Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?
Yıl: 2018 Cilt: 17 Sayı: 2 Sayfa Aralığı: 62 - 65 Metin Dili: İngilizce DOI: 10.17941/agd.457178 İndeks Tarihi: 13-06-2019
Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?
Öz: Background and Aims: Mean platelet volume has been studied asa simple inflammatory marker in several diseases. Some studies havereported that mean platelet volume increases in myocardial infarctionand cerebrovascular disease. Contrarily, it decreases in rheumatoidarthritis, ankylosing spondylitis, and inflammatory bowel disease. Theaim of this study was to evaluate whether mean platelet volume waschanged in celiac disease and whether it could be used to monitor agluten-free diet in patients. Materials and Methods: After excludingpatients with severe comorbidities and patients who did not complywith the gluten-free diet, a total of 50 patients with celiac disease(men/women: 9/41) and 50 healthy subjects (men/women: 10/40)were included in the study. The diagnosis of celiac disease was basedon standard serological, endoscopic, and histological criteria. The studyenrolled patients with celiac disease who recovered clinically and serologically1 year after gluten-free diet. Complete blood count analyseswere performed within 2 h after collection with the use of the Beckmancoulter analyzer. Results: Mean platelet volume levels were not significantlydifferent in the celiac disease group than that of in the controlgroup. In the celiac disease group, the mean platelet volume levels didnot change after 1 year of gluten-free diet compared with the timeof celiac disease diagnosis. On the contrary, a decrease in the plateletcount after gluten-free diet was detected. Conclusion: This studydemonstrates that mean platelet volume is not altered in patients withceliac disease, and it also showed that mean platelet volume cannotbe used as a marker for predicting dietary compliance in patients withceliac disease.
Anahtar Kelime: Konular:
Ortalama eritrosit hacim değeri çölyak hastalığı olan hastalarda inflamatuvar bir belirteç olarak kullanılabilir mi?
Öz: Giriş ve Amaç: Ortalama trombosit hacmi değişik hastalıklarda çalışılmış olan, basit ölçülebilen bir inflamatuvar belirteçtir. Miyokart enfarktüsü, inme gibi hastalıklarda ortalama trombosit hacminin arttığı, romatoid artrit ve ankilozan spondilit gibi inflamatuvar hastalıklarda ise ortalama trombosit hacminin azaldığı gösterilmiştir. Bu çalışmanın amacı çölyak hastalığı olan hastalarda ortalama trombosit hacmi seviyesinin değişip değişmediğinin saptanması ve glutensiz diyet tedavisi alan hastalarda tanı anındaki ortalama trombosit hacmi ile diyet sonrası ortalama trombosit hacim düzeyleri kıyaslanarak ortalama trombosit hacminin glutensiz diyete uyumun belirlenmesi için bir belirteç olarak kullanılıp kullanılamayacağının saptanmasıdır. Gereç ve Yöntem: Eşlik eden ciddi hastalığı olan ve glutensiz diyete yeterli şekilde uyum göstermeyen hastalar çalışmadan çıkarıldıktan sonra kalan 50 çölyak hastalığı olan hasta (erkek/kadın: 9/41) ve 50 sağlıklı gönüllü (erkek/kadın: 10/40) çalışmaya alındı ve klinik ve laboratuvar değerleri kıyaslandı. Çölyak hastalığı tanısı standart serolojik, endoskopik ve histolojik kriterlere göre konuldu. Glutensiz diyet sonrası birinci yılda klinik olarak ve serolojik olarak remisyonda olan hastaların tanı anındaki ve diyetten sonraki değerleri de karşılaştırıldı. Tam kan sayımı hastalardan kan alındıktan sonraki iki saat içinde Beckman coulter analyzer ile yapıldı. Bulgular: Çölyak hastalığı olanlar ile kontrol grubu arasında ortalama trombosit hacim düzeyi farklı saptanmadı. Çölyak grubunda da bir yıllık diyet sonrasında ortalama trombosit hacmi düzeyinde anlamlı bir değişiklik gözlenmedi, ancak diyet sonrasında tanı anına kıyasla hastaların ortalama trombosit sayısı daha düşük izlendi. Sonuç: Bu çalışma göstermiştir ki ortalama trombosit hacim düzeyinin, ne çölyak hastalığının tanısında ne de diyete uyumun bir göstergesi olarak kullanılması uygun değildir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DEMİREZER BOLAT A, Köseoğlu H, akın f, TAYFUR YÜREKLİ Ö, TAHTACI M, Başaran M, ERSOY O (2018). Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. , 62 - 65. 10.17941/agd.457178 |
| Chicago | DEMİREZER BOLAT Aylin,Köseoğlu Hüseyin,akın fatma ebru,TAYFUR YÜREKLİ ÖYKÜ,TAHTACI Mustafa,Başaran Murat,ERSOY Osman Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. (2018): 62 - 65. 10.17941/agd.457178 |
| MLA | DEMİREZER BOLAT Aylin,Köseoğlu Hüseyin,akın fatma ebru,TAYFUR YÜREKLİ ÖYKÜ,TAHTACI Mustafa,Başaran Murat,ERSOY Osman Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. , 2018, ss.62 - 65. 10.17941/agd.457178 |
| AMA | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. . 2018; 62 - 65. 10.17941/agd.457178 |
| Vancouver | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. . 2018; 62 - 65. 10.17941/agd.457178 |
| IEEE | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O "Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?." , ss.62 - 65, 2018. 10.17941/agd.457178 |
| ISNAD | DEMİREZER BOLAT, Aylin vd. "Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?". (2018), 62-65. https://doi.org/10.17941/agd.457178 |
| APA | DEMİREZER BOLAT A, Köseoğlu H, akın f, TAYFUR YÜREKLİ Ö, TAHTACI M, Başaran M, ERSOY O (2018). Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. Akademik Gastroenteroloji Dergisi, 17(2), 62 - 65. 10.17941/agd.457178 |
| Chicago | DEMİREZER BOLAT Aylin,Köseoğlu Hüseyin,akın fatma ebru,TAYFUR YÜREKLİ ÖYKÜ,TAHTACI Mustafa,Başaran Murat,ERSOY Osman Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. Akademik Gastroenteroloji Dergisi 17, no.2 (2018): 62 - 65. 10.17941/agd.457178 |
| MLA | DEMİREZER BOLAT Aylin,Köseoğlu Hüseyin,akın fatma ebru,TAYFUR YÜREKLİ ÖYKÜ,TAHTACI Mustafa,Başaran Murat,ERSOY Osman Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. Akademik Gastroenteroloji Dergisi, vol.17, no.2, 2018, ss.62 - 65. 10.17941/agd.457178 |
| AMA | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. Akademik Gastroenteroloji Dergisi. 2018; 17(2): 62 - 65. 10.17941/agd.457178 |
| Vancouver | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?. Akademik Gastroenteroloji Dergisi. 2018; 17(2): 62 - 65. 10.17941/agd.457178 |
| IEEE | DEMİREZER BOLAT A,Köseoğlu H,akın f,TAYFUR YÜREKLİ Ö,TAHTACI M,Başaran M,ERSOY O "Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?." Akademik Gastroenteroloji Dergisi, 17, ss.62 - 65, 2018. 10.17941/agd.457178 |
| ISNAD | DEMİREZER BOLAT, Aylin vd. "Can serum mean platelet volume be used as an inflammatory marker in patients with celiac disease?". Akademik Gastroenteroloji Dergisi 17/2 (2018), 62-65. https://doi.org/10.17941/agd.457178 |
