Yıl: 2018 Cilt: 48 Sayı: 2 Sayfa Aralığı: 441 - 448 Metin Dili: İngilizce DOI: 10.3906/sag-1507-193 İndeks Tarihi: 13-06-2019

Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774

Öz:
Background/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite thathas nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single andcombined applications in monolayers of the MDAH-2774 human ovarian cancer cell line.Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dyeexclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h.Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cellcultures (P < 0.05). All combination groups showed similar effects that were mainly more effective in respect to single usage of resveratroland gemcitabine in monolayer cell cultures.Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 humanovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction ofcell structure were observed.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA AYLA Ş, BILIR A, ERTÜRKOĞLU Ş, TANRIVERDİ G, SONER B, SOFUOĞLU K, GHISOLFI L, Oktem G (2018). Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. , 441 - 448. 10.3906/sag-1507-193
Chicago AYLA ŞULE,BILIR AYHAN,ERTÜRKOĞLU Şenol,TANRIVERDİ GAMZE,SONER B. Cem,SOFUOĞLU Kenan,GHISOLFI Laura,Oktem Gulperi Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. (2018): 441 - 448. 10.3906/sag-1507-193
MLA AYLA ŞULE,BILIR AYHAN,ERTÜRKOĞLU Şenol,TANRIVERDİ GAMZE,SONER B. Cem,SOFUOĞLU Kenan,GHISOLFI Laura,Oktem Gulperi Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. , 2018, ss.441 - 448. 10.3906/sag-1507-193
AMA AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. . 2018; 441 - 448. 10.3906/sag-1507-193
Vancouver AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. . 2018; 441 - 448. 10.3906/sag-1507-193
IEEE AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G "Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774." , ss.441 - 448, 2018. 10.3906/sag-1507-193
ISNAD AYLA, ŞULE vd. "Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774". (2018), 441-448. https://doi.org/10.3906/sag-1507-193
APA AYLA Ş, BILIR A, ERTÜRKOĞLU Ş, TANRIVERDİ G, SONER B, SOFUOĞLU K, GHISOLFI L, Oktem G (2018). Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences, 48(2), 441 - 448. 10.3906/sag-1507-193
Chicago AYLA ŞULE,BILIR AYHAN,ERTÜRKOĞLU Şenol,TANRIVERDİ GAMZE,SONER B. Cem,SOFUOĞLU Kenan,GHISOLFI Laura,Oktem Gulperi Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences 48, no.2 (2018): 441 - 448. 10.3906/sag-1507-193
MLA AYLA ŞULE,BILIR AYHAN,ERTÜRKOĞLU Şenol,TANRIVERDİ GAMZE,SONER B. Cem,SOFUOĞLU Kenan,GHISOLFI Laura,Oktem Gulperi Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences, vol.48, no.2, 2018, ss.441 - 448. 10.3906/sag-1507-193
AMA AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences. 2018; 48(2): 441 - 448. 10.3906/sag-1507-193
Vancouver AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences. 2018; 48(2): 441 - 448. 10.3906/sag-1507-193
IEEE AYLA Ş,BILIR A,ERTÜRKOĞLU Ş,TANRIVERDİ G,SONER B,SOFUOĞLU K,GHISOLFI L,Oktem G "Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774." Turkish Journal of Medical Sciences, 48, ss.441 - 448, 2018. 10.3906/sag-1507-193
ISNAD AYLA, ŞULE vd. "Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774". Turkish Journal of Medical Sciences 48/2 (2018), 441-448. https://doi.org/10.3906/sag-1507-193