Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonarydysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed tohyperoxia and inflammation.Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O2) +lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O2). Pups in thehyperoxia + LPS + ginger group were administered oral ginger at a dose of 1000 mg/kg daily during the study period. Histopathologic,immunochemical (SMA and lamellar body), and biochemical evaluations including total antioxidant status (TAS), total oxidantstatus (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β),interleukin-6 (IL-6), and caspase-3 activities were performed.Results: Better weight gain and survival rates were shown in the hyperoxia + LPS + ginger group (P < 0.05). In the histopathologicand immunochemical evaluation, severity of lung damage was significantly reduced in the hyperoxia + LPS + ginger group, as wellas decreased apoptosis (ELISA for caspase-3) (P < 0.05). Tissue TAS levels were significantly protected, and TOS, MDA, and MPOlevels were significantly lower in the hyperoxia + LPS + ginger group (P < 0.05). Tissue TNF-α, IL-1β, and IL-6 concentrations weresignificantly decreased in the ginger-treated group (P < 0.05).Conclusion: Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation.Therefore, ginger may be an alternative option for the treatment of BPD.