Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury
Yıl: 2018 Cilt: 48 Sayı: 1 Sayfa Aralığı: 187 - 190 Metin Dili: İngilizce DOI: 10.3906/sag-1706-160 İndeks Tarihi: 18-06-2019
Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury
Öz: Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been welldocumented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteineon erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion.Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized controlgroup (group ‘control’, n = 6), an ischemia/reperfusion group without erdosteine (group ‘ischemia/reperfusion’, n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg–1, intraperitoneally (group ‘ischemia/reperfusion – erdosteine’, n = 6). Packs oferythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion – erdosteine groups revealed similar results (P = 0.051). The values ofthe ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion – erdosteine groups (P <0.0001 and P = 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/reperfusion compared to the control and ischemia/reperfusion – erdosteine groups (P < 0.05).Conclusion: We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbancein blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversingundesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies withlarger volumes.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Özer A, DEMİRTAŞ H, ÇOMU F, ERER D, Kılıç Y, MARDİN B, Arslan M, Küçük A, OKTAR G (2018). Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. , 187 - 190. 10.3906/sag-1706-160 |
| Chicago | Özer Abdullah,DEMİRTAŞ Hüseyin,ÇOMU Faruk Metin,ERER Dilek,Kılıç Yiğit,MARDİN Barış,Arslan Mustafa,Küçük Ayşegül,OKTAR G. Levent Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. (2018): 187 - 190. 10.3906/sag-1706-160 |
| MLA | Özer Abdullah,DEMİRTAŞ Hüseyin,ÇOMU Faruk Metin,ERER Dilek,Kılıç Yiğit,MARDİN Barış,Arslan Mustafa,Küçük Ayşegül,OKTAR G. Levent Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. , 2018, ss.187 - 190. 10.3906/sag-1706-160 |
| AMA | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. . 2018; 187 - 190. 10.3906/sag-1706-160 |
| Vancouver | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. . 2018; 187 - 190. 10.3906/sag-1706-160 |
| IEEE | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G "Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury." , ss.187 - 190, 2018. 10.3906/sag-1706-160 |
| ISNAD | Özer, Abdullah vd. "Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury". (2018), 187-190. https://doi.org/10.3906/sag-1706-160 |
| APA | Özer A, DEMİRTAŞ H, ÇOMU F, ERER D, Kılıç Y, MARDİN B, Arslan M, Küçük A, OKTAR G (2018). Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences, 48(1), 187 - 190. 10.3906/sag-1706-160 |
| Chicago | Özer Abdullah,DEMİRTAŞ Hüseyin,ÇOMU Faruk Metin,ERER Dilek,Kılıç Yiğit,MARDİN Barış,Arslan Mustafa,Küçük Ayşegül,OKTAR G. Levent Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences 48, no.1 (2018): 187 - 190. 10.3906/sag-1706-160 |
| MLA | Özer Abdullah,DEMİRTAŞ Hüseyin,ÇOMU Faruk Metin,ERER Dilek,Kılıç Yiğit,MARDİN Barış,Arslan Mustafa,Küçük Ayşegül,OKTAR G. Levent Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences, vol.48, no.1, 2018, ss.187 - 190. 10.3906/sag-1706-160 |
| AMA | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences. 2018; 48(1): 187 - 190. 10.3906/sag-1706-160 |
| Vancouver | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences. 2018; 48(1): 187 - 190. 10.3906/sag-1706-160 |
| IEEE | Özer A,DEMİRTAŞ H,ÇOMU F,ERER D,Kılıç Y,MARDİN B,Arslan M,Küçük A,OKTAR G "Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury." Turkish Journal of Medical Sciences, 48, ss.187 - 190, 2018. 10.3906/sag-1706-160 |
| ISNAD | Özer, Abdullah vd. "Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury". Turkish Journal of Medical Sciences 48/1 (2018), 187-190. https://doi.org/10.3906/sag-1706-160 |
