effect of this operation on this relationship.Materials and Methods: This is a prospective study. The study sample included 29 patient group participants that had septoplastyindications, and 31 control group participants that were healthy volunteers. Control and patient groups were compared with regard to MPV,PDW, NLR, PLR, platelet count and white blood cell (WBC) counts. The significance level was accepted as 0.05 in the relevant statisticalanalyses.Findings: The preoperative MPV and PDW levels were found to be higher in the patient group than the control group. The differencebetween them was statistically significant (p < 0.05). In the patient group, the researchers observed a decrease of 0.72 units in the MPV valueand 0.91 units in the PDW value, and an increase of 6.72 units in the platelet count at the end of the month following the operation comparedwith the relevant values in the preoperative period (p < 0.05).Result: The MPV and PDW values were high in the patients with nasal septum deviation requiring surgery. Moreover, these high MPVand PDW values were found to normalize after the operation.
Anahtar Kelime:

Konular: Kulak, Burun, Boğaz

SEPTOPLASTİNİN MEAN PLATELET VOLUME VE İNFLAMASYON MARKERLARI ÜZERİNE ETKİSİ

Öz:
Amaç: Nazal septum deviasyonu, obstruktif bir patoloji olmakla birlikte inflamasyon ile de ilişkili olabilen bir durumdur. Bu çalışmamızda bariz burun tıkanıklığına yol açan septum nazi deviasyonu olan hastalarda mean platelet volüm (MPV), platelet distrubution width (PDW), nötrofil lenfosit oranı (NLR) ve platelet lenfosit oranı (PLR) ile septum deviasyonu arasındaki ilişkiyi ve ameliyattan sonra bunun ne şekilde etkilendiğini araştırmayı amaçladık. Gereç Yöntem:< Bu prospektif çalışmada, septoplasti endikasyonu konulan 29 birey hasta grubu olarak ve 31 sağlıklı gönüllü birey ise kontrol grubu olarak çalışmaya dahil edildi. Kontrol ve hasta grubları MPV, PDW, NLR, PLR, Platelet sayısı ve White blood cell (WBC) değerleri açısından karşılaştırıldı. İstatistiksel değerlendirmelerde anlamlılık sınırı 0.05 olarak kabul edildi. Bulgular:< Septum deviasyonu olan hastaların ameliyat öncesi ile kontrol grubu karşılaştırıldığında MPV ve PDW düzeylerinin hasta grubunda istatistiksel olarak anlamlı oranda yüksek olduğu görüldü (p<0.05). Hasta grubunda ameliyat öncesi ve sonrası değerler karşılaştırıldığında ise operasyon öncesine göre operasyondan 1 ay sonra Platelet sayısında 6,72 birimlik artış tespit edilirken MPV değerinde 0,47 birimlik, PDW değerinde ise 0,91 birimlik bir azalma olduğu görüldü (p<0.05). Sonuç: Ameliyat gerektiren nazal septum deviasyonu olan hastalarda MPV ve PDW değerlerinin yüksek olduğu görüldü. Buna ek olarak MPV ve PDW değerlerindeki bu yüksekliğin ameliyattan sonra düzeldiği tespit edildi.
Anahtar Kelime:

Konular: Kulak, Burun, Boğaz
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Aziz T, Biron VL, Ansari K, Flores-Mir C. Measurement tools for the diagnosis of nasal septal deviation: a systematic review. J Otolaryngol Head Neck Surg 2014; 43:11.
  • Fidan V, and Aksakal E. Impact of septoplasty on pulmonary artery pressure in patients with markedly deviated septum. J Craniofac Surg 2011; 22:1591-1593.
  • Ozkececi G, Akci O, Bucak A, Ulu S, Yalim Z, Aycicek A, Onrat E, Avsar A. The effect of septoplasty on pulmonary artery pressure and right ventricular function in nasal septum deviation. Eur Arch Otorhinolaryngol 2016; 273:3747-3752.
  • Smitha SG, Jagannath B, and Mathew AS. Impact of Septal Correction on the Blood Pressure of Hypertensive Patients with Deviated Nasal Septum. Indian J Otolaryngol Head Neck Surg 2016; 68:46-51.
  • Unlu I, Kesici GG, Onec B,Yaman H, Guclu E. The effect of duration of nasal obstruction on mean platelet volume in patients with marked nasal septal deviation. Eur Arch Otorhinolaryngol 2016; 273:401-405.
  • Ulu S, Ulu MS, Bucak A, Kahveci OK, Yucedag F, Aycicek A. Evaluating the relationship between nasal obstruction and mean platelet volume by using acoustic rhinometry in patients with septum deviation. Rhinology 2013; 51:249-252.
  • Sagit M, Korkmaz F, Kavugudurmaz M, Somdas MA. Impact of septoplasty on mean platelet volume levels in patients with marked nasal septal deviation. J Craniofac Surg 2012; 23:974-976.
  • Sahin MS and Kizilirmak D. Changes at Mean Platelet Volume and Platelet Distribution Width Levels After Septoplasty and Its Correlation With Epworth Sleepness Scale. J Craniofac Surg 2017; 28:71-73.
  • Ulusoy B, Bozdemir K, Akyol M, Mişe HI, Kutluhan A, Korkmaz MH. Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus. J Laryngol Otol 2018;132:129-132.
  • Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32:443-460.
  • Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-tolymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014; 2014:702807.
  • Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013; 34:1400-1404.
  • Chen Y, Xiao Y, Lin Z, Xiao X, He C, Bihl JC, Zhao B, Ma X, Chen Y. The Role of Circulating Platelets Microparticles and Platelet Parameters in Acute Ischemic Stroke Patients. J Stroke Cerebrovasc Dis 2015; 24:2313-2320.
  • Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14:28-32.
  • Sevuk U, Bahadir MV, Altindag R, Baysal E, Yaylak B, Ay N, Ayaz F, Demirtas E. Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis. Ther Clin Risk Manag 2015; 11:1243-1249.
  • Liak C and Fitzpatrick M. Coagulability in obstructive sleep apnea. Can Respir J 2011; 18:338-348.
  • Buchner NJ, Quack I, Woznowski M, Stahle C, Wenzei U, Rump LC. Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration 2011; 82:409-417.
  • Derin S, Akin F, Sahan M, Altun I, Sahin C, Elicora SS. Impact of markedly nasal septal deviation on 24-hour rhythm Holter findings. Kulak Burun Bogaz Ihtis Derg 2015; 25:284-288.
APA Ulusoy B, BOZDEMİR K, Mise H, KUTLUHAN A, KORKMAZ M (2018). EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. , 40 - 48.
Chicago Ulusoy Bülent,BOZDEMİR Kazım,Mise Halil ibrahim,KUTLUHAN Ahmet,KORKMAZ Mehmet Hakan EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. (2018): 40 - 48.
MLA Ulusoy Bülent,BOZDEMİR Kazım,Mise Halil ibrahim,KUTLUHAN Ahmet,KORKMAZ Mehmet Hakan EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. , 2018, ss.40 - 48.
AMA Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. . 2018; 40 - 48.
Vancouver Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. . 2018; 40 - 48.
IEEE Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M "EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS." , ss.40 - 48, 2018.
ISNAD Ulusoy, Bülent vd. "EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS". (2018), 40-48.
APA Ulusoy B, BOZDEMİR K, Mise H, KUTLUHAN A, KORKMAZ M (2018). EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. KBB-Forum, 17(2), 40 - 48.
Chicago Ulusoy Bülent,BOZDEMİR Kazım,Mise Halil ibrahim,KUTLUHAN Ahmet,KORKMAZ Mehmet Hakan EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. KBB-Forum 17, no.2 (2018): 40 - 48.
MLA Ulusoy Bülent,BOZDEMİR Kazım,Mise Halil ibrahim,KUTLUHAN Ahmet,KORKMAZ Mehmet Hakan EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. KBB-Forum, vol.17, no.2, 2018, ss.40 - 48.
AMA Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. KBB-Forum. 2018; 17(2): 40 - 48.
Vancouver Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS. KBB-Forum. 2018; 17(2): 40 - 48.
IEEE Ulusoy B,BOZDEMİR K,Mise H,KUTLUHAN A,KORKMAZ M "EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS." KBB-Forum, 17, ss.40 - 48, 2018.
ISNAD Ulusoy, Bülent vd. "EFFECT OF SEPTOPLASTY ON THE MEAN PLATELET VOLUME AND INFLAMMATION MARKERS". KBB-Forum 17/2 (2018), 40-48.